{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T14:17:49Z","timestamp":1786544269706,"version":"build-2736575974"},"reference-count":43,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T00:00:00Z","timestamp":1681430400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BM"],"published-print":{"date-parts":[[2023,4,14]]},"abstract":"<jats:p>We investigated the effects of heat-killed <jats:italic>Lactobacillus helveticus<\/jats:italic> MCC1848 on daily mood states in healthy young adults. Participants (n=58) were randomised to receive heat-killed <jats:italic>L. helveticus<\/jats:italic> MCC1848 powder or placebo powder for 4 weeks. During the study period, adverse events were recorded in the participant diary. Mood states were assessed before and 2 and 4 weeks after initiation of the intervention. The primary outcomes were the shortened version of the Profile of Mood States 2 (POMS 2) scores. Secondary outcomes included other mood state (State-Trait Anxiety Inventory (STAI); visual analogue scale (VAS)), quality of life (acute form of the SF-36v2), sleep (Athens Insomnia Scale (AIS)) and fatigue (Chalder Fatigue Scale (CFS)) scores. Four weeks of heat-killed <jats:italic>L. helveticus<\/jats:italic> MCC1848 intake, compared to placebo, significantly improved the shortened version of the POMS 2 \u2018friendliness\u2019 and the VAS \u2018relaxed\u2019 scores, which are two indicators of positive mood states. On the other hand, heat-killed <jats:italic>L. helveticus<\/jats:italic> MCC1848 intake had no significant effects on negative mood state items (e.g. anger, nervousness, confusion) assessed by the shortened version of the POMS 2, STAI and VAS. AIS and CFS scores also showed no significant differences. No adverse effects were observed with 4 weeks of heat-killed <jats:italic>L. helveticus<\/jats:italic> MCC1848 intake. These results suggest that daily consumption of heat-killed <jats:italic>L. helveticus<\/jats:italic> MCC1848 is safe and has the potential to improve positive mood states.<\/jats:p>\n<jats:p>\n<jats:bold>UMIN Clinical Trial Registry<\/jats:bold>: UMIN000043697.<\/jats:p>","DOI":"10.3920\/bm2022.0048","type":"journal-article","created":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T07:18:30Z","timestamp":1680851910000},"page":"109-118","source":"Crossref","is-referenced-by-count":22,"title":["Heat-killed Lactobacillus helveticus improves mood states: a randomised, double-blind, placebo-controlled study"],"prefix":"10.1163","volume":"14","author":[{"given":"N.","family":"Mutoh","sequence":"first","affiliation":[{"name":"Food Ingredients & Technology Institute, Morinaga Milk Industry Co., Ltd., 1-83, 5-Chome, Higashihara, 2528583 Zama-city, Kanagawa, 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