{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T20:38:22Z","timestamp":1768077502343,"version":"3.49.0"},"reference-count":2,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BM"],"published-print":{"date-parts":[[2020,5,11]]},"abstract":"<jats:p>Food allergy is triggered when there is an abnormal activation of the immune system by food allergens. Currently, there is no curative therapy for this pathological condition. Due to the immunomodulatory properties of probiotics they are potential candidates as therapeutic tools for food allergy. Therefore, the aim of this study was to evaluate the probiotic effect of <jats:italic>Saccharomyces cerevisiae<\/jats:italic> UFMG A-905 (905) in an <jats:italic>in vivo<\/jats:italic> model of food allergy. Probiotic effect was assessed by clinical, histological, immunological and microbiological parameters analysis. Furthermore, we also evaluated if 905 after inactivation has an effect, as well as if such an effect is dose dependent. Our results showed that oral administration of only viable 905 promotes a significant attenuation of tissue injury and myeloperoxidase (MPO) activity levels. Moreover, the treatment reduced interleukin 17 levels, and administration of the supernatant from the yeast culture also promoted a significant decrease in MPO levels. However, considering the systemic parameters, immunoglobulin (Ig)E and IgG anti-ovalbumin, which are essentials for triggering the allergic process, there was no effect, suggesting that the yeast promotes a local but not a systemic effect in the model evaluated. In addition, we found that only high doses of viable 905 were able to attenuate the signs of inflammation. In conclusion, oral administration of 905 led to a local effect that depends on the viability of the yeast.<\/jats:p>","DOI":"10.3920\/bm2019.0113","type":"journal-article","created":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T07:26:16Z","timestamp":1586330776000},"page":"255-268","source":"Crossref","is-referenced-by-count":15,"title":["Effect of Saccharomyces cerevisiae UFMG A-905 in a murine model of food allergy"],"prefix":"10.1163","volume":"11","author":[{"given":"V.C.","family":"Miranda","sequence":"first","affiliation":[{"name":"Department of Microbiology, Federal University of Minas Gerais, Belo Horizonte, Av. Ant\u00f4nio Carlos, 6627, 30270-901 MG, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.S.","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Federal University of Minas Gerais, Belo Horizonte, Av. Ant\u00f4nio Carlos, 6627, 30270-901 MG, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.C.","family":"Assis","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology, Federal University of Minas Gerais, Av. Pres. Ant\u00f4nio Carlos 6627, Belo Horizonte, 31270-901 MG, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.M.C.","family":"Faria","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology, Federal University of Minas Gerais, Av. Pres. Ant\u00f4nio Carlos 6627, Belo Horizonte, 31270-901 MG, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.F.","family":"Quintanilha","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Federal University of Minas Gerais, Belo Horizonte, Av. Ant\u00f4nio Carlos, 6627, 30270-901 MG, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.P.","family":"Mor\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Federal University of Minas Gerais, Belo Horizonte, Av. Ant\u00f4nio Carlos, 6627, 30270-901 MG, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.R.","family":"Nicoli","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Federal University of Minas Gerais, Belo Horizonte, Av. Ant\u00f4nio Carlos, 6627, 30270-901 MG, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.C.","family":"Cara","sequence":"additional","affiliation":[{"name":"Department of Morphology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.S.","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Federal University of Minas Gerais, Belo Horizonte, Av. Ant\u00f4nio Carlos, 6627, 30270-901 MG, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"atypb34","first-page":"152","volume":"111","journal-title":"Fortschritte der Medizin"},{"key":"atypb56","first-page":"20072","volume":"8","journal-title":"International Journal of Clinical and Experimental Medicine"}],"container-title":["Beneficial Microbes"],"original-title":[],"link":[{"URL":"https:\/\/brill.com\/view\/journals\/bm\/11\/3\/article-p255_255.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/brill.com\/view\/journals\/bm\/11\/3\/article-p255_255.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/brill.com\/view\/journals\/bm\/11\/3\/article-p255_255.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T08:24:07Z","timestamp":1709108647000},"score":1,"resource":{"primary":{"URL":"https:\/\/brill.com\/view\/journals\/bm\/11\/3\/article-p255_255.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,11]]},"references-count":2,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3920\/bm2019.0113","relation":{},"ISSN":["1876-2883","1876-2891"],"issn-type":[{"value":"1876-2883","type":"print"},{"value":"1876-2891","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,11]]}}}