{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T09:32:41Z","timestamp":1746610361380,"version":"3.38.0"},"reference-count":79,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BM"],"published-print":{"date-parts":[[2021,4,12]]},"abstract":"<jats:p>Allergic contact dermatitis (ACD) is a common allergic skin disease that affects individuals subjected to different antigen exposure conditions and significantly impacts the quality of life of those affected. Numerous studies have demonstrated that probiotics suppress inflammation through immunomodulatory effects. In this study, we aimed to evaluate the effect of the probiotic <jats:italic>Bifidobacterium longum<\/jats:italic> 5<jats:sup>1A<\/jats:sup> as a preventive treatment for ACD using an oxazolone-induced murine model. We demonstrated that <jats:italic>B. longum<\/jats:italic> 5<jats:sup>1A<\/jats:sup> exerted a prophylactic effect on oxazolone-induced ACD-like skin inflammation via reductions in ear and dermal thickness and leucocyte infiltration. The administration of inactivated <jats:italic>B. longum<\/jats:italic> 5<jats:sup>1A<\/jats:sup> did not affect oxazolone-induced ACD-like skin inflammation, suggesting that the bacteria must be alive to be effective. Given that <jats:italic>B. longum<\/jats:italic> 5<jats:sup>1A<\/jats:sup> is an acetate producer, we treated mice with acetate intraperitoneally, which also prevented ear and dermal thickening. Moreover, the tissue levels of the inflammatory cytokines and chemokines interleukin (IL)-10, IL-33, tumour necrosis factor-\u03b1, chemokine (C-C motif) ligand 2\/monocyte chemoattractant protein-1 and chemokine (C-C motif) ligand 5\/RANTES were significantly reduced after probiotic treatment, but only IL-33 and IL-10 were reduced when the mice were treated with acetate. These results show that <jats:italic>B. longum<\/jats:italic> 5<jats:sup>1A<\/jats:sup> exerted a potential prophylactic effect on skin inflammation and that acetate represents one potential mechanism. However, other factors are likely involved since these two treatments do not yield the same results.<\/jats:p>\n<jats:p>\n<jats:fig position=\"float\" orientation=\"portrait\">\n<jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"ga_bm2020.0134.jpg\" position=\"float\" orientation=\"portrait\"\/><\/jats:fig>\n <\/jats:p>","DOI":"10.3920\/bm2020.0134","type":"journal-article","created":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T08:41:51Z","timestamp":1613119311000},"page":"199-210","source":"Crossref","is-referenced-by-count":8,"title":["Preventive oral supplementation with Bifidobacterium longum 51A alleviates oxazolone-induced allergic contact dermatitis-like skin inflammation in mice"],"prefix":"10.1163","volume":"12","author":[{"given":"W.R.","family":"Ribeiro","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, Institute of Environmental, Chemistry and Pharmaceutical Sciences, Federal University of S\u00e3o Paulo, R. 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