{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T22:31:24Z","timestamp":1774391484425,"version":"3.50.1"},"reference-count":36,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BM"],"published-print":{"date-parts":[[2018,1,29]]},"abstract":"<jats:p>To better understand the role of gut microbiota in the anxiety, we isolated bifidobacteria and lactobacilli from the human faecal microbiota, investigated their inhibitory effects on the expression of interleukin (IL)-6 and tumour necrosis factor (TNF)-\u03b1 in lipopolysaccharide-stimulated macrophages, and examined the anxiolytic-like effect of <jats:italic>Bifidobacterium adolescentis<\/jats:italic> IM38 in mice treated with or without immobilisation stress using the elevated plus maze (EPM) task. Oral administration of IM38 at a dose of 1\u00d710<jats:sup>9<\/jats:sup> cfu\/mouse showed a significant anxiolytic-like effect both in mice exposed to immobilisation stress and in control mice using the EPM test (<jats:italic>P<\/jats:italic>&lt;0.05). Moreover, IM38 treatment significantly increased the amount of time spent on open arms and open arm entries. The anxiolytic-like effect of IM38 was comparable to that of buspirone (1 mg\/kg). Moreover, this anxiolytic-like effect was blocked by treatment with flumazenil (3 mg\/kg, i.p.), a benzodiazepine receptor antagonist, but was not affected by treatment with bicuculine or WAY-100635. IM38 treatment also reduced the blood levels of corticosterone and IL-6 in mice with or without immobilisation stress, whereas this effect was abolished by treatment with flumazenil. IM38 treatment also reduced the blood TNF-\u03b1 level in mice subjected to immobilisation stress but not in normal control mice. Treatment with flumazenil also significantly increased TNF-\u03b1 and IL-6 levels in immobilisation stress-free mice treated with IM38. These findings suggest that IM38 may attenuate anxiety through modulation of the benzodiazepine site on the GABA<jats:sub>A<\/jats:sub> receptor and modulate stress-related cytokine expression.<\/jats:p>","DOI":"10.3920\/bm2016.0226","type":"journal-article","created":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T08:55:42Z","timestamp":1507020942000},"page":"123-132","source":"Crossref","is-referenced-by-count":34,"title":["Anxiolytic-like effect of Bifidobacterium adolescentis IM38 in mice with or without immobilisation stress"],"prefix":"10.1163","volume":"9","author":[{"given":"H.M.","family":"Jang","sequence":"first","affiliation":[{"name":"Neurobiota Research Center, Department of Life and Nanopharmaceutical Sciences, and Department of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of 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