{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:13:21Z","timestamp":1790709201879,"version":"4.1.0"},"reference-count":28,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BM"],"published-print":{"date-parts":[[2017,8,24]]},"abstract":"<jats:p>Ingestion of milks fermented by <jats:italic>Lactobacillus<\/jats:italic> strains showing probiotic properties is an important tool to maintain gastrointestinal health. In this study, <jats:italic>Lactobacillus rhamnosus<\/jats:italic> D1 and <jats:italic>Lactobacillus plantarum<\/jats:italic> B7, isolated from Brazilian artisanal cheese, were used as starters for the functional fermented milks to assess their probiotic properties in a gnotobiotic animal model. Male germ-free Swiss mice received a single oral dose of milk fermented by each sample, and were challenged with <jats:italic>Salmonella<\/jats:italic> Typhimurium five days afterwards. Milk fermented by both <jats:italic>Lactobacillus<\/jats:italic> strains maintained counts above 10<jats:sup>8<\/jats:sup> cfu\/ml during cold storage. <jats:italic>Lactobacillus<\/jats:italic> strains colonised the gut of the germ-free-mice, maintaining their antagonistic effect. This colonisation led to a protective effect against <jats:italic>Salmonella<\/jats:italic> challenge, as demonstrated by reduced pathogen translocation and histological lesions, when compared to control group, especially for <jats:italic>Lactobacillus rhamnosus<\/jats:italic> D1. Additionally, mRNA expression of inflammatory (interferon gamma, interleukin (IL)-6, tumour necrosis factor alpha) and anti-inflammatory (transforming growth factor \u03b21) cytokines was augmented in animals previously colonised and then challenged, when compared to other experimental groups. <jats:italic>Lactobacillus plantarum<\/jats:italic> B7 colonisation also promoted higher expression of IL-17, showing a proper maturation of colonised germ-free-mice immune system. IL-5 was stimulated by both strains\u2019 colonisation and not by <jats:italic>S<\/jats:italic>. Typhimurium challenge.<\/jats:p>","DOI":"10.3920\/bm2016.0163","type":"journal-article","created":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T07:58:17Z","timestamp":1502265497000},"page":"579-588","source":"Crossref","is-referenced-by-count":22,"title":["Milk fermented by Lactobacillus species from Brazilian artisanal cheese protect germ-free-mice against Salmonella Typhimurium infection"],"prefix":"10.1163","volume":"8","author":[{"given":"L.B.","family":"Acurcio","sequence":"first","affiliation":[{"name":"Department of Microbiology, Biological Science Institute (ICB \u2013 Instituto de Ci\u00eancias Biol\u00f3gicas), Federal University of Minas Gerais (UFMG \u2013 Universidade Federal de Minas Gerais), Av. Pres. Ant\u00f4nio Carlos, 6627, Pampulha, 31270-901 Belo Horizonte, MG, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.H.C.","family":"Sandes","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Biological Science Institute (ICB \u2013 Instituto de Ci\u00eancias Biol\u00f3gicas), Federal University of Minas Gerais (UFMG \u2013 Universidade Federal de Minas Gerais), Av. Pres. Ant\u00f4nio Carlos, 6627, Pampulha, 31270-901 Belo Horizonte, MG, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.W.","family":"Bastos","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Biological Science Institute (ICB \u2013 Instituto de Ci\u00eancias Biol\u00f3gicas), Federal University of Minas Gerais (UFMG \u2013 Universidade Federal de Minas Gerais), Av. Pres. Ant\u00f4nio Carlos, 6627, Pampulha, 31270-901 Belo Horizonte, MG, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.M.","family":"Sant\u2019anna","sequence":"additional","affiliation":[{"name":"Department of Meat and Dairy Products Technology and Inspection (DTIPOA), Veterinary School (EV \u2013 Escola de Veterin\u00e1ria), Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.H.S.P.","family":"Pedroso","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Biological Science Institute (ICB \u2013 Instituto de Ci\u00eancias Biol\u00f3gicas), Federal University of Minas Gerais (UFMG \u2013 Universidade Federal de Minas Gerais), Av. Pres. 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Ant\u00f4nio Carlos, 6627, Pampulha, 31270-901 Belo Horizonte, MG, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.D.","family":"Cassali","sequence":"additional","affiliation":[{"name":"Department of Pathology, ICB, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.R.","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Meat and Dairy Products Technology and Inspection (DTIPOA), Veterinary School (EV \u2013 Escola de Veterin\u00e1ria), Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.R.","family":"Nicoli","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Biological Science Institute (ICB \u2013 Instituto de Ci\u00eancias Biol\u00f3gicas), Federal University of Minas Gerais (UFMG \u2013 Universidade Federal de Minas Gerais), Av. 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