{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:42:22Z","timestamp":1783122142664,"version":"3.54.6"},"reference-count":49,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BM"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Probiotics represent a promising tool to improve metabolic health, including lipid profiles and cholesterol levels. Modulation of the gut microbiome and the endocannabinoidome \u2013 two interrelated systems involved in several metabolic processes influenced by probiotics \u2013 has been proposed as a potential mechanism of action. This study establishes the impact of probiotics on metabolic health, gut microbiota composition and endocannabinoidome mediators in an animal model of hypercholesterolaemia. Syrian hamsters were fed either a low-fat low-cholesterol or high-fat high-cholesterol (HFHC) diet to induce hypercholesterolaemia and gavaged for 6 weeks with either <jats:italic>Lactobacillus acidophilus<\/jats:italic> CL1285, <jats:italic>Lactiplantibacillus plantarum<\/jats:italic> CHOL-200 or a combination of the two. Globally, probiotic interventions ameliorated, at least partially, lipid metabolism in HFHC-fed hamsters. The interventions, especially those including <jats:italic>L. acidophilus<\/jats:italic>, modified the gut microbiota composition of the small intestine and caecum in ways suggesting reversal of HFHC-induced dysbiosis. Several associations were observed between changes in gut microbiota composition and endocannabinoidome mediators following probiotic interventions and both systems were also associated with improved metabolic health parameters. For instance, potential connexions between the <jats:italic>Eubacteriaceae<\/jats:italic> and <jats:italic>Deferribacteraceae<\/jats:italic> families, levels of 2\u2011palmitoylglycerol, 2\u2011oleoylglycerol, 2\u2011linoleoylglycerol or 2\u2011eicosapentaenoylglycerol and improved lipid profiles were found. Altogether, our results suggest a potential crosstalk between gut microbiota and the endocannabinoidome in driving metabolic benefits associated with probiotics, especially those including <jats:italic>L. acidophilus<\/jats:italic>, in an animal model of hypercholesterolaemia.<\/jats:p>","DOI":"10.3920\/bm2022.0080","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T06:35:41Z","timestamp":1686119741000},"page":"223-237","source":"Crossref","is-referenced-by-count":2,"title":["Probiotic interventions promote metabolic health in high fat-fed hamsters in association with gut microbiota and endocannabinoidome alterations"],"prefix":"10.1163","volume":"14","author":[{"given":"S.","family":"Lacroix","sequence":"first","affiliation":[{"name":"Centre Nutrition, Sant\u00e9 et Soci\u00e9t\u00e9 (NUTRISS), Institut sur la nutrition et les aliments fonctionnels (INAF), Universit\u00e9 Laval, 2440 boulevard Hochelaga, Qu\u00e9bec City, Qu\u00e9bec G1V 0A6, 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