{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:23:43Z","timestamp":1791897823537,"version":"4.3.4"},"reference-count":20,"publisher":"Walter de Gruyter GmbH","issue":"5","license":[{"start":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T00:00:00Z","timestamp":1559001600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BM"],"published-print":{"date-parts":[[2019,5,28]]},"abstract":"<jats:p>\n                    Microbial metabolism in the gut may alter human bile acid metabolism in a way that beneficially affects lipid homeostasis and therefore cardiovascular disease risk. Deconjugation of bile acids by microbes is thought to be key to this mechanism but has yet to be characterised in blood and stool while observing lipid markers. The aim of this study was to determine the effect of 3 different probiotic strains on plasma and stool bile acids in the context of lipid and glucose metabolism. In this 18-week, randomised, double-blind crossover study, healthy adults (53\u00b18 years) with a high waist circumference underwent a 1-week pre-baseline period and were then randomised to receive 1 capsule\/day of\n                    <jats:italic>Bacillus subtilis<\/jats:italic>\n                    R0179 (2.5\u00d710\n                    <jats:sup>9<\/jats:sup>\n                    cfu\/capsule; n=39),\n                    <jats:italic>Lactobacillus plantarum<\/jats:italic>\n                    HA-119 (5\u00d710\n                    <jats:sup>9<\/jats:sup>\n                    cfu\/capsule; n=38),\n                    <jats:italic>Bifidobacterium animalis<\/jats:italic>\n                    subsp.\n                    <jats:italic>lactis<\/jats:italic>\n                    B94 (5\u00d710\n                    <jats:sup>9<\/jats:sup>\n                    cfu\/capsule; n=37) or placebo for 6 weeks. Following a 3-week washout and second pre-baseline week, participants were crossed to the other intervention for 6 weeks followed by a 1-week post-intervention period. Blood and stool samples were collected at the beginning and end of each intervention to measure bile acids, serum lipid profiles, and glucose and insulin levels. Data from the placebo intervention were combined for all participants for analyses. In obese participants, the difference (final-baseline) in the sum of deconjugated plasma bile acids was greater with consumption of\n                    <jats:italic>B. subtilis<\/jats:italic>\n                    (691\u00b1378 nmol\/l,\n                    <jats:italic>P<\/jats:italic>\n                    =0.01) and\n                    <jats:italic>B. lactis<\/jats:italic>\n                    (380\u00b1165 nmol\/l,\n                    <jats:italic>P<\/jats:italic>\n                    =0.04) than with placebo (98\u00b1176 nmol\/l, n=57). No significant differences were observed for any probiotics for stool bile acids, serum lipids, blood glucose or insulin. These data suggest that\n                    <jats:italic>B. subtilis<\/jats:italic>\n                    and\n                    <jats:italic>B. lactis<\/jats:italic>\n                    had no effect on glucose metabolism or serum cholesterol but increased deconjugated plasma bile acids in obese individuals. Additional studies should be conducted to confirm these findings and explore potential mechanisms. This trial was registered at clinicaltrials.gov as NCT01879098.\n                  <\/jats:p>","DOI":"10.3920\/bm2018.0151","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T11:01:19Z","timestamp":1557918079000},"page":"497-510","source":"Crossref","is-referenced-by-count":44,"title":["Three probiotic strains exert different effects on plasma bile acid profiles in healthy obese adults: randomised, double-blind placebo-controlled crossover study"],"prefix":"10.1163","volume":"10","author":[{"given":"T.","family":"Culpepper","sequence":"first","affiliation":[{"name":"Food Science and Human Nutrition Department, University of Florida, 572 Newell Drive, Gainesville, FL 32611, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.C.","family":"Rowe","sequence":"additional","affiliation":[{"name":"Food Science and Human Nutrition Department, University of Florida, 572 Newell Drive, Gainesville, FL 32611, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.T.","family":"Rusch","sequence":"additional","affiliation":[{"name":"Food Science and Human Nutrition Department, University of Florida, 572 Newell Drive, Gainesville, FL 32611, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"Burns","sequence":"additional","affiliation":[{"name":"Food Science and Human Nutrition Department, University of Florida, 572 Newell Drive, Gainesville, FL 32611, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.P.","family":"Federico","sequence":"additional","affiliation":[{"name":"Food Science and Human Nutrition Department, University of Florida, 572 Newell Drive, Gainesville, FL 32611, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.-A.","family":"Girard","sequence":"additional","affiliation":[{"name":"Lallemand Health Solutions Inc., 6100 Royalmount, Montr\u00e9al, QC H4P 2R2, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.A.","family":"Tompkins","sequence":"additional","affiliation":[{"name":"Lallemand Health Solutions Inc., 6100 Royalmount, Montr\u00e9al, QC H4P 2R2, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Nieves","sequence":"additional","affiliation":[{"name":"Food Science and Human Nutrition Department, University of Florida, 572 Newell Drive, Gainesville, FL 32611, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.C.","family":"Dennis-Wall","sequence":"additional","affiliation":[{"name":"Food Science and Human Nutrition Department, University of Florida, 572 Newell Drive, Gainesville, FL 32611, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.C.","family":"Christman","sequence":"additional","affiliation":[{"name":"Department of Statistics, University of Florida, 102 Griffin-Floyd Hall, Gainesville, FL 32611, USA."},{"name":"Department of Biology, University of Florida, Bartram Hall, 876 Newell Drive, Gainesville, FL 32611, USA."},{"name":"MCC Statistical Consulting LLC, 2219 NW 23rd Ter, Gainesville, FL 32605, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Langkamp-Henken","sequence":"additional","affiliation":[{"name":"Food Science and Human Nutrition Department, University of Florida, 572 Newell Drive, Gainesville, FL 32611, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.307409"},{"key":"atypb2","first-page":"53","volume":"943","journal-title":"Journal of Chromatography 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