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Administration of the<jats:italic>Limosilactobacillus<\/jats:italic>strains decreased body weight gain, liver and adipose tissue weight, and glucose tolerance. Serum levels of total cholesterol, low-density lipoprotein-cholesterol, and leptin were reduced, while adiponectin increased. The administration of<jats:italic>Limosilactobacillus<\/jats:italic>strains improved the histopathological features of liver tissue, such as hepatic atrophy and inflammatory penetration, and significantly reduced the content of triglyceride in the liver.<jats:italic>Limosilactobacillus<\/jats:italic>administration discovered a significant reduction in the size of the adipocytes in the epididymal tissue.<jats:italic>Limosilactobacillus<\/jats:italic>treatment significantly reduced the expression of important regulators in lipid metabolism, including peroxisome proliferator-activated receptor \u03b3, CCAAT\/enhancer-binding protein \u03b1, fatty acid synthase (FAS), adipocyte-protein 2, and lipoprotein lipase in the epididymal tissue. Also,<jats:italic>Limosilactobacillus<\/jats:italic>lowered sterol regulatory element-binding protein 1-c and FAS in the liver tissue. Such changes in the expression of these regulators in both liver and epididymis tissue were caused by<jats:italic>Limosilactobacillus<\/jats:italic>upregulating phosphorylation of AMP-activated protein kinase and acetyl-CoA carboxylase. Therefore, we suggest that the use of the combination of<jats:italic>L. fermentum<\/jats:italic>MG4231 and MG4244, as probiotics could effectively inhibit adipogenesis and lipogenesis from preventing obesity.<\/jats:p>","DOI":"10.3920\/bm2020.0205","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T06:57:21Z","timestamp":1628146641000},"page":"479-492","source":"Crossref","is-referenced-by-count":15,"title":["Combination of Limosilactobacillus fermentum MG4231 and MG4244 attenuates lipid accumulation in high-fat diet-fed obese mice"],"prefix":"10.1163","volume":"12","author":[{"given":"S.J.","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Health Functional Materials, Duksung Women\u2019s University, 144 gil, Dobong-gu, Seoul, 01369, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.-I.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Health Functional Materials, Duksung Women\u2019s University, 144 gil, Dobong-gu, Seoul, 01369, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Food and Life Science, Inje University, Gimhae, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.-A.","family":"Jeong","sequence":"additional","affiliation":[{"name":"R&D Center, MEDIOGEN Co., Ltd., Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.-H.","family":"Kang","sequence":"additional","affiliation":[{"name":"R&D Center, MEDIOGEN Co., Ltd., Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.-H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, Duksung Women\u2019s University, 33, Samyang-ro 144-gil, Dobong-gu, Seoul, 01369, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11112690"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18061321"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90617.2008"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-016-1317-7"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2006.251"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.6467"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1007\/s13167-018-0132-z"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-020-10620-0"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000067"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.3390\/nu11030635"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-14-386"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.3390\/app8081249"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.5056\/jnm14142"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2018.4329"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-57615-5"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119628"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2011.06.003"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2002.204"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1038\/nrg.2017.72"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1159\/000481519"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2019.4627"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-019-0293-4"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb04293.x"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.3920\/BM2011.0046"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-43092-y"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.7841\/ksbbj.2018.33.3.161"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054617"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1007\/s10068-020-00819-2"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.12.121"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.3390\/nu10050643"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504978102"},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.00512"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-019-1154-9"},{"key":"atypb34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0115922"},{"key":"atypb35","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17010124"},{"key":"atypb36","unstructured":"National Research Council (NRC), 1996. 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