{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:30:31Z","timestamp":1790836231403,"version":"4.1.0"},"reference-count":3,"publisher":"Walter de Gruyter GmbH","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BM"],"published-print":{"date-parts":[[2019,10,14]]},"abstract":"<jats:p>We aimed to evaluate colonisation patterns of <jats:italic>Akkermansia muciniphila<\/jats:italic> in a Greek adult population and to investigate model-adjusted associations of <jats:italic>A. muciniphila<\/jats:italic> with host adiposity and cardiometabolic markers. Participants (n=125) underwent anthropometric, dietary, physical activity and lifestyle evaluation. Blood sampling for determination of blood lipid indices, glucose metabolism, adiponectin, lipoprotein-associated phospholipase A<jats:sub>2<\/jats:sub> (Lp-PLA<jats:sub>2<\/jats:sub>), inflammation and oxidative stress parameters was also performed. Stool <jats:italic>A. muciniphila<\/jats:italic> presence and levels were determined by quantitative PCR and subjects were grouped based on bimodal distribution of levels (Low vs High). <jats:italic>A. muciniphila<\/jats:italic> was detected in 88.6% of participants. Overweight\/obese (OW\/OB) subjects were more prone in low bimodal levels of <jats:italic>A. muciniphila<\/jats:italic> compared to normal-weight (NW) individuals (58.75 vs 27.59%, <jats:italic>P<\/jats:italic>=0.004), with a 4-time greater likelihood after multi-adjusted logistic regression analysis (<jats:italic>P<\/jats:italic>=0.016). Levels of <jats:italic>A. muciniphila<\/jats:italic> were negatively associated with total cholesterol\/high-density lipoprotein cholesterol (TC\/HDL-C) ratio (log<jats:sub>10<\/jats:sub>:-0.009\u00b10.004, <jats:italic>P<\/jats:italic>=0.033), whereas detection of this bacterium was negatively associated with both TC\/HDL-C ratio (log<jats:sub>10<\/jats:sub>: -0.049\u00b10.023, <jats:italic>P<\/jats:italic>=0.036) and low-density lipoprotein cholesterol\/HDL-C ratio (-0.407\u00b10.176, <jats:italic>P<\/jats:italic>=0.023). Furthermore, low bimodal levels of <jats:italic>A. muciniphila<\/jats:italic> were positively associated with fasting blood glucose (log<jats:sub>10<\/jats:sub>: 0.018\u00b10.009, <jats:italic>P<\/jats:italic>=0.037). In terms of inflammation markers, levels of <jats:italic>A. muciniphila<\/jats:italic> were positively associated with soluble cluster of differentiation-14 (sCD14) (log<jats:sub>10<\/jats:sub>: 0.012\u00b10.004, <jats:italic>P<\/jats:italic>=0.003) and faecal detection of this bacterium had a positive association with anti-inflammatory interleukin 10 levels (log<jats:sub>10<\/jats:sub>: 0.325\u00b10.131, <jats:italic>P<\/jats:italic>=0.015). In addition, <jats:italic>A. muciniphila<\/jats:italic> levels were positively associated with total adiponectin (log<jats:sub>10<\/jats:sub>: 0.046\u00b10.015, <jats:italic>P<\/jats:italic>=0.002), whereas low bimodal levels of <jats:italic>A. muciniphila<\/jats:italic> had an inverse relationship with this blood marker (log<jats:sub>10<\/jats:sub>: -0.131\u00b10.053, <jats:italic>P<\/jats:italic>=0.016). In conclusion, we confirmed the previously reported association of <jats:italic>A. muciniphila<\/jats:italic> with metabolic health for the first time in a Greek urban population; furthermore, we shed some light to novel atherosclerotic risk markers with rather unexplored connections with <jats:italic>A. muciniphila<\/jats:italic> colonisation patterns in human subjects.<\/jats:p>","DOI":"10.3920\/bm2019.0033","type":"journal-article","created":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T06:57:44Z","timestamp":1569826664000},"page":"741-750","source":"Crossref","is-referenced-by-count":15,"title":["Mining possible associations of faecal A. muciniphila colonisation patterns with host adiposity and cardiometabolic markers in an adult population"],"prefix":"10.1163","volume":"10","author":[{"given":"E.K.","family":"Mitsou","sequence":"first","affiliation":[{"name":"Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 70. El. Venizelou str., 17671 Kallithea, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Detopoulou","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 70. El. Venizelou str., 17671 Kallithea, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kakali","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 70. El. Venizelou str., 17671 Kallithea, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Fragopoulou","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 70. El. Venizelou str., 17671 Kallithea, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Nomikos","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 70. El. Venizelou str., 17671 Kallithea, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Antonopoulou","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 70. El. Venizelou str., 17671 Kallithea, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.B.","family":"Panagiotakos","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 70. El. Venizelou str., 17671 Kallithea, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kyriacou","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 70. El. Venizelou str., 17671 Kallithea, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"atypb13","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","volume":"18","journal-title":"Clinical Chemistry"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"atypb23","first-page":"757","volume":"5","journal-title":"Vascular Health and Risk Management"}],"container-title":["Beneficial Microbes"],"original-title":[],"link":[{"URL":"https:\/\/brill.com\/view\/journals\/bm\/10\/7\/article-p741_4.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/brill.com\/downloadpdf\/journals\/bm\/10\/7\/article-p741_4.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/brill.com\/downloadpdf\/journals\/bm\/10\/7\/article-p741_4.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T09:28:30Z","timestamp":1713259710000},"score":1,"resource":{"primary":{"URL":"https:\/\/brill.com\/view\/journals\/bm\/10\/7\/article-p741_4.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,14]]},"references-count":3,"journal-issue":{"issue":"7"},"URL":"https:\/\/doi.org\/10.3920\/bm2019.0033","relation":{},"ISSN":["1876-2883","1876-2891"],"issn-type":[{"value":"1876-2883","type":"print"},{"value":"1876-2891","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,14]]}}}