{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T19:56:15Z","timestamp":1787860575224,"version":"build-2784847793"},"reference-count":56,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T00:00:00Z","timestamp":1529020800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BM"],"published-print":{"date-parts":[[2018,6,15]]},"abstract":"<jats:p>Some food-derived opioid peptides have been reported to cause diseases, such as gastrointestinal inflammation, celiac disease, and mental disorders.<jats:italic>Bifidobacterium<\/jats:italic>is a major member of the dominant human gut microbiota, particularly in the gut of infants. In this study, we evaluated the potential of<jats:italic>Bifidobacterium<\/jats:italic>in the degradation of food-derived opioid peptides. All strains tested showed some level of dipeptidyl peptidase activity, which is thought to be involved in the degradation of food-derived opioid peptides. However, this activity was higher in bifidobacterial strains that are commonly found in the intestines of human infants, such as<jats:italic>Bifidobacterium longum<\/jats:italic>subsp.<jats:italic>longum<\/jats:italic>,<jats:italic>B. longum<\/jats:italic>subsp.<jats:italic>infantis<\/jats:italic>,<jats:italic>Bifidobacterium breve<\/jats:italic>and<jats:italic>Bifidobacterium bifidum<\/jats:italic>, than in those of other species, such as<jats:italic>Bifidobacterium animalis<\/jats:italic>and<jats:italic>Bifidobacterium pseudolongum<\/jats:italic>. In addition, some<jats:italic>B. longum<\/jats:italic>subsp.<jats:italic>infantis<\/jats:italic>and<jats:italic>B. bifidum<\/jats:italic>strains showed degradative activity in food-derived opioid peptides such as human and bovine milk-derived casomorphin-7 and wheat gluten-derived gliadorphin-7. A further screening of<jats:italic>B. bifidum<\/jats:italic>strains revealed some bifidobacterial strains that could degrade all three peptides. Our results revealed the potential of<jats:italic>Bifidobacterium<\/jats:italic>species in the degradation of food-derived opioid peptides, particularly for species commonly found in the intestine of infants. Selected strains of<jats:italic>B. longum<\/jats:italic>subsp.<jats:italic>infantis<\/jats:italic>and<jats:italic>B. bifidum<\/jats:italic>with high degradative capabilities can be used as probiotic microorganisms to eliminate food-derived opioid peptides and contribute to host health.<\/jats:p>","DOI":"10.3920\/bm2017.0165","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T09:45:24Z","timestamp":1523353524000},"page":"675-682","source":"Crossref","is-referenced-by-count":17,"title":["Degradation of food-derived opioid peptides by bifidobacteria"],"prefix":"10.1163","volume":"9","author":[{"given":"T.","family":"Sakurai","sequence":"first","affiliation":[{"name":"Morinaga Milk Industry Co., Ltd., Frontier Research Department, Next Generation Science Institute, 1-83, 5-Chome, Higashihara, Zama-City, Kanagawa-Pref. 252-8583, 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