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The high-fat diet (HFD) starting from weaned period led to higher levels of visceral fat and a significantly heavier liver in male mice. Moreover, HFD resulted in disorders of glucose and lipid metabolism, changes in insulin-resistance indices (IR), and an increase in serum insulin and leptin in mice. Of note, 15 weeks use of <jats:italic>Lacticaseibacillus paracasei<\/jats:italic> N1115 decreased visceral fat, liver weight, serum levels of insulin and leptin, and IR and alleviated lipid dysmetabolism. HFD resulted in a significant increase in the relative abundance of <jats:italic>Bilophila<\/jats:italic>, <jats:italic>Lachnoclostridium<\/jats:italic>, and <jats:italic>Blautia<\/jats:italic> and may decrease the faecal short-chain fatty acid (SCFA) levels in mice; in turn, treatment with the potential probiotic strain <jats:italic>L. paracasei<\/jats:italic> N1115 protected mice from these negative effects. HFD significant impaired the physiology of the host especially in male mice and dramatically changed the composition of host gut microbiota. However, the use of potential probiotic strain, such as <jats:italic>L. paracasei<\/jats:italic> N1115, may prevent these impairments due to HFD via effecting the host gut microbiota and SCFA.<\/jats:p>","DOI":"10.3920\/bm2021.0171","type":"journal-article","created":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T14:40:02Z","timestamp":1665758402000},"page":"407-416","source":"Crossref","is-referenced-by-count":9,"title":["Long-term use of Lacticaseibacillus paracasei N1115 from early life alleviates high-fat-diet-induced obesity and dysmetabolism in mice"],"prefix":"10.1163","volume":"13","author":[{"given":"Z.H.","family":"Miao","sequence":"first","affiliation":[{"name":"Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, No. 16, 3rd section, South Renmin Road, 610041 Chengdu, Sichuan, China P.R."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.N.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, No. 16, 3rd section, South Renmin Road, 610041 Chengdu, Sichuan, China P.R."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, No. 16, 3rd section, South Renmin Road, 610041 Chengdu, Sichuan, China P.R."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.Q.","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, No. 16, 3rd section, South Renmin Road, 610041 Chengdu, Sichuan, China P.R."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.T.","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, No. 16, 3rd section, South Renmin Road, 610041 Chengdu, Sichuan, China P.R."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.J.","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, No. 16, 3rd section, South Renmin Road, 610041 Chengdu, Sichuan, China P.R."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.J","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food and Biology Hebei University of Science and Technology, 36th Shitong Road, 050221 Shijiazhuang, Hebei, China P.R."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.H.","family":"Qi","sequence":"additional","affiliation":[{"name":"Basic Research and Development Center, Hebei Inatrual Bio-tech Co. 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