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Plasma tryptophan and kynurenine levels reflected high indoleamine dioxygenase activity, which was supported by significant temporal induction of the encoding gene in all gut tissues. However, the majority of genes associated with neuronal development and function were reduced. Colonic substance P elevation in response to conventionalisation was higher only after 30-days. These results support a functional microbiota-neurohumoral relationship during conventionalisation and suggest a delayed neuronal response that is elicited only after the microbiota accommodating homeostasis has been accomplished.<\/jats:p>","DOI":"10.3920\/bm2012.0042","type":"journal-article","created":{"date-parts":[[2012,12,13]],"date-time":"2012-12-13T02:04:58Z","timestamp":1355364298000},"page":"251-259","source":"Crossref","is-referenced-by-count":65,"title":["The microbiota and the gut-brain axis: insights from the temporal and spatial mucosal alterations during colonisation of the germfree mouse intestine"],"prefix":"10.1163","volume":"3","author":[{"given":"S.","family":"El Aidy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Kunze","sequence":"additional","affiliation":[{"name":"Brain-Body Institute, Departments of Psychiatry and Pathology, McMaster University, 54 Charlton Avenue East, Hamilton, ON L8N 4A6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bienenstock","sequence":"additional","affiliation":[{"name":"Brain-Body Institute, Departments of Psychiatry and Pathology, McMaster University, 54 Charlton Avenue East, Hamilton, ON L8N 4A6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kleerebezem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.226779"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-1591(02)00078-8"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.01.075"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2010.01664.x"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2297"},{"key":"atypb6","first-page":"164","volume":"3","journal-title":"Journal of Psychiatric Research"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2012.32"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2004-5-10-r80"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1010529108"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1007\/BF02087542"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2006.07.013"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.2174\/1567202054368326"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2010.01620.x"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5032-08.2009"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2000.7542"},{"key":"atypb16","first-page":"G1473","volume":"276","journal-title":"American Journal of Physiology"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2010.12.005"},{"key":"atypb18","first-page":"134","volume":"411","journal-title":"Methods in Enzymology"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.2001.00265.x"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.063388"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2009.05.001"},{"key":"atypb22","unstructured":"Handbook of molecular microbial ecology, Vol II: Metagenomics in different habitats177190"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.066100"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1096\/fj.09-153841"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0812874106"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1021\/pr901188e"}],"container-title":["Beneficial Microbes"],"original-title":[],"link":[{"URL":"https:\/\/brill.com\/view\/journals\/bm\/3\/4\/article-p251_251.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/brill.com\/view\/journals\/bm\/3\/4\/article-p251_251.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/brill.com\/view\/journals\/bm\/3\/4\/article-p251_251.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T08:27:16Z","timestamp":1709108836000},"score":1,"resource":{"primary":{"URL":"https:\/\/brill.com\/view\/journals\/bm\/3\/4\/article-p251_251.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,1]]},"references-count":26,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.3920\/bm2012.0042","relation":{},"ISSN":["1876-2883","1876-2891"],"issn-type":[{"value":"1876-2883","type":"print"},{"value":"1876-2891","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,1]]}}}