{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:58:07Z","timestamp":1789966687021,"version":"4.0.1"},"reference-count":34,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BM"],"published-print":{"date-parts":[[2016,11,30]]},"abstract":"<jats:p>The aim was to evaluate the effect of <jats:italic>Saccharomyces cerevisiae<\/jats:italic> RC016 on immune parameters and gut microbiota in healthy mice. Animals received <jats:italic>S. cerevisiae<\/jats:italic> RC016 for 10 days. Microbial translocation to liver and changes in some bacterial populations in caecum were determined. Immune stimulation was assessed at gut level (measure of immunoglobulin A (IgA)<jats:sup>+<\/jats:sup> cells and luminal cytokine profile) and by evaluating the activity of peritoneal macrophages. Oral administration of <jats:italic>S. cerevisiae<\/jats:italic> RC016 did not induce microbial translocation to liver. Mice that received yeast increased the number of IgA<jats:sup>+<\/jats:sup> cells in their intestines, the phagocytic activity of peritoneal macrophages and decreased tumour necrosis factor alpha (TNF-\u03b1) levels in the small intestine with increases of interleukin-10\/TNF-\u03b1ratio. Administration of <jats:italic>S. cerevisiae<\/jats:italic> RC016 caused the decline of a logarithmic unit for <jats:italic>Enterobacteriaceae<\/jats:italic> counts compared to the control. The immune and gut microbiota modulation observed demonstrates that <jats:italic>S. cerevisiae<\/jats:italic> RC016 is a promising candidate for the formulation of feed additives to improve animal productivity. The beneficial <jats:italic>in vivo<\/jats:italic> effects observed for the potential probiotic <jats:italic>S. cerevisiae<\/jats:italic> RC016 with previously reported mycotoxin-binding properties, demonstrated that this strain could be suitable to be included in a novel product to improve animal productivity, with both probiotic and mycotoxin-binding properties. However, studies in the specific host will be necessary to confirm this potential.<\/jats:p>","DOI":"10.3920\/bm2015.0071","type":"journal-article","created":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T16:50:14Z","timestamp":1480351814000},"page":"659-668","source":"Crossref","is-referenced-by-count":16,"title":["Gut-borne Saccharomyces cerevisiae, a promising candidate for the formulation of feed additives, modulates immune system and gut microbiota"],"prefix":"10.1163","volume":"7","author":[{"given":"G.","family":"Garc\u00eda","sequence":"first","affiliation":[{"name":"Departamento de Microbiolog\u00eda e Inmunolog\u00eda, Universidad Nacional de R\u00edo Cuarto, Ruta 36 km. 601, 5800 R\u00edo Cuarto, C\u00f3rdoba, Argentina."},{"name":"Fellow of Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Dogi","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda e Inmunolog\u00eda, Universidad Nacional de R\u00edo Cuarto, Ruta 36 km. 601, 5800 R\u00edo Cuarto, C\u00f3rdoba, Argentina."},{"name":"Member of Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"de Moreno de LeBlanc","sequence":"additional","affiliation":[{"name":"Member of Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Argentina."},{"name":"Centro de Referencia para Lactobacilos (CERELA-CONICET), Chacabuco 145, T4000ILC San Miguel de Tucum\u00e1n, Tucum\u00e1n, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Greco","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda e Inmunolog\u00eda, Universidad Nacional de R\u00edo Cuarto, Ruta 36 km. 601, 5800 R\u00edo Cuarto, C\u00f3rdoba, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Cavaglieri","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda e Inmunolog\u00eda, Universidad Nacional de R\u00edo Cuarto, Ruta 36 km. 601, 5800 R\u00edo Cuarto, C\u00f3rdoba, Argentina."},{"name":"Member of Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.12-0368"},{"key":"atypb2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3920\/WMJ2008.x007","volume":"1","journal-title":"World Mycotoxin Journal"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1080\/19440049.2012.698655"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1159\/000342079"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2007-0457"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/j.anifeedsci.2007.04.019"},{"key":"atypb7","first-page":"274","volume":"6","journal-title":"Microbe"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03442.x"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2010.01.020"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2007.07.002"},{"key":"atypb11","unstructured":"Importance of IL-10 modulation by probiotic microorganisms in gastrointestinal inflammatory diseases"},{"key":"atypb12","first-page":"37","volume":"10","journal-title":"Current Issues in Molecular Biology"},{"key":"atypb13","first-page":"1705","volume":"28","journal-title":"Food Additives and Contaminants Part A"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2007.11.014"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(99)01448-6"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00406-06"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1111\/jam.12552"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.2217\/17460913.3.3.315"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2004.tb18021.x"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1126\/science.1155725"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.27224"},{"key":"atypb23","first-page":"282","volume":"44","journal-title":"Gut"},{"key":"atypb24","first-page":"141","volume":"13","journal-title":"International Journal of Immunopathology and Pharmacology"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.3.641"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1186\/2049-1891-4-1"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90006-3"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1017\/S1751731113000062"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2001.tb10858.x"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939483"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1177\/10.3.250"},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.22358\/jafs\/70012\/2001"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1007\/s11250-012-0257-3"},{"key":"atypb34","doi-asserted-by":"publisher","DOI":"10.4161\/gmic.1.3.11712"},{"key":"atypb35","doi-asserted-by":"publisher","DOI":"10.1080\/09540100120075844"}],"container-title":["Beneficial Microbes"],"original-title":[],"link":[{"URL":"https:\/\/brill.com\/view\/journals\/bm\/7\/5\/article-p659_7.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/brill.com\/downloadpdf\/journals\/bm\/7\/5\/article-p659_7.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/brill.com\/downloadpdf\/journals\/bm\/7\/5\/article-p659_7.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T08:43:10Z","timestamp":1713343390000},"score":1,"resource":{"primary":{"URL":"https:\/\/brill.com\/view\/journals\/bm\/7\/5\/article-p659_7.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,30]]},"references-count":34,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3920\/bm2015.0071","relation":{},"ISSN":["1876-2883","1876-2891"],"issn-type":[{"value":"1876-2883","type":"print"},{"value":"1876-2891","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,30]]}}}