{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T11:01:21Z","timestamp":1792407681740,"version":"4.4.0"},"reference-count":47,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BM"],"published-print":{"date-parts":[[2017,5,30]]},"abstract":"<jats:p>The antidiabetic effect of <jats:italic>Lactobacillus<\/jats:italic> is increasingly recognized worldwide. In this research, the hypoglycemic activity of <jats:italic>Lactobacillus casei<\/jats:italic> CCFM419 was investigated in mice with high-fat and low-dose streptozotocin induced type 2 diabetes. Oral <jats:italic>L. casei<\/jats:italic> CCFM419 administration favourably regulated blood glucose balance, increased glucose tolerance and protected islets in the diabetic mice, accompanied by an improvement in lipid metabolism. The homeostasis model of insulin resistance, insulin level and insulin tolerance test and mRNA expression of PI3K\/Akt signalling pathway indexes revealed that <jats:italic>L. casei<\/jats:italic> CCFM419 had a positive effect on insulin resistance. Furthermore, treatment with <jats:italic>L. casei<\/jats:italic> CCFM419 recovered the level of short-chain fatty acids and increased the abundance of butyrate-producing bacteria, such as <jats:italic>Allobaculum<\/jats:italic> and <jats:italic>Bacteriodes<\/jats:italic>. These results demonstrated that <jats:italic>L. casei<\/jats:italic> CCFM419 had the potential ability to ameliorate insulin resistance and hyperglycaemic in type 2 diabetic mice through underlying PI3K\/Akt signalling pathway and short-chain fatty acids\/gut microbiota pathways.<\/jats:p>","DOI":"10.3920\/bm2016.0167","type":"journal-article","created":{"date-parts":[[2017,5,15]],"date-time":"2017-05-15T13:17:17Z","timestamp":1494854237000},"page":"421-432","source":"Crossref","is-referenced-by-count":126,"title":["Effects of Lactobacillus casei CCFM419 on insulin resistance and gut microbiota in type 2 diabetic mice"],"prefix":"10.1163","volume":"8","author":[{"given":"X.","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China P.R."},{"name":"Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, 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