{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T14:58:36Z","timestamp":1788101916079,"version":"build-2803163510"},"reference-count":66,"publisher":"Walter de Gruyter GmbH","issue":"5","license":[{"start":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T00:00:00Z","timestamp":1559001600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BM"],"published-print":{"date-parts":[[2019,5,28]]},"abstract":"<jats:p>We aimed at assessing the evidence for an effect on vaginal dysbiosis by oral administration of a mixture of <jats:italic>Lactobacillus<\/jats:italic> strains isolated from vaginal microbiota. For this purpose, we systematically reviewed the literature for randomised clinical trials (RCTs) in which the effect of oral administration of a mixture of four <jats:italic>Lactobacillus<\/jats:italic> strains (<jats:italic>Lactobacillus crispatus<\/jats:italic> LbV 88 (DSM 22566), <jats:italic>Lactobacillus gasseri<\/jats:italic> LbV 150N (DSM 22583), <jats:italic>Lactobacillus jensenii<\/jats:italic> LbV 116 (DSM 22567) and <jats:italic>Lactobacillus rhamnosus<\/jats:italic> LbV96 (DSM 22560)) on vaginal dysbiosis was examined based on Nugent score. Four RCTs were identified: a double-blind (DB)-RCT in 60 male-to-female transsexual women with neovagina; an open label RCT in 60 pregnant women with herpes virus infection; a DB-RCT in 36 women with bacterial vaginosis; a DB-RCT in 22 postmenopausal breast cancer patients receiving chemotherapy. Only in the three DB-RCTs Nugent score was assessed. The meta-analysis of these trials showed a significant reduction of Nugent score by probiotics compared to placebo in the fixed (standardised mean differences (SMD) -0.561; confidence interval (CI) -0.935 to -0.186; <jats:italic>P<\/jats:italic>=0.004 and random effect models (SMD -0.561; CI -0.935 to -0.186; <jats:italic>P<\/jats:italic>=0.004). The odds ratio (OR) of the cases presenting with improved Nugent score after probiotics compared to placebo treatment showed a significant effect in the fixed (OR=3.936; CI 1.702 to 9.100; <jats:italic>P<\/jats:italic>=0.001) and random effect model (OR=3.902; CI 1.681 to 9.059; <jats:italic>P<\/jats:italic>=0.001) Cochran\u2019s Q and I<jats:sup>2<\/jats:sup> statistics showed no heterogeneity. This meta-analysis indicates that the oral intake of the pertinent <jats:italic>Lactobacillus<\/jats:italic> strains improves the microbial pattern in vaginal dysbiosis.<\/jats:p>","DOI":"10.3920\/bm2018.0129","type":"journal-article","created":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T13:14:13Z","timestamp":1556025253000},"page":"483-496","source":"Crossref","is-referenced-by-count":20,"title":["Impact of oral administration of four Lactobacillus strains on Nugent score \u2013 systematic review and meta-analysis"],"prefix":"10.1163","volume":"10","author":[{"given":"M.","family":"de Vrese","sequence":"first","affiliation":[{"name":"Max Rubner-Institut, Federal Research Institute of Nutrition and Food, Department of Microbiology and Biotechnology; Hermann-Weigmann-Stra\u03b2e 1, 24117 Kiel, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Laue","sequence":"additional","affiliation":[{"name":"Clinical Research Center, Schauenburgerstra\u03b2e 116, 24118 Kiel, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Papazova","sequence":"additional","affiliation":[{"name":"Clinical Research Center, Schauenburgerstra\u03b2e 116, 24118 Kiel, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Petricevic","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Fetomaternal Medicine, Medical University of Vienna, W\u00e4hringer G\u00fcrtel 18-20, 1090 Vienna, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Schrezenmeir","sequence":"additional","affiliation":[{"name":"Clinical Research Center, Schauenburgerstra\u03b2e 116, 24118 Kiel, Germany."},{"name":"University Medicine, Langenbeckstra\u03b2e 1, 55131 Mainz, 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