{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T01:42:06Z","timestamp":1769737326514,"version":"3.49.0"},"reference-count":45,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BM"],"published-print":{"date-parts":[[2021,8,30]]},"abstract":"<jats:p>The interest on plant-based fermented food is in raise in Western countries. The aim of this study was to select interleukin (IL)-10 inducing strains for the development of potential probiotic plant-based fermented foods. Departing from a collection of 52 lactic acid bacteria (LAB) strains derived from plant material, <jats:italic>in vitro<\/jats:italic> co-culture with murine macrophages allowed us to narrow down the number of candidates to 21 strains able to induce IL-10 secretion. 14 of these strains were able to promote the production of tumour necrosis factor-\u03b1 too. The capacity to induce IL-6 was used to further reduce the number of strains to 4, from which <jats:italic>Lactiplantibacillus plantarum<\/jats:italic> subsp. <jats:italic>plantarum<\/jats:italic> LpAv was selected to ferment oat and carrots. <jats:italic>L. plantarum<\/jats:italic> LpAv was able to ferment oat and carrots until reaching counts of ca. 10<jats:sup>8<\/jats:sup> and 10<jats:sup>9<\/jats:sup> cfu\/ml. Fermented oat and carrots were orally administered to mice for 10 consecutive days and challenged with a single infective dose of <jats:italic>Salmonella enterica<\/jats:italic> serovar. Typhimurium. Counts of <jats:italic>L. plantarum<\/jats:italic> LpAv in fermented carrots were 9.23\u00b10.05 cfu\/ml and 9.27\u00b10.01 cfu\/ml, at day 1 and 10 of the feeding period. Fermented carrots were able to confer enhanced protection (80% of survival) against infection, when compared to control mice (less than 25% of survival). However, <jats:italic>L. plantarum<\/jats:italic> LpAv administered as pure culture was not able to confer protection against <jats:italic>Salmonella<\/jats:italic> infection. <jats:italic>L. plantarum<\/jats:italic> LpAv was selected among 52 plant-derived LAB and it was able to ferment oat and carrots, being only fermented carrots able to confer enhanced protection against <jats:italic>Salmonella<\/jats:italic> infection. A succession of <jats:italic>in vitro<\/jats:italic> to <jats:italic>in vivo<\/jats:italic> tests is proposed as a tool to narrow down the number of candidates when searching for potential novel probiotics from a collection of autochthonous strains.<\/jats:p>","DOI":"10.3920\/bm2020.0228","type":"journal-article","created":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T13:00:36Z","timestamp":1626267636000},"page":"351-364","source":"Crossref","is-referenced-by-count":4,"title":["Narrowing down the number of potential plant-based probiotic candidates by successive in vitro, technological and in vivo assays"],"prefix":"10.1163","volume":"12","author":[{"given":"M.","family":"Puntillo","sequence":"first","affiliation":[{"name":"Instituto de Lactolog\u00eda Industrial (CONICET-UNL), Facultad de Ingenier\u00eda Qu\u00edmica, Universidad Nacional del Litoral, Santiago del Estero 2829, Santa Fe, 3000, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Spotti","sequence":"additional","affiliation":[{"name":"Instituto de Tecnolog\u00eda de Alimentos, Facultad de Ingenier\u00eda Qu\u00edmica, Universidad Nacional del Litoral, 1 de Mayo 3250, Santa Fe, 3000, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Salminen","sequence":"additional","affiliation":[{"name":"Functional Foods Forum, Faculty of Medicine, University of Turku, It\u00e4inenpitk\u00e4katu 4 A, Turku, 20014, Finland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Vinderola","sequence":"additional","affiliation":[{"name":"Instituto de Lactolog\u00eda Industrial (CONICET-UNL), Facultad de Ingenier\u00eda Qu\u00edmica, Universidad Nacional del Litoral, Santiago del Estero 2829, Santa Fe, 3000, 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