{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T08:30:49Z","timestamp":1744187449556,"version":"3.38.0"},"reference-count":37,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BM"],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:p>We investigated the potential probiotic properties of indigenous lactic acid bacteria (LAB) isolated from Serbian homemade cheese. Seventeen LAB strains were isolated and characterised using standard protocols. One of the strains showed several probiotic properties: survival at low pH and in bile salts solution, antimicrobial activity, susceptibility to antibiotics and adhesion to hexodecane. DNA analysis identified the isolate as <jats:italic>Lactobacillus casei,<\/jats:italic> hereafter named <jats:italic>L. casei<\/jats:italic> 5s. The lipid lowering effect of <jats:italic>L. casei<\/jats:italic> 5s was evaluated <jats:italic>in vivo<\/jats:italic> using a hyperlipidemic rat model. Orally administered <jats:italic>L. casei<\/jats:italic> 5s significantly decreased the elevated total serum cholesterol and triglycerides, and attenuated macro vesicular steatosis in the liver. Moreover, <jats:italic>L. casei<\/jats:italic> 5s improved the intestinal microbial balance in favour of lactobacilli, while decreasing the number of <jats:italic>Escherichia coli<\/jats:italic> cells. The bacteria were re-isolated and identified from the surface of the intestinal mucosa and from the faecal samples of treated animals, indicating adhesiveness and colonisation ability. The results of an acute oral toxicity study in mice and the absence of translocation to other organs demonstrated the safety of the strain. In conclusion, <jats:italic>L. casei<\/jats:italic> 5s demonstrated promising probiotic potential and might be a good candidate for more detailed investigations.<\/jats:p>","DOI":"10.3920\/bm2014.0018","type":"journal-article","created":{"date-parts":[[2014,6,3]],"date-time":"2014-06-03T01:20:54Z","timestamp":1401758454000},"page":"119-128","source":"Crossref","is-referenced-by-count":4,"title":["Characterisation and preliminary lipid-lowering evaluation of Lactobacillus isolated from a traditional Serbian dairy product"],"prefix":"10.1163","volume":"6","author":[{"given":"G.","family":"Zavi\u0161i\u0107","sequence":"first","affiliation":[{"name":"Galenika a.d., R\u00d7D Institute, Batajni\u00e8ki drum bb, 11080 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Risti\u0107","sequence":"additional","affiliation":[{"name":"Galenika a.d., R\u00d7D Institute, Batajni\u00e8ki drum bb, 11080 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Petri\u00e8evi\u0107","sequence":"additional","affiliation":[{"name":"Galenika a.d., R\u00d7D Institute, Batajni\u00e8ki drum bb, 11080 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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