{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:07:33Z","timestamp":1773288453529,"version":"3.50.1"},"reference-count":40,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BM"],"published-print":{"date-parts":[[2021,11,16]]},"abstract":"<jats:p>Thermotolerant <jats:italic>Campylobacter<\/jats:italic> species are the leading cause of foodborne bacterial diarrheal disease worldwide. <jats:italic>Campylobacter coli<\/jats:italic>, abundant in pigs and pork products, have been identified as a source of human infection. In this study, we propose the use of <jats:italic>Lactiplantibacillus plantarum<\/jats:italic> LP5 as a probiotic to reduce colonisation of this intestinal pathogen in a murine colonisation model of <jats:italic>C. coli<\/jats:italic> DSPV458. Six-week-old adult female <jats:italic>Balb\/cCmedc<\/jats:italic> mice were housed in groups: Control, Campy and Pro-Campy. Control and Pro-Campy groups received antibiotics for 5 days and the Campy group for 12 days. Pro-Campy group was inoculated for 7 days with 8.78 log<jats:sub>10<\/jats:sub> cfu total of <jats:italic>L. plantarum<\/jats:italic> LP5 suspended in De Man, Rogosa and Sharpe broth. All groups were inoculated with 6.72 log<jats:sub>10<\/jats:sub> cfu of <jats:italic>C. coli<\/jats:italic> DSPV458 suspended in brain heart infusion broth. <jats:italic>L. plantarum<\/jats:italic> LP5 was recovered only in the Pro- Campy group. <jats:italic>C. coli<\/jats:italic> DSPV458 was recovered at higher levels in the Control and Campy groups. The differences with the Pro-Campy group were significant. As regards faeces, Control and Campy groups reached 7.41 and 7.84 log<jats:sub>10<\/jats:sub> cfu\/g, respectively, and the Pro-Campy group only 4.62 log<jats:sub>10<\/jats:sub> cfu\/g. In the caecum, Control and Campy groups reached 8.01 and 9.26 log<jats:sub>10<\/jats:sub>cfu\/g, respectively, and the Pro-Campy group only 4.51 log<jats:sub>10<\/jats:sub> cfu\/g. In the ileum, Control and Campy groups reached 3.43 and 3.26 log<jats:sub>10<\/jats:sub> cfu\/g, respectively, and the Pro-Campy group did not show detectable levels. The reduction of <jats:italic>C. coli<\/jats:italic> DSPV458 in the Pro-Campy group compared to the Control group in faeces, caecum and ileum was 99.55, 99.98 and 100%, respectively. Animals were maintained under normal health conditions, and haematological parameters were within the standard values for <jats:italic>Balb\/cCmedc<\/jats:italic>. The incorporation of a probiotic generated a protective effect in the mice colonisation model. The protective effect would also apply to intestinal colonisation by indigenous enterobacteria. Therefore, the strategy used in this study is of great importance to understand the protection mechanisms in a murine model, as well as its application in food-producing animals.<\/jats:p>","DOI":"10.3920\/bm2021.0010","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T12:32:10Z","timestamp":1633005130000},"page":"553-566","source":"Crossref","is-referenced-by-count":2,"title":["Protective effect of Lactiplantibacillus plantarum LP5 in a murine model of colonisation by Campylobacter coli DSPV458"],"prefix":"10.1163","volume":"12","author":[{"given":"M.J.","family":"Ruiz","sequence":"first","affiliation":[{"name":"Laboratory of Food Analysis \u2018Rodolfo Oscar Dalla Santina\u2019, Institute of Veterinary Science (ICiVet Litoral), National University of the Litoral \u2013 National Council of Scientific and Technical Research (UNL\/CONICET), Kreder 2805, 3080 Esperanza, Province of Santa Fe, Argentina."},{"name":"Department of Animal Health and Preventive Medicine, Faculty of Veterinary Sciences, National University of the Center of the Province of Buenos Aires, Tandil, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.E.","family":"Sirini","sequence":"additional","affiliation":[{"name":"Laboratory of Food Analysis \u2018Rodolfo Oscar Dalla Santina\u2019, Institute of Veterinary Science (ICiVet Litoral), National University of the Litoral \u2013 National Council of Scientific and Technical Research (UNL\/CONICET), Kreder 2805, 3080 Esperanza, Province of Santa Fe, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.L.","family":"Signorini","sequence":"additional","affiliation":[{"name":"Department of Public Health, Faculty of Veterinary Science, Litoral National University, Kreder 2805, 3080 Esperanza, Province of Santa Fe, Argentina."},{"name":"National Council of Scientific and Technical Research, National Institute of Agricultural Technology EEA Rafaela, Ruta 34 Km 227, 2300 Rafaela, Province of Santa Fe, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Etcheverr\u00eda","sequence":"additional","affiliation":[{"name":"Department of Animal Health and Preventive Medicine, Faculty of Veterinary Sciences, National University of the Center of the Province of Buenos Aires, Tandil, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.V.","family":"Zbrun","sequence":"additional","affiliation":[{"name":"Laboratory of Food Analysis \u2018Rodolfo Oscar Dalla Santina\u2019, Institute of Veterinary Science (ICiVet Litoral), National University of the Litoral \u2013 National Council of Scientific and Technical Research (UNL\/CONICET), Kreder 2805, 3080 Esperanza, Province of Santa Fe, Argentina."},{"name":"Department of Public Health, Faculty of Veterinary Science, Litoral National University, Kreder 2805, 3080 Esperanza, Province of Santa Fe, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.P.","family":"Soto","sequence":"additional","affiliation":[{"name":"Laboratory of Food Analysis \u2018Rodolfo Oscar Dalla Santina\u2019, Institute of Veterinary Science (ICiVet Litoral), National University of the Litoral \u2013 National Council of Scientific and Technical Research (UNL\/CONICET), Kreder 2805, 3080 Esperanza, Province of Santa Fe, Argentina."},{"name":"Department of Public Health, Faculty of Veterinary Science, Litoral National University, Kreder 2805, 3080 Esperanza, Province of Santa Fe, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.A.","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Laboratory of Food Analysis \u2018Rodolfo Oscar Dalla Santina\u2019, Institute of Veterinary Science (ICiVet Litoral), National University of the Litoral \u2013 National Council of Scientific and Technical Research (UNL\/CONICET), Kreder 2805, 3080 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