{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:28:15Z","timestamp":1790256495232,"version":"4.1.0"},"reference-count":59,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BM"],"published-print":{"date-parts":[[2018,2,27]]},"abstract":"\n Plantaricin EF (PlnEF) is a class IIb bacteriocin produced by\n Lactobacillus plantarum<\/jats:italic>\n . We compared\n L. plantarum<\/jats:italic>\n NCIMB8826 and LM0419, a\n plnEFI<\/jats:italic>\n deletion mutant of that strain lacking\n plnEF<\/jats:italic>\n and the gene for the cognate immunity protein\n plnI<\/jats:italic>\n , in a 2,4,6-trinitrobenzenesulfonic acid (TNBS) induced mouse model of acute inflammatory bowel disease. Mice fed either\n L. plantarum<\/jats:italic>\n NCIMB8826 or LM0419 were not protected against TNBS according to either disease activity or histology (Ameho) scores. Mice consuming NCIMB8826 exhibited intermediate (non-significant) levels of colonic tumour necrosis factor alpha (TNF-\u03b1) and interleukin-6 (IL-6) that ranged between the TNBS-treated animals and healthy controls. By comparison, TNF-\u03b1 and IL-6 quantities were elevated in mice given\n L. plantarum<\/jats:italic>\n LM0419 and equivalent to mice given TNBS alone. Both strains survived digestive tract transit in equal numbers and did not result in global changes to the bacterial composition in the intestine according to 16S rRNA gene sequencing either prior to or after TNBS administration. Examination of intestinal taxa showed that mice consuming wild-type\n L. plantarum<\/jats:italic>\n , but not LM0419 contained lower proportions of\n Mucispirillum<\/jats:italic>\n (\n Deferribacteres<\/jats:italic>\n phylum) in the faeces prior to TNBS administration and\n Parabacteroides<\/jats:italic>\n (\n Bacteroidetes<\/jats:italic>\n phylum) in the caecum after disease induction.\n Parabacteroides<\/jats:italic>\n also positively correlated with disease activity and histology scores. These findings suggest a role for PlnEFI production by\n L. plantarum<\/jats:italic>\n in benefiting digestive tract health.\n <\/jats:p>","DOI":"10.3920\/bm2017.0096","type":"journal-article","created":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T03:54:08Z","timestamp":1508903648000},"page":"333-344","source":"Crossref","is-referenced-by-count":51,"title":["Bacteriocin biosynthesis contributes to the anti-inflammatory capacities of probiotic Lactobacillus plantarum"],"prefix":"10.1163","volume":"9","author":[{"given":"X.","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Food Science and Technology, University of California, One Shields Avenue, Davis, CA 95616, USA."},{"name":"Department of Plant Pathology, University of California, One Shields Avenue, Davis CA 95616-8751, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Heeney","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology, 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