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Social learning (environmental factors) and maladaptive coping predispose children to develop IBS with greater disability and more frequent medical consultations. Early-life events constitute an additional risk factor for the development of IBS and other functional gastrointestinal disorders (FGIDs). Children with a history of cow\u2019s milk protein hypersensitivity or abdominal surgeries have a higher prevalence of IBS and other FGIDs years later. IBS frequently follows an episode of acute gastrointestinal inflammation (infectious or non-infectious).<\/jats:p>\n          <jats:p>This article discusses the importance, known pathophysiological mechanisms, clinical approach, and evidence-based therapeutic options for the management of IBS in children and adolescents.<\/jats:p>","DOI":"10.3928\/00904481-20140325-08","type":"journal-article","created":{"date-parts":[[2014,8,19]],"date-time":"2014-08-19T19:33:02Z","timestamp":1408476782000},"source":"Crossref","is-referenced-by-count":21,"title":["Pediatric IBS: An Overview on Pathophysiology, Diagnosis and Treatment"],"prefix":"10.3928","volume":"43","author":[{"given":"Ashish","family":"Chogle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stijn","family":"Mintjens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Saps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2308","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.08.063"},{"issue":"3","key":"e_1_3_1_3_2","first-page":"237","article-title":"Rome III: New standard for functional gastrointestinal disorders. 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