{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T19:04:01Z","timestamp":1790535841315,"version":"4.1.0"},"reference-count":3,"publisher":"Walter de Gruyter GmbH","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BM"],"published-print":{"date-parts":[[2019,12,9]]},"abstract":"<jats:p>Type 1 diabetes mellitus (T1DM) is a disorder resulting from chronic autoimmune destruction of insulin-producing pancreatic \u03b2-cells, lack of insulin production and hyperglycaemia. The aim of this study was to evaluate the hypothesis that streptozotocin-diabetic mice treated with <jats:italic>Saccharomyces boulardii<\/jats:italic> THT 500101 strain present improvement of glucose and triglycerides metabolism, reduction of liver inflammation concomitant with a beneficial impact in the gut microbiota profile. C57BL\/6 male mice were randomly assigned into three groups: Control, Diabetes, Diabetes+Probiotic, and were euthanised 8 weeks after probiotic chronic administration. Mice submitted to treatment presented reduced glycemia in comparison with the diabetic group, which was correlated with an increase in C-peptide level and in hepatic glycogen content. Fat metabolism was significantly altered in streptozotocin-induced diabetic group, and <jats:italic>S. boulardii<\/jats:italic> treatment regulated it, leading to a decrease in serum triglycerides secretion, increase in hepatic triglycerides storage and modulation of inflammatory profile. The phenotypic changes seen from chronic <jats:italic>S. boulardii<\/jats:italic> treatment were found to be broadly associated with the changes in microbioma of diabetic animals, with increased proportion in <jats:italic>Bacteroidetes, Firmicutes<\/jats:italic> and <jats:italic>Deferribacteres<\/jats:italic>, and a decreased proportion of <jats:italic>Proteobacteria<\/jats:italic> and <jats:italic>Verrucomicrobia<\/jats:italic> phylum. Thus, the data presented here show up a novel potential therapeutic role of <jats:italic>S. boulardii<\/jats:italic> for the treatment and attenuation of diabetes-induced complications.<\/jats:p>","DOI":"10.3920\/bm2019.0056","type":"journal-article","created":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T10:31:02Z","timestamp":1575455462000},"page":"901-912","source":"Crossref","is-referenced-by-count":35,"title":["Saccharomyces boulardii Tht 500101 changes gut microbiota and ameliorates hyperglycaemia, dyslipidaemia, and liver inflammation in streptozotocin-diabetic mice"],"prefix":"10.1163","volume":"10","author":[{"given":"R.C.M.F.","family":"Albuquerque","sequence":"first","affiliation":[{"name":"Federal University of S\u00e3o Paulo (Unifesp), Department of Medicine \u2013 S\u00e3o Paulo, Sp. Rua Pedro De Toledo 720 \u2013 2\u00b0 Andar, Vila Clementino, 04039-002 S\u00e3o Paulo, SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.B.P.","family":"Brand\u00e3o","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo (Unifesp), Department of Medicine \u2013 S\u00e3o Paulo, Sp. Rua Pedro De Toledo 720 \u2013 2\u00b0 Andar, Vila Clementino, 04039-002 S\u00e3o Paulo, SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.C.M.E.","family":"De Abreu","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo (Unifesp), Department of Medicine \u2013 S\u00e3o Paulo, Sp. Rua Pedro De Toledo 720 \u2013 2\u00b0 Andar, Vila Clementino, 04039-002 S\u00e3o Paulo, SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.G.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo (Unifesp), Institute of Science and Technology, Department of Science and Technology \u2013 S\u00e3o Jos\u00e9 Dos Campos, Rua Talim 330. Vila Nair, 12231-280 S\u00e3o Jos\u00e9 Dos Campos, SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.B.","family":"Santos","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo (Unifesp), Institute of Science and Technology, Department of Science and Technology \u2013 S\u00e3o Jos\u00e9 Dos Campos, Rua Talim 330. Vila Nair, 12231-280 S\u00e3o Jos\u00e9 Dos Campos, SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.N.","family":"Moreira","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo (Usp), School of Pharmaceutical Sciences, Department of Clinical and Toxicological Analyses \u2013 S\u00e3o Paulo, Avenida Professor Lineu Prestes, 580. Cidade Universit\u00e1ria, 05508-000 S\u00e3o Paulo, SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.R.","family":"Taddei","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo (Usp), School of Pharmaceutical Sciences, Department of Clinical and Toxicological Analyses \u2013 S\u00e3o Paulo, Avenida Professor Lineu Prestes, 580. Cidade Universit\u00e1ria, 05508-000 S\u00e3o Paulo, SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Aimbire","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo (Unifesp), Institute of Science and Technology, Department of Science and Technology \u2013 S\u00e3o Jos\u00e9 Dos Campos, Rua Talim 330. Vila Nair, 12231-280 S\u00e3o Jos\u00e9 Dos Campos, SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.S.","family":"Cunha","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo (Unifesp), Institute of Science and Technology, Department of Science and Technology \u2013 S\u00e3o Jos\u00e9 Dos Campos, Rua Talim 330. Vila Nair, 12231-280 S\u00e3o Jos\u00e9 Dos Campos, SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"atypb12","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","volume":"226","journal-title":"Journal of Biological Chemistry"},{"key":"atypb24","first-page":"3","volume":"43","journal-title":"Revista da Faculdade de Medicina de Ribeir\u00e3o Preto"},{"key":"atypb52","doi-asserted-by":"publisher","DOI":"10.2307\/1218190"}],"container-title":["Beneficial Microbes"],"original-title":[],"link":[{"URL":"https:\/\/brill.com\/view\/journals\/bm\/10\/8\/article-p901_8.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/brill.com\/downloadpdf\/journals\/bm\/10\/8\/article-p901_8.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/brill.com\/downloadpdf\/journals\/bm\/10\/8\/article-p901_8.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T09:28:26Z","timestamp":1713259706000},"score":1,"resource":{"primary":{"URL":"https:\/\/brill.com\/view\/journals\/bm\/10\/8\/article-p901_8.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,9]]},"references-count":3,"journal-issue":{"issue":"8"},"URL":"https:\/\/doi.org\/10.3920\/bm2019.0056","relation":{},"ISSN":["1876-2883","1876-2891"],"issn-type":[{"value":"1876-2883","type":"print"},{"value":"1876-2891","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,9]]}}}