{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:42:16Z","timestamp":1791196936542,"version":"4.1.0"},"reference-count":51,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T00:00:00Z","timestamp":1681430400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BM"],"published-print":{"date-parts":[[2023,4,14]]},"abstract":"<jats:p>This systematic review and meta-analysis assessed the impact of probiotic supplementation on treating chronic periodontal (CP) disease based on clinical and microbiological findings. Four databases were searched: Medline, Embase, Cochrane Library, and the Web of Science databases. The references to relevant studies were also manually searched. Analyses were conducted using the Review Manager 5.2 software, while the quality of randomised controlled trials was assessed with the Cochrane Risk of Bias tool. In total, 19 studies were included in the meta-analysis. Pooled results revealed that the adjuvant use of probiotics in the treatment of patients with periodontal disease was largely associated with good clinical efficacy. Resulting in statistically significant improvements in plaque index (<jats:italic>P<\/jats:italic>&lt;0.05), periodontal probing depth (<jats:italic>P<\/jats:italic>&lt;0.05), clinical attachment level (<jats:italic>P<\/jats:italic>&lt;0.05), gingival index (<jats:italic>P<\/jats:italic>&lt;0.05), bleeding on probing (<jats:italic>P<\/jats:italic>&lt;0.05), deep probing depth (<jats:italic>P<\/jats:italic>&lt;0.05), and levels of subgingival microbes (<jats:italic>P<\/jats:italic>&lt;0.05) following probiotic supplementation. In summary, the results of this meta-analysis suggest that the administration of probiotics together with scaling and root planing can somewhat improve CP patient clinical outcomes and reduce levels of periodontal pathogens. However, more comprehensive experiments are needed to standardise probiotics and maximise their adjuvant therapy.<\/jats:p>","DOI":"10.3920\/bm2022.0056","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T11:03:05Z","timestamp":1677668585000},"page":"95-108","source":"Crossref","is-referenced-by-count":24,"title":["Probiotic adjuvant treatment in combination with scaling and root planing in chronic periodontitis: a systematic review and meta-analysis"],"prefix":"10.1163","volume":"14","author":[{"given":"J.","family":"Li","sequence":"first","affiliation":[{"name":"Jiamusi University, Jiamusi City 154000, Heilongjiang Province, China P.R."},{"name":"Jiamusi University Affiliated Stomatological Hospital, Jiamusi City 154004, Heilongjiang Province, China P.R."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Zhao","sequence":"additional","affiliation":[{"name":"Jiamusi University Affiliated Stomatological Hospital, Jiamusi City 154004, Heilongjiang Province, China P.R."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.M.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiamusi University, Jiamusi City 154000, Heilongjiang Province, China P.R."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.F.","family":"Zhu","sequence":"additional","affiliation":[{"name":"Jiamusi University, Jiamusi City 154000, Heilongjiang Province, China P.R."},{"name":"Jiamusi University Affiliated Stomatological Hospital, Jiamusi City 154004, Heilongjiang Province, China P.R."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"atypb1","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/adj.12568","volume":"63","journal-title":"Australian Dental Journal"},{"key":"atypb2","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1055\/s-0040-1709924","volume":"14","journal-title":"European Journal of Dentistry"},{"key":"atypb3","doi-asserted-by":"crossref","first-page":"55","DOI":"10.17096\/jiufd.90144","volume":"49","journal-title":"Journal of Istanbul University Faculty of Dentistry"},{"key":"atypb4","first-page":"585","volume":"75","journal-title":"Journal Journal of the Canadian Dental Association"},{"key":"atypb5","first-page":"67","volume":"18","journal-title":"Journal of the International Academy of Periodontology"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.6269"},{"key":"atypb7","first-page":"191","volume":"11","journal-title":"Oral and Implantology"},{"key":"atypb8","first-page":"ED000142","volume":"10","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"atypb9","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1177\/0022034510377793","volume":"89","journal-title":"Journal of Dental Research"},{"key":"atypb10","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/jre.12436","volume":"52","journal-title":"Journal of Periodontal Research"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.21203\/rs.2.18163\/v2"},{"key":"atypb12","doi-asserted-by":"crossref","first-page":"S242","DOI":"10.1016\/S1590-8658(07)60003-6","volume":"38","journal-title":"Digestive and Liver Disease"},{"key":"atypb13","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","volume":"343","journal-title":"BMJ"},{"key":"atypb14","doi-asserted-by":"crossref","first-page":"101397","DOI":"10.1016\/j.jebdp.2020.101397","volume":"20","journal-title":"Journal of Evidence Based Dental Practice"},{"key":"atypb15","doi-asserted-by":"crossref","first-page":"31","DOI":"10.58397\/ashkmdc.v24i1.24","volume":"24","journal-title":"Annals