{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T07:06:59Z","timestamp":1790320019900,"version":"4.1.0"},"reference-count":29,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BM"],"published-print":{"date-parts":[[2019,2,8]]},"abstract":"Poultry is an important high-quality food and protein source for humans. However, chicken is considered a primary source of foodborne diseases, especially Salmonella<\/jats:italic> Enteritidis infection. Reducing Salmonella<\/jats:italic> contamination in live poultry will thus lower the risk to consumers. Our previous studies reported that Lactobacillus reuteri<\/jats:italic> KUB-AC5 can produce a substance with antimicrobial activity against pathogenic bacteria, especially Salmonella. In vivo<\/jats:italic> testing revealed that this strain greatly influenced the ileal microbiota by improving chicken gastrointestinal health and inhibiting certain pathogenic bacteria. However, its activity against Salmonella<\/jats:italic> in chicken is unknown. This study investigated the effects of the probiotic L. reuteri<\/jats:italic> KUB-AC5 at various concentrations against Salmonella<\/jats:italic> and the microbiota status in the gastrointestinal tract of broiler chickens. Four treatments groups were used: negative-control group (no Salmonella<\/jats:italic> challenge), positive-control group (Salmonella<\/jats:italic> challenge), and 5 or 7 log cfu probiotic supplementation to Salmonella<\/jats:italic>-challenged chickens. The resultant microbial diversities at the growing and finisher stages were not significantly different among the groups (P<\/jats:italic>>0.05). However, a high dosage of KUB-AC5 maintained similar microbial diversity in Salmonella<\/jats:italic>-challenged chickens as observed in the non-challenged group in the early stage. The exposure Salmonella<\/jats:italic> can affect the microbial diversity that consequently contributes to the disease progression in chicken. Low and high dosages of KUB-AC5 eliminated S.<\/jats:italic> Enteritidis from the ileum and caecum at 14, 21 and 35 days of age. A high-dose of KUB-AC5 also enhanced Lactobacillaceae<\/jats:italic> levels in the growing stage in both the ileum and caecum and suppressed Enterobacteriaceae<\/jats:italic> levels in the finisher stage on day 35, whereas these effects were not observed in the low dose of KUB-AC5 or control groups. These results support the potential value of high-dose L. reuteri<\/jats:italic> KUB-AC5 supplementation for three days after hatching in preventing Salmonella<\/jats:italic> infection in chickens.<\/jats:p>","DOI":"10.3920\/bm2018.0034","type":"journal-article","created":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T10:55:18Z","timestamp":1541674518000},"page":"43-54","source":"Crossref","is-referenced-by-count":49,"title":["Protective effect of Lactobacillus reuteri KUB-AC5 against Salmonella Enteritidis challenge in chickens"],"prefix":"10.1163","volume":"10","author":[{"given":"M.","family":"Nakphaichit","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Faculty of Agro-Industry, Kasetsart University, Chatuchak, Bangkok 10900, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Sobanbua","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Faculty of Agro-Industry, Kasetsart University, Chatuchak, Bangkok 10900, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Siemuang","sequence":"additional","affiliation":[{"name":"Research and development center, Betagro group, 136 Moo 9, Klong Nueng, Klong Luang Pathumthani 12120, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Vongsangnak","sequence":"additional","affiliation":[{"name":"Department of Zoology, Faculty of Science, Kasetsart University, Chatuchak, Bangkok 10900, Thailand."},{"name":"Computational Biomodelling Laboratory for Agricultural Science and Technology (CBLAST), Faculty of Science, Kasetsart University, Bangkok 10900, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Laboratory of Microbial Technology, Division of Applied Molecular Microbiology and Biomass Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Higashi-ku, Fukuoka 812-8581, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Nitisinprasert","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Faculty of Agro-Industry, Kasetsart University, Chatuchak, Bangkok 10900, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anifeedsci.2016.05.004"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.70.6.3575-3581.2004"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.4652"},{"key":"atypb4","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1128\/AEM.68.1.114-123.2002","volume":"68","journal-title":"Applied and Environmental 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