{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T22:37:52Z","timestamp":1780699072295,"version":"3.54.1"},"reference-count":23,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BM"],"published-print":{"date-parts":[[2012,9,1]]},"abstract":"<jats:p>Members of the intestinal microbiota play an important role in the development of T-cells. Little is known about responses of intestinal T-cell subsets of chickens to commensal bacteria. Therefore, we set out to characterise cytokine responses in T-cells after exposure to lactobacilli. Caecal tonsil mononuclear cells were isolated and co-cultured with <jats:italic>Lactobacillus acidophilus<\/jats:italic>, <jats:italic>Lactobacillus reuteri<\/jats:italic> and <jats:italic>Lactobacillus salivarius<\/jats:italic> for 12 hours. Subsequently the CD4+ and CD8+ cells were fractionated by flow cytometry and the expression of pro- and anti-inflammatory cytokines as well as Toll-like receptor 21 (TLR21) was determined. The results demonstrated that chicken CD4+ and CD8+ T-cells express TLR21 and that the various isolates of lactobacilli differentially induces the expression of interleukin 10, interferon-gamma and transforming growth factor beta. Our results demonstrate that different <jats:italic>Lactobacillus<\/jats:italic> species have the capacity to regulate intestinal T-cell responses and that these responses may be important to intestinal homeostasis.<\/jats:p>","DOI":"10.3920\/bm2012.0014","type":"journal-article","created":{"date-parts":[[2012,9,12]],"date-time":"2012-09-12T03:34:17Z","timestamp":1347420857000},"page":"205-210","source":"Crossref","is-referenced-by-count":27,"title":["Differential cytokine expression in T-cell subsets of chicken caecal tonsils co-cultured with three species of Lactobacillus"],"prefix":"10.1163","volume":"3","author":[{"given":"J.T.","family":"Brisbin","sequence":"first","affiliation":[{"name":"Department of Pathobiology, Ontario Veterinary College, University of Guelph, 419 Gordon Street, Building 89, Guelph, Ontario N1G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Parvizi","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, Ontario Veterinary College, University of Guelph, 419 Gordon Street, Building 89, Guelph, Ontario N1G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Sharif","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, Ontario Veterinary College, University of Guelph, 419 Gordon Street, Building 89, Guelph, Ontario N1G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2007.09.003"},{"key":"atypb2","first-page":"1337","volume":"17","journal-title":"Clinical and Vaccine Imunology"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.05100-11"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600867"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e3283476d3e"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.08.023"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.4.1809"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6941.2006.00193.x"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.08.009"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.7.2879"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-010-1017-1"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2010.04091.x"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.05.007"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2006.00694.x"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.1.559"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200535244"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00788-10"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.2174\/187152806778256043"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2008.0062"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2009.06.009"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2004.02.005"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1051\/vetres:2006036"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1002\/ar.10062"}],"container-title":["Beneficial Microbes"],"original-title":[],"link":[{"URL":"https:\/\/brill.com\/view\/journals\/bm\/3\/3\/article-p205_205.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/brill.com\/view\/journals\/bm\/3\/3\/article-p205_205.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/brill.com\/view\/journals\/bm\/3\/3\/article-p205_205.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T08:28:52Z","timestamp":1709108932000},"score":1,"resource":{"primary":{"URL":"https:\/\/brill.com\/view\/journals\/bm\/3\/3\/article-p205_205.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,1]]},"references-count":23,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3920\/bm2012.0014","relation":{},"ISSN":["1876-2883","1876-2891"],"issn-type":[{"value":"1876-2883","type":"print"},{"value":"1876-2891","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,1]]}}}