of the Abbasi Shaheed Hospital & Karachi Medical & Dental College"},{"key":"atypb16","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1902\/jop.2015.140612","volume":"86","journal-title":"Journal of Periodontology"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12995"},{"key":"atypb18","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/prd.12337","volume":"84","journal-title":"Periodontology 2000"},{"key":"atypb19","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/odi.12428","volume":"22","journal-title":"Oral Diseases"},{"key":"atypb20","doi-asserted-by":"crossref","first-page":"99","DOI":"10.5114\/ceji.2021.104412","volume":"46","journal-title":"Central-European Journal of Immunology"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1080\/13102818.2019.1632740"},{"key":"atypb22","unstructured":"Laleman, I. and Teughels, W., 2015. Probiotics in the dental practice: a review. Quintessence International. Quintessence International 46: 255-264. https:\/\/doi.org\/10.3290\/j.qi.a33182"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13198"},{"key":"atypb24","doi-asserted-by":"crossref","first-page":"905","DOI":"10.5851\/kosfa.2021.e57","volume":"41","journal-title":"Food Science of Animal Resources"},{"key":"atypb25","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/jcpe.12545","volume":"43","journal-title":"Journal of Clinical Periodontology"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01392.x"},{"key":"atypb27","first-page":"1381","volume":"10","journal-title":"Drug Invention Today"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2007.01386.x"},{"key":"atypb29","first-page":"1021","volume":"8","journal-title":"Research Journal of Pharmaceutical, Biological and Chemical Sciences"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-4-1"},{"key":"atypb31","doi-asserted-by":"crossref","first-page":"6463","DOI":"10.1007\/s00253-019-09978-7","volume":"103","journal-title":"Applied Microbiology and Biotechnology"},{"key":"atypb32","first-page":"j2835","volume":"357","journal-title":"BMJ"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.20-0194"},{"key":"atypb34","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13329"},{"key":"atypb35","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1111\/jcpe.13191","volume":"46","journal-title":"Journal of Clinical Periodontology"},{"key":"atypb36","doi-asserted-by":"publisher","DOI":"10.4103\/2279-042X.179568"},{"key":"atypb37","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1034\/j.1600-0757.2002.280104.x","volume":"28","journal-title":"Periodontology"},{"key":"atypb38","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s12602-017-9296-4","volume":"10","journal-title":"Probiotics and Antimicrobial Proteins"},{"key":"atypb39","doi-asserted-by":"publisher","DOI":"10.1086\/523341"},{"key":"atypb40","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2005.02.003"},{"key":"atypb41","first-page":"595","volume":"7","journal-title":"Journal of Clinical and Diagnostic Research"},{"key":"atypb42","first-page":"g7647","volume":"349","journal-title":"BMJ Clinical Research"},{"key":"atypb43","first-page":"64","volume":"12","journal-title":"International Journal of Applied Pharmaceutics"},{"key":"atypb44","unstructured":"Song, D. and Liu, X.R., 2020. Role of probiotics containing Lactobacillus reuteri in adjunct to scaling and root planing for management of patients with chronic periodontitis: a meta-analysis. European Review for Medical and Pharmacological Sciences 24: 4495-4505. https:\/\/doi.org\/10.26355\/eurrev_202004_21032"},{"key":"atypb45","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12387"},{"key":"atypb46","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12155"},{"key":"atypb47","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01665.x"},{"key":"atypb48","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2012.734404"},{"key":"atypb49","doi-asserted-by":"publisher","DOI":"10.3402\/jom.v2i0.5344"},{"key":"atypb50","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1002\/JPER.19-0464","volume":"91","journal-title":"Journal of Periodontology"},{"key":"atypb51","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1089\/pho.2010.2762","volume":"30","journal-title":"Photomedicine and Laser Surgery"}],"container-title":["Beneficial Microbes"],"original-title":[],"link":[{"URL":"https:\/\/brill.com\/view\/journals\/bm\/14\/2\/article-p95_1.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/brill.com\/downloadpdf\/journals\/bm\/14\/2\/article-p95_1.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/brill.com\/downloadpdf\/journals\/bm\/14\/2\/article-p95_1.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T08:40:59Z","timestamp":1713343259000},"score":1,"resource":{"primary":{"URL":"https:\/\/brill.com\/view\/journals\/bm\/14\/2\/article-p95_1.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,14]]},"references-count":51,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3920\/bm2022.0056","relation":{},"ISSN":["1876-2883","1876-2891"],"issn-type":[{"value":"1876-2883","type":"print"},{"value":"1876-2891","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,14]]}}}