{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T05:48:56Z","timestamp":1772776136495,"version":"3.50.1"},"reference-count":104,"publisher":"SLACK, Inc.","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthopedics"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:p>abstract<\/jats:p><jats:p>Despite significant advances in intraoperative antimicrobial procedures, deep wound infection remains the most serious complication associated with primary, cemented total joint arthroplasty. A systematic review was conducted to evaluate studies o\u00ed antibiotic bone cement prophylaxis for reducing the risk of deep wound infection. The literature included 22 articles providing estimates of the prophylactic effectiveness of antibiotic cement. In reducing deep wound infection, antibiotic cement was consistently superior to plain cement, similar to systematic antiobiotics, and independent and additive in effect when combined with other prophylactic measures. Randomized controlled trials in particular had important methodological limitations. However, the collective results nearly unanimously favored prophylactic use of antibiotic cement in primary arthoplasty procedures.<\/jats:p>","DOI":"10.3928\/0147-7447-20051101-13","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T04:37:55Z","timestamp":1619066275000},"page":"1334-1345","source":"Crossref","is-referenced-by-count":40,"title":["Reducing the Risk of Deep Wound Infection in Primary Joint Arthroplasty With Antibiotic Bone Cement"],"prefix":"10.3928","volume":"28","author":[{"given":"Jon E","family":"Block","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harrison A","family":"Stubbs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2308","reference":[{"key":"e_1_3_1_2_1","doi-asserted-by":"crossref","unstructured":"1. NIH consensus conference: total Mp replacement. NIH Consensus Development Panel on Total Hip Replacement. JAMA. 1995; 273:1950-1956.","DOI":"10.1001\/jama.273.24.1950"},{"key":"e_1_3_1_3_1","unstructured":"2. Brause BD. Infections with prostheses in bones and joints. In: Mandell GL Bennett JE Dolin R eds. Principles and Practice of Infectious Diseases. 4ih ed. New York NY: Churchill Livingstone Inc; 1995:1051-1055."},{"key":"e_1_3_1_4_1","doi-asserted-by":"crossref","unstructured":"3. Deacon JM Pagliaro AJ Zel\u00eccof SB Horowitz HW. Prophylactic use of antibiotics for procedures after total joint replacement. J Bone Joint Surg Am. 1996; 78:1755-1770.","DOI":"10.2106\/00004623-199611000-00020"},{"key":"e_1_3_1_5_1","doi-asserted-by":"crossref","unstructured":"4. Cristina AG. Implant failure and the immuno-incompetent fibre-inflammatory zone. ClinOrthop. 1994; 298;106-118.","DOI":"10.1097\/00003086-199401000-00016"},{"key":"e_1_3_1_6_1","doi-asserted-by":"crossref","unstructured":"5. Brause BD. Prosthetic joint infections. Curr Opin Rheumatol. 1989; 1:194-198.","DOI":"10.1097\/00002281-198901020-00011"},{"key":"e_1_3_1_7_1","doi-asserted-by":"crossref","unstructured":"6. Petty W. The effect of methylmethacrylate on the bacterial inhibiting properties of normal human serum. Clin Orthop. 1978; 132:266278.","DOI":"10.1097\/00003086-197805000-00044"},{"key":"e_1_3_1_8_1","doi-asserted-by":"crossref","unstructured":"7. Petty W. The effect of methylmethacrylate on bacterial phagocytosis and killing by human polymorphonuciear leukocytes. J Bone Joint Surg Am. 1978; 60:752-757.","DOI":"10.2106\/00004623-197860060-00004"},{"key":"e_1_3_1_9_1","doi-asserted-by":"crossref","unstructured":"8. Petty W Spanier S Shuster JJ Silverthorne C. The influence of skeletal implants on incidence of infection. Experiments in a canine model. J Bone Joint Surg Am. 1985: 67: 12361244.","DOI":"10.2106\/00004623-198567080-00015"},{"key":"e_1_3_1_10_1","doi-asserted-by":"crossref","unstructured":"9. Lidwell OM. Lowbury EJ Whyte W Blowers R Stanley SJ Lowe D. Effect of ultraclean air in operating rooms on deep sepsis in the joint after total hip or knee replacement: a randomised study. Br Mea J (Clin Res Ed). 1982; 285:10-14.","DOI":"10.1136\/bmj.285.6334.10"},{"key":"e_1_3_1_11_1","doi-asserted-by":"crossref","unstructured":"10. Lidwell OM Lowbury EJ Whyte W Blowers R Stanley SJ Lowe D Infection and sepsis after operations for total hip or kneejoint replacement: influence of uitraclean air prophylactic antibiotics and other factors. J Hyg (Land). 1984; 93:505-529.","DOI":"10.1017\/S0022172400065098"},{"key":"e_1_3_1_12_1","doi-asserted-by":"crossref","unstructured":"11. Garvin KL Hanssen AD. Infection after total hip arthroplasty. Past present and future. J Bone Joint Surg Am. 1995; 77:1576-1588.","DOI":"10.2106\/00004623-199510000-00015"},{"key":"e_1_3_1_13_1","doi-asserted-by":"crossref","unstructured":"12. Masterson EL Masri BA Duncan CP. Treatment of infection at the site of total hip replacement. J Bone Joint Surg Am. 1997; 79:1740-1749.","DOI":"10.2106\/00004623-199711000-00017"},{"key":"e_1_3_1_14_1","doi-asserted-by":"crossref","unstructured":"13. Hanssen AD Rand JA. Evaluation and treatment of infection at the site of a total hip or knee arthroplasty. J Bone Joint Surg Am. 1998:80:910-922.","DOI":"10.2106\/00004623-199806000-00016"},{"key":"e_1_3_1_15_1","unstructured":"14. Laveraia CJ Drakeford MK. Tsao AK Gittelsohn A Krackow KA. Hungerford DS. Revision and primary hip and knee arthroplasty. A cost analysis. Clin Orthop. 1995; 311:136141."},{"key":"e_1_3_1_16_1","doi-asserted-by":"crossref","unstructured":"15. Gaine WJ Ramamohan NA Hussein NA Hullin MG McCreath SW. Wound infection in hip and knee arthroplasty. J Bone Joint Surg Br. 2000; 82:561 -565.","DOI":"10.1302\/0301-620X.82B4.0820561"},{"key":"e_1_3_1_17_1","doi-asserted-by":"crossref","unstructured":"16. Dreghorn CR Hamblen DL. Revision arthroplasty: a high price to pay. BMJ. 1989: 298:648-649.","DOI":"10.1136\/bmj.298.6674.648"},{"key":"e_1_3_1_18_1","unstructured":"17. Sculco TP The economic impact of infected total joint arthroplasty. instr Course Led. 1993; 42:349-351."},{"key":"e_1_3_1_19_1","doi-asserted-by":"crossref","unstructured":"18. lorio R Healy WL Richards JA. Comparison of the hospital cost of primary and revision total hip arthroplasty after cost containment. Orthopedics. 1999:22:185-189.","DOI":"10.3928\/0147-7447-19990201-07"},{"key":"e_1_3_1_20_1","doi-asserted