{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T14:23:58Z","timestamp":1785335038362,"version":"3.55.0"},"reference-count":39,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2017,2,7]],"date-time":"2017-02-07T00:00:00Z","timestamp":1486425600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BM"],"published-print":{"date-parts":[[2017,2,7]]},"abstract":"<jats:p>Commensal skin microbiota plays an important role in both influencing the immune response of the skin and acting as a barrier against colonisation of potentially pathogenic microorganisms and overgrowth of opportunistic pathogens. <jats:italic>Staphylococcus epidermidis<\/jats:italic> is a key constituent of the normal microbiota on human skin. It balances the inflammatory response after skin injury and produces antimicrobial molecules that selectively inhibit skin pathogens. Here we describe <jats:italic>Lactobacillus brevis<\/jats:italic> DSM17250 that was identified among hundreds of <jats:italic>Lactobacillus<\/jats:italic> strains to exhibit an anti-inflammatory effect in human keratinocytes <jats:italic>in vitro<\/jats:italic> and specific stimulatory impact on the growth of <jats:italic>S. epidermidis<\/jats:italic>. The aqueous cell-free extract of <jats:italic>L. brevis<\/jats:italic> DSM17250 was used in an ointment formulation and tested in a randomized placebo-controlled double blinded human pilot study. Healthy volunteers with diagnosed dry skin were treated for four weeks. The study data shows that <jats:italic>L. brevis<\/jats:italic> DSM17250 extract induces re-colonisation of the skin by protective commensal microorganisms as judged from selective bacterial cultivation of surface-associated skin microorganism of the lower leg. Furthermore, the 4 week administration of the <jats:italic>L. brevis<\/jats:italic> DSM17250 extract significantly improved the transepidermal water loss value (TEWL), reduced the xerosis cutis symptoms and stinging. The data shows that daily application of <jats:italic>L. brevis<\/jats:italic> DSM17250 extract in a topical product significantly improves the microbial skin microbiota by promoting the growth of species which possess beneficial regulatory and protective properties such as <jats:italic>S. epidermidis<\/jats:italic>. Restoring the natural skin microbiota leads to significantly improved skin barrier function (as transepidermal water loss) and decrease of xeroderma (xerosis cutis) symptoms (as measured by dry skin area and severity index, DASI). We propose that improving and stabilizing the natural skin microbiota by specifically stimulating the growth of <jats:italic>S. epidermidis<\/jats:italic> is an important and novel concept to manage skin diseases associated with microbiota dysbiosis.<\/jats:p>","DOI":"10.3920\/bm2016.0073","type":"journal-article","created":{"date-parts":[[2016,11,8]],"date-time":"2016-11-08T13:39:09Z","timestamp":1478612349000},"page":"121-132","source":"Crossref","is-referenced-by-count":28,"title":["Novel bioactive from Lactobacillus brevis DSM17250 to stimulate the growth of Staphylococcus epidermidis: a pilot study"],"prefix":"10.1163","volume":"8","author":[{"given":"C.","family":"Holz","sequence":"first","affiliation":[{"name":"Organobalance GmbH, Gustav-Meyer-Allee 25, 13355 Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Benning","sequence":"additional","affiliation":[{"name":"Organobalance GmbH, Gustav-Meyer-Allee 25, 13355 Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Schaudt","sequence":"additional","affiliation":[{"name":"Analyse & Realize GmbH, Waldseeweg 6, 13467 Berlin, Germany."},{"name":"PRA health Sciences, Gottlieb-Daimler-Stra\u03b2e 10, 68165 Mannheim, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Heilmann","sequence":"additional","affiliation":[{"name":"Organobalance GmbH, Gustav-Meyer-Allee 25, 13355 Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Schultchen","sequence":"additional","affiliation":[{"name":"Organobalance GmbH, Gustav-Meyer-Allee 25, 13355 Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Goelling","sequence":"additional","affiliation":[{"name":"Organobalance GmbH, Gustav-Meyer-Allee 25, 13355 Berlin, 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