{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:31:06Z","timestamp":1790616666954,"version":"4.1.0"},"reference-count":4,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BM"],"published-print":{"date-parts":[[2020,2,19]]},"abstract":"\n Alzheimer\u2019s disease (AD) is a progressive disease and one of the most common forms of neurodegenerative disorders. Emerging evidence is supporting the use of various strategies that modulate gut microbiota to exert neurological and psychological changes. This includes the utilisation of probiotics as a natural and dietary intervention for brain health. Here, we showed the potential AD-reversal effects of\n Lactobacillus<\/jats:italic>\n probiotics through feeding to our\n Drosophila melanogaster<\/jats:italic>\n AD model. The administration of\n Lactobacillus<\/jats:italic>\n strains was able to rescue the rough eye phenotype (REP) seen in AD-induced\n Drosophila<\/jats:italic>\n , with a more prominent effect observed upon the administration of\n Lactobacillus plantarum<\/jats:italic>\n DR7 (DR7). Furthermore, we analysed the gut microbiota of the AD-induced\n Drosophila<\/jats:italic>\n and found elevated levels of\n Wolbachia<\/jats:italic>\n . The administration of DR7 restored the gut microbiota diversity of AD-induced\n Drosophila<\/jats:italic>\n with a significant reduction in\n Wolbachia<\/jats:italic>\n \u2019s relative abundance, accompanied by an increase of\n Stenotrophomonas<\/jats:italic>\n and\n Acetobacter<\/jats:italic>\n . Through functional predictive analyses,\n Wolbachia<\/jats:italic>\n was predicted to be positively correlated with neurodegenerative disorders, such as Parkinson\u2019s, Huntington\u2019s and Alzheimer\u2019s diseases, while\n Stenotrophomonas<\/jats:italic>\n was negatively correlated with these neurodegenerative disorders. Altogether, our data exhibited DR7\u2019s ability to ameliorate the AD effects in our AD-induced\n Drosophila<\/jats:italic>\n . Thus, we propose that\n Wolbachia<\/jats:italic>\n be used as a potential biomarker for AD.\n <\/jats:p>","DOI":"10.3920\/bm2019.0086","type":"journal-article","created":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T05:04:27Z","timestamp":1578978267000},"page":"79-90","source":"Crossref","is-referenced-by-count":73,"title":["Lactobacillus probiotics improved the gut microbiota profile of a Drosophila melanogaster Alzheimer\u2019s disease model and alleviated neurodegeneration in the eye"],"prefix":"10.1163","volume":"11","author":[{"given":"F.H.P.","family":"Tan","sequence":"first","affiliation":[{"name":"School of Biological Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia."},{"name":"USM-RIKEN International Centre for Ageing Science (URICAS), Universiti Sains Malaysia, 11800 Penang, Malaysia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Liu","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China P.R."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.-Y.A.","family":"Lau","sequence":"additional","affiliation":[{"name":"School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.H.","family":"Jaafar","sequence":"additional","affiliation":[{"name":"School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia."},{"name":"USM-RIKEN International Centre for Ageing Science (URICAS), Universiti Sains Malaysia, 11800 Penang, Malaysia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.-H.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Yeungnam University, 38541 Gyeongbuk, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Azzam","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia."},{"name":"USM-RIKEN International Centre for Ageing Science (URICAS), Universiti Sains Malaysia, 11800 Penang, Malaysia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Li","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China P.R."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.-T.","family":"Liong","sequence":"additional","affiliation":[{"name":"School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia."},{"name":"USM-RIKEN International Centre for Ageing Science (URICAS), Universiti Sains Malaysia, 11800 Penang, Malaysia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"atypb3","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1242\/dev.118.2.401","volume":"118","journal-title":"Development"},{"key":"atypb21","first-page":"43","volume":"2","journal-title":"Genetics and Molecular Research Journal"},{"key":"atypb36","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.02509"},{"key":"atypb44","doi-asserted-by":"publisher","DOI":"10.1021\/jf902003a"}],"container-title":["Beneficial Microbes"],"original-title":[],"link":[{"URL":"https:\/\/brill.com\/view\/journals\/bm\/11\/1\/article-p79_8.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/brill.com\/downloadpdf\/journals\/bm\/11\/1\/article-p79_8.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/brill.com\/downloadpdf\/journals\/bm\/11\/1\/article-p79_8.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T04:43:02Z","timestamp":1713328982000},"score":1,"resource":{"primary":{"URL":"https:\/\/brill.com\/view\/journals\/bm\/11\/1\/article-p79_8.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,19]]},"references-count":4,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3920\/bm2019.0086","relation":{},"ISSN":["1876-2883","1876-2891"],"issn-type":[{"value":"1876-2883","type":"print"},{"value":"1876-2891","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,19]]}}}