{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T23:05:57Z","timestamp":1784675157636,"version":"3.55.0"},"reference-count":43,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BM"],"published-print":{"date-parts":[[2021,11,16]]},"abstract":"<jats:p>The gut microbiota communicates with the brain through microbiota-gut-brain (MGB) and hypothalamus-pituitary-adrenal (HPA) axes and other pathways. Excessive expression of interleukin (IL)-6 is closely associated with the occurrence of the psychiatric disorders depression and dementia. Therefore, to understand whether IL-6 expression-suppressing probiotics could alleviate psychiatric disorders, we isolated IL-6 expression-inhibiting <jats:italic>Lacticaseibacillus paracasei<\/jats:italic> (formerly <jats:italic>Lactobacillus paracasei<\/jats:italic>) NK112 from the human faecal bacteria strain collection (Neurobiota Research Center, Seoul, Korea) and examined its therapeutic effect for the depression and cognitive impairment in mice. C57 BL\/6J mice with depression and cognitive impairment were prepared by exposure to <jats:italic>Escherichia coli<\/jats:italic> K1. Oral gavage of NK112 significantly alleviated K1-induced anxious, depressive, and memory-impaired behaviours in the elevated plus maze, tail-suspension and Y-maze tasks, IL-1\u03b2, IL-6, and tumour necrosis factor (TNF)-\u03b1 expression, and nuclear factor kappa beta (NF-\u03baB) activation in the hippocampus, while K1-suppressed brain-derived neurotrophic factor (BDNF) expression increased. Treatment with NK112 also improved K1-induced myeloperoxidase activity, IL-6 and TNF-\u03b1 expression, and NF-\u03baB activation in the colon and reduced K1-induced <jats:italic>Proteobacteria<\/jats:italic> population in the gut microbiota. Heat-killed NK112 and its lysate supernatant, and precipitate fractions also improved anxiety\/depression, cognitive impairment, and colitis in mice. In conclusion, NK112, even if heat-killed or lysed, alleviated K1 stress-induced colitis, anxiety\/depression, and cognitive impairment by suppressing IL-6, TNF-\u03b1, and BDNF expression through the regulation of gut microbiota and NF-\u03baB activation.<\/jats:p>","DOI":"10.3920\/bm2020.0109","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T07:54:43Z","timestamp":1631519683000},"page":"541-552","source":"Crossref","is-referenced-by-count":28,"title":["Lacticaseibacillus paracasei NK112 mitigates Escherichia coli-induced depression and cognitive impairment in mice by regulating IL-6 expression and gut microbiota"],"prefix":"10.1163","volume":"12","author":[{"given":"S.-W.","family":"Yun","sequence":"first","affiliation":[{"name":"Department of Food and Nutrition, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of 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