{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:55:54Z","timestamp":1790402154057,"version":"4.1.0"},"reference-count":41,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BM"],"published-print":{"date-parts":[[2019,3,13]]},"abstract":"<jats:p>The effect of oral administration of spray-dried microcapsules of feruloyl esterase (FE) producing <jats:italic>Lactobacillus fermentum<\/jats:italic> CRL1446 (Lf) and <jats:italic>Lactobacillus johnsonii<\/jats:italic> CRL1231 (Lj) on high fat diet-induced obese mice was investigated to evaluate whether these strains could be used as a biotherapeutic for obesity. Swiss albino mice were divided into a normal diet fed group receiving empty microcapsules (control), a high fat diet plus empty microcapsules (HFD group), HFD plus microcapsules with Lf (HFD-Lf group) and HDF plus microcapsules with Lj (HFD-Lj group). Microcapsules containing Lf or Lj at a dose of ~10<jats:sup>7<\/jats:sup> cells\/day\/mouse were given orally for 7 weeks. Body weight gain, adiposity index, plasma leptin, lipid profiles, glycaemia, insulinemia, oral glucose tolerance, intestinal FE, glutathione peroxidase and glutathione reductase (GR) activities were determined. Administration of lactobacilli (HFD-Lf and HFD-Lj groups) improved metabolic parameters (triglyceride, total cholesterol, low-density lipoprotein cholesterol levels) and cardiovascular risk indicators (37-46% decrease of atherogenic index), and reduced body weight gain (29-38%), adiposity index (42-62%), plasma leptin levels, liver weight and fat deposition in liver. Intestinal FE activities significantly increased in HFD-Lf (62%) and HFD-Lj group (48%), thus improving hepatic GR activity (42% increment) compared to HFD group. Moreover, <jats:italic>L. johnsonii<\/jats:italic> increased HDL-cholesterol and <jats:italic>L. fermentum<\/jats:italic> reduced blood glucose to levels similar to the control. These FE-producing lactobacilli have the potential to improve biomarkers involved in obesity by increasing intestinal FE activity.<\/jats:p>","DOI":"10.3920\/bm2018.0025","type":"journal-article","created":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T11:38:56Z","timestamp":1544441936000},"page":"189-198","source":"Crossref","is-referenced-by-count":9,"title":["Microencapsulated feruloyl esterase-producing lactobacilli ameliorate lipid profile and glycaemia in high fat diet-induced obese mice"],"prefix":"10.1163","volume":"10","author":[{"given":"M.","family":"Russo","sequence":"first","affiliation":[{"name":"Centro de Referencia para Lactobacilos (CERELA)-CONICET, Chacabuco 145, T4000ILC, San Miguel de Tucum\u00e1n, Tucum\u00e1n, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Marquez","sequence":"additional","affiliation":[{"name":"Centro de Referencia para Lactobacilos (CERELA)-CONICET, Chacabuco 145, T4000ILC, San Miguel de Tucum\u00e1n, Tucum\u00e1n, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.C.","family":"Abeij\u00f3n-Mukdsi","sequence":"additional","affiliation":[{"name":"Centro de Referencia para Lactobacilos (CERELA)-CONICET, Chacabuco 145, T4000ILC, San Miguel de Tucum\u00e1n, Tucum\u00e1n, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Santacruz","sequence":"additional","affiliation":[{"name":"Departamento de Biotecnolog\u00eda, Instituto Tecnol\u00f3gico y de Estudios Superiores de Monterrey, Av. 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