{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T10:31:11Z","timestamp":1777717871353,"version":"3.51.4"},"reference-count":23,"publisher":"SLACK, Inc.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Ann"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:sec>\n            <jats:title>CME Educational Objectives<\/jats:title>\n            <jats:list list-type=\"order\">\n              <jats:list-item>\n                <jats:label>1.<\/jats:label>\n                <jats:p>Understand the prevalence and severity of childhood food allergy in the United States.<\/jats:p>\n              <\/jats:list-item>\n              <jats:list-item>\n                <jats:label>2.<\/jats:label>\n                <jats:p>Describe the geographic distribution of childhood food allergy.<\/jats:p>\n              <\/jats:list-item>\n              <jats:list-item>\n                <jats:label>3.<\/jats:label>\n                <jats:p>Appreciate the economic impact of childhood food allergy on families and the US health care system.<\/jats:p>\n              <\/jats:list-item>\n            <\/jats:list>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>Food allergy is a public health problem that affects nearly 6 million children in the United States. The extent to which children, families, and communities live with food allergies varies as much as the range of clinical symptoms associated with the disease itself. Food allergy is defined as the reproducible adverse event that elicits a pathologic immunoglobulin E (IgE)-mediated or non\u2013IgE-mediated reaction. Once an allergic child ingests a specific food allergen, the reaction can result in clinical symptoms ranging from mild hives to life-threatening anaphylaxis.<\/jats:p>\n            <jats:p>Not surprisingly, food allergies have been shown to limit social interactions and impair children\u2019s quality of life due to the ubiquity of food where children live, learn, and play. To ensure the safety of our children, the development of sound policy, clinical practice, and health programs must be informed by current research characterizing childhood food allergy at the population level. To set the stage for understanding the current evidence base, this article reviews: 1) epidemiology of childhood food allergy; 2) severity of symptoms; 3) geographic distribution of childhood food allergy; 4) tolerance; 5) economic impact of childhood food allergy; and 6) future directions in childhood food allergy epidemiological research.<\/jats:p>\n          <\/jats:sec>","DOI":"10.3928\/00904481-20130522-08","type":"journal-article","created":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T17:35:32Z","timestamp":1369848932000},"source":"Crossref","is-referenced-by-count":30,"title":["Epidemiology of Childhood Food Allergy"],"prefix":"10.3928","volume":"42","author":[{"given":"Ashley A.","family":"Dyer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruchi","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2308","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-0204"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-1210"},{"key":"e_1_3_1_4_2","volume-title":"Food Allergy: Adverse Reactions to Foods and Food Additives","author":"Keeton RW","year":"2009","unstructured":"Keeton RW, Baldwin JL, Singer AM. Pharmacologic food reactions. In: Food Allergy: Adverse Reactions to Foods and Food Additives. 4th ed. Oxford, UK: Blackwell Publishing; 2009.","edition":"4"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.07.026"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1474"},{"issue":"6","key":"e_1_3_1_7_2","first-page":"S1","article-title":"Guidelines for the Diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel","volume":"2010","author":"NIAID-Sponsored Expert Panel","unstructured":"NIAID-Sponsored Expert PanelBoyce JA, Amal Assa\u2019ad, Burks AW, et al. Guidelines for the Diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel. J Allergy Clin Immunol. 2010;126(6 Suppl).S1\u201358.","journal-title":"J Allergy Clin Immunol"},{"issue":"8","key":"e_1_3_1_8_2","first-page":"536","article-title":"Food-induced anaphylaxis: who, what, why, and where?","volume":"37","author":"Shah E","year":"2008","unstructured":"Shah E, Pongracic J. Food-induced anaphylaxis: who, what, why, and where? Pediatr Ann. 2008;37(8):536\u2013541.","journal-title":"Pediatr Ann"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.03.009"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/0009922812448526"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.03.049"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.08.023"},{"key":"e_1_3_1_13_2","volume-title":"Childhood food allergy tolerance and associated factors","author":"Gupta RS LC","unstructured":"Gupta RS LC, Smith B, Pongracic J, Holl JL. Childhood food allergy tolerance and associated factors. Paper presented at: American College of Allergy, Asthma & Immunology Annual Scientific Meeting; Nov. 8, 2012; Anaheim, CA."},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.112129"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1517"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.09.002"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.09.040"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60513-3"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.12.994"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.2478\/v10039-011-0008-0"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.02.028"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2010.01040.x"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.03.013"},{"key":"e_1_3_1_24_2","volume-title":"The high economic burden of childhood food allergy in the United States","author":"Gupta RS BL","unstructured":"Gupta RS BL, Holdford D, Dyer A, Pongracic J, Holl JL. The high economic burden of childhood food allergy in the United States. Paper presented at: European Academy of Allergy and Clinical Immunology Annual Congress; June 16, 2012; Geneva, Switzerland."}],"container-title":["Pediatric Annals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.healio.com\/doiresolver?doi=10.3928\/00904481-20130522-08","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T23:26:05Z","timestamp":1683069965000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.healio.com\/doi\/10.3928\/00904481-20130522-08"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.3928\/00904481-20130522-08"],"URL":"https:\/\/doi.org\/10.3928\/00904481-20130522-08","relation":{},"ISSN":["0090-4481","1938-2359"],"issn-type":[{"value":"0090-4481","type":"print"},{"value":"1938-2359","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}