{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T14:00:28Z","timestamp":1760709628952,"version":"3.38.0"},"reference-count":39,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BM"],"published-print":{"date-parts":[[2018,9,14]]},"abstract":"<jats:p>\n<jats:italic>Helicobacter pylori<\/jats:italic> infection is associated with important gastric pathologies. An aggressive proinflammatory immune response is generated in the gastric tissue infected with <jats:italic>H. pylori<\/jats:italic>, resulting in gastritis and a series of morphological changes that increase the susceptibility to cancer development. Probiotics could present an alternative solution to prevent or decrease <jats:italic>H. pylori<\/jats:italic> infection. Among them, the use of immunomodulatory lactic acid bacteria represents a promising option to reduce the severity of chronic inflammatory-mediated tissue damage and to improve protective immunity against <jats:italic>H. pylori<\/jats:italic>. We previously isolated <jats:italic>Lactobacillus fermentum<\/jats:italic> UCO-979C from human gastric tissue and demonstrated its capacity to reduce adhesion of <jats:italic>H. pylori<\/jats:italic> to human gastric epithelial cells (AGS cells). In this work, the ability of <jats:italic>L. fermentum<\/jats:italic> UCO-979C to modulate immune response in AGS cells and PMA phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 (human monocytic leukaemia) macrophages in response to <jats:italic>H. pylori<\/jats:italic> infection was evaluated. We demonstrated that the UCO-979C strain is able to differentially modulate the cytokine response of gastric epithelial cells and macrophages after <jats:italic>H. pylori<\/jats:italic> infection. Of note, <jats:italic>L. fermentum<\/jats:italic> UCO-979C was able to significantly reduce the production of inflammatory cytokines and chemokines in AGS and THP-1 cells as well as increase the levels of immunoregulatory cytokines, indicating a remarkable anti-inflammatory effect. These findings strongly support the probiotic potential of <jats:italic>L. fermentum<\/jats:italic> UCO-979C and provide evidence of its beneficial effects against the inflammatory damage induced by <jats:italic>H. pylori<\/jats:italic> infection. Although our findings should be proven in appropriate experiments <jats:italic>in vivo<\/jats:italic>, in both <jats:italic>H. pylori<\/jats:italic> infection animal models and human trials, the results of the present work provide a scientific rationale for the use of <jats:italic>L. fermentum<\/jats:italic> UCO-979C to prevent or reduce <jats:italic>H. pylori<\/jats:italic>-induced gastric inflammation in humans.<\/jats:p>","DOI":"10.3920\/bm2018.0019","type":"journal-article","created":{"date-parts":[[2018,5,25]],"date-time":"2018-05-25T09:52:14Z","timestamp":1527241934000},"page":"829-842","source":"Crossref","is-referenced-by-count":21,"title":["Lactobacillus fermentum UCO-979C beneficially modulates the innate immune response triggered by Helicobacter pylori infection in vitro"],"prefix":"10.1163","volume":"9","author":[{"given":"V.","family":"Garcia-Castillo","sequence":"first","affiliation":[{"name":"Laboratory of Bacterial Pathogenicity, Faculty of Biological Sciences, University of Concepcion, Chacabuco s\/n, Concepcion, Bio Bio 4030000, Chile."},{"name":"Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), Tucuman 4000, Argentina."},{"name":"Food and Feed Immunology Group, Graduate School of Agricultural Science, Tohoku University, Sendai 84-0051, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Zelaya","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), Tucuman 4000, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ilabaca","sequence":"additional","affiliation":[{"name":"Laboratory of Bacterial Pathogenicity, Faculty of Biological Sciences, University of Concepcion, Chacabuco s\/n, Concepcion, Bio Bio 4030000, Chile."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Espinoza-Monje","sequence":"additional","affiliation":[{"name":"Laboratory of Bacterial Pathogenicity, Faculty of Biological Sciences, University of Concepcion, Chacabuco s\/n, Concepcion, Bio Bio 4030000, Chile."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Komatsu","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), Tucuman 4000, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Albarrac\u00edn","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), Tucuman 4000, Argentina."},{"name":"Food and Feed Immunology Group, Graduate School of Agricultural Science, Tohoku University, Sendai 84-0051, Japan."},{"name":"Laboratory of Computing Science, Faculty of Exact Sciences and Technology, Tucuman University, Av. 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