{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:28:16Z","timestamp":1762918096011,"version":"3.38.0"},"reference-count":1,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T00:00:00Z","timestamp":1589155200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BM"],"published-print":{"date-parts":[[2020,5,11]]},"abstract":"<jats:p>The breast milk microbiota has been described as a source of bacteria for infant gut colonisation. We studied the effect of <jats:italic>Lactobacillus fermentum<\/jats:italic> CECT5716 (Lc40) on growth and infection incidence of the infants, when the probiotic is administrated to the mothers. Moreover, whether such effects might depend on the interaction between the mother or infant microbiota and the probiotic administration. A total of 291 mother-infant pairs were studied for 16 weeks in a randomised double-blinded placebo-controlled multicentre trial. The Lc40 group (n=139) received 1 capsule\/day containing 3\u00d710<jats:sup>9<\/jats:sup> cfu Lc40; the control group (n=152) received 1 placebo (maltodextrin) capsule\/day. A positive and significant correlation of the <jats:italic>Staphylococcus<\/jats:italic> load between breast milk and infant faeces was only observed in control group. Additionally, the weight z-score of the infants whose mothers had higher values of <jats:italic>Lactobacillus<\/jats:italic> in their breast milk were significantly higher for the Lc40 group. We observed a significant lower incidence of conjunctivitis in the infants whose mothers received Lc40. A higher load of <jats:italic>Staphylococcus<\/jats:italic> in infant faeces significantly increased the risk of respiratory infections. Such incidence, under an absent or low <jats:italic>Staphylococcus<\/jats:italic> load in the faeces, was significantly 36 times higher in the infants in the control group than in the infants in the Lc40 group. However, the protective effect of Lc40 was gradually reduced as the <jats:italic>Staphylococcus<\/jats:italic> load of the milk increased. The administration of Lc40 to nursing women might influence infant growth and health but it seems to depend on its interactions with mother or infant microbiota. Registered in the US Library of Medicine (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"www.clinicaltrials.gov\">www.clinicaltrials.gov<\/jats:ext-link>): NCT02203877.<\/jats:p>","DOI":"10.3920\/bm2019.0180","type":"journal-article","created":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T08:11:58Z","timestamp":1585296718000},"page":"235-244","source":"Crossref","is-referenced-by-count":16,"title":["Effects of Lactobacillus fermentum CECT5716 Lc40 on infant growth and health: a randomised clinical trial in nursing women"],"prefix":"10.1163","volume":"11","author":[{"given":"B.","family":"Pastor-Villaescusa","sequence":"first","affiliation":[{"name":"Biosearch Life SA, Camino de Purchil 66, 18004 Granada, Spain."},{"name":"LMU \u2013 Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Division of Metabolic and Nutritional Medicine, Dr. von Hauner Children\u2019s Hospital, University of Munich Medical Centre, Lindwurmstrasse 4, 80337 Munich, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.A.","family":"Hurtado","sequence":"additional","affiliation":[{"name":"Virgen de las Nieves Maternity Hospital, Calle Ribera del Beiro s\/n, 18014 Granada, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Gil-Campos","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, Reina Sofia University Clinical Hospital, Institute Maim\u00f3nides of Biomedicine Investigation of C\u00f3rdoba (IMIBIC), University of C\u00f3rdoba, Av. Menendez Pidal s\/n, 14004 C\u00f3rdoba, Spain."},{"name":"CIBEROBN, (Physiopathology of Obesity and Nutrition CB12\/03\/30038), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Uberos","sequence":"additional","affiliation":[{"name":"San Cecilio Clinical Hospital, Av. del Conocimiento s\/n, 18016 Granada, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.A.","family":"Maldonado-Lob\u00f3n","sequence":"additional","affiliation":[{"name":"Biosearch Life SA, Camino de Purchil 66, 18004 Granada, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.P.","family":"D\u00edaz-Ropero","sequence":"additional","affiliation":[{"name":"Biosearch Life SA, Camino de Purchil 66, 18004 Granada, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Ba\u00f1uelos","sequence":"additional","affiliation":[{"name":"Biosearch Life SA, Camino de Purchil 66, 18004 Granada, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Fonoll\u00e1","sequence":"additional","affiliation":[{"name":"Biosearch Life SA, Camino de Purchil 66, 18004 Granada, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Olivares","sequence":"additional","affiliation":[{"name":"Biosearch Life SA, Camino de Purchil 66, 18004 Granada, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"_","family":"_","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"atypb35","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1542\/peds.14.5.421","volume":"14","journal-title":"Pediatrics"}],"container-title":["Beneficial Microbes"],"original-title":[],"link":[{"URL":"https:\/\/brill.com\/view\/journals\/bm\/11\/3\/article-p235_235.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/brill.com\/view\/journals\/bm\/11\/3\/article-p235_235.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/brill.com\/view\/journals\/bm\/11\/3\/article-p235_235.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T08:24:05Z","timestamp":1709108645000},"score":1,"resource":{"primary":{"URL":"https:\/\/brill.com\/view\/journals\/bm\/11\/3\/article-p235_235.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,11]]},"references-count":1,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3920\/bm2019.0180","relation":{},"ISSN":["1876-2883","1876-2891"],"issn-type":[{"type":"print","value":"1876-2883"},{"type":"electronic","value":"1876-2891"}],"subject":[],"published":{"date-parts":[[2020,5,11]]}}}