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Diabetic rats were then fed<jats:italic>Lactobacillus rhamnosus<\/jats:italic>NCDC 17 and<jats:italic>L. rhamnosus<\/jats:italic>GG with HFD for six weeks.<jats:italic>L. rhamnosus<\/jats:italic>NCDC 17 improved oral glucose tolerance test, biochemical parameters (fasting blood glucose, plasma insulin, glycosylated haemoglobin, free fatty acids, triglycerides, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol), oxidative stress (thiobarbituric acid reactive substance and activities of catalase, superoxide dismutase and glutathione peroxidase in blood and liver), bifidobacteria and lactobacilli in cecum, expression of glucagon like peptide-1 producing genes in cecum, and adiponection in epididymal fat, while decreased propionate proportions (%) in caecum, and expression of tumour necrosis factor-\u03b1 and interlukin-6 in epididymal fat of diabetic rats as compared to diabetes control group. These findings offered a base for the use of<jats:italic>L. rhamnosus<\/jats:italic>NCDC 17 for the improvement and early treatment of type 2 diabetes.<\/jats:p>","DOI":"10.3920\/bm2016.0090","type":"journal-article","created":{"date-parts":[[2016,12,23]],"date-time":"2016-12-23T13:06:00Z","timestamp":1482498360000},"page":"243-256","source":"Crossref","is-referenced-by-count":103,"title":["Lactobacillus rhamnosus NCDC17 ameliorates type-2 diabetes by improving gut function, oxidative stress and inflammation in high-fat-diet fed and streptozotocintreated rats"],"prefix":"10.1163","volume":"8","author":[{"given":"S.","family":"Singh","sequence":"first","affiliation":[{"name":"Animal Biochemistry Division, National Dairy Research Institute, Karnal 132001, Haryana, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.K.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Animal Biochemistry Division, National Dairy Research Institute, Karnal 132001, 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