{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:28:04Z","timestamp":1792682884969,"version":"4.5.0"},"reference-count":46,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BM"],"published-print":{"date-parts":[[2019,4,19]]},"abstract":"<jats:p>\n                    Probiotics have been reported to exert beneficial effects along the gut-brain axis. This randomised, double-blind and placebo-controlled human study aimed to evaluate such properties of\n                    <jats:italic>Lactobacillus plantarum<\/jats:italic>\n                    DR7 and its accompanying mechanisms in stressed adults. One hundred and eleven (n=111; DR7 n=56, placebo n=55) stressed adults were recruited based on moderate stress levels using the PSS-10 questionnaire. The consumption of DR7 (1\u00d710\n                    <jats:sup>9<\/jats:sup>\n                    cfu\/day) for 12 weeks reduced symptoms of stress (\n                    <jats:italic>P<\/jats:italic>\n                    =0.024), anxiety (\n                    <jats:italic>P<\/jats:italic>\n                    =0.001), and total psychological scores (\n                    <jats:italic>P<\/jats:italic>\n                    =0.022) as early as 8 weeks among stressed adults compared to the placebo group as assessed by the DASS-42 questionnaire. Plasma cortisol level was reduced among DR7 subjects as compared to the placebo, accompanied by reduced plasma pro-inflammatory cytokines, such as interferon-\u03b3 and transforming growth factor-\u03b1 and increased plasma anti-inflammatory cytokines, such as interleukin 10 (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05). DR7 better improved cognitive and memory functions in normal adults (&gt;30 years old), such as basic attention, emotional cognition, and associate learning (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05), as compared to the placebo and young adults (&lt;30 years old). The administration of DR7 enhanced the serotonin pathway, as observed by lowered expressions of plasma dopamine \u03b2-hydroxylase (DBH), tyrosine hydroxylase (TH), indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase accompanied by increased expressions of tryptophan hydroxylase-2 and 5-hydroxytryptamine receptor-6, while stabilising the dopamine pathway as observed via stabilised expressions of TH and DBH over 12 weeks as compared to the placebo (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05). Our results indicated that DR7 fulfil the requirement of a probiotic strain as per recommendation of FAO\/WHO and could be applicable as a natural strategy to improve psychological functions, cognitive health and memory in stressed adults.\n                  <\/jats:p>","DOI":"10.3920\/bm2018.0135","type":"journal-article","created":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T08:56:02Z","timestamp":1552899362000},"page":"355-374","source":"Crossref","is-referenced-by-count":200,"title":["Lactobacillus plantarum DR7 alleviates stress and anxiety in adults: a randomised, double-blind, placebo-controlled study"],"prefix":"10.1163","volume":"10","author":[{"given":"H.X.","family":"Chong","sequence":"first","affiliation":[{"name":"School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.A. A.","family":"Yusoff","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Malaysia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.-Y.","family":"Hor","sequence":"additional","affiliation":[{"name":"School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.-C.","family":"Lew","sequence":"additional","affiliation":[{"name":"School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.H.","family":"Jaafar","sequence":"additional","affiliation":[{"name":"School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.-B.","family":"Choi","sequence":"additional","affiliation":[{"name":"School of Data Sciences, Perdana University, 43400 Serdang, Malaysia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.S.B.","family":"Yusoff","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Malaysia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Wahid","sequence":"additional","affiliation":[{"name":"Community Health Center, Universiti Sains Malaysia, 11800 Penang, Malaysia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.F.I.L.","family":"Abdullah","sequence":"additional","affiliation":[{"name":"Advanced Medical and Dental Institute, Universiti Sains Malaysia, 13200 Bertam, Malaysia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Zakaria","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Malaysia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.-L.","family":"Ong","sequence":"additional","affiliation":[{"name":"Clinical Nutrition Intl (M) Sdn Bhd, 43200 Selangor, Malaysia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.-H.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Yeungnam University, Joyeong-dong, Gyeongsan, Gyeongsangbuk-do, 712-749, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.-T.","family":"Liong","sequence":"additional","affiliation":[{"name":"School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, 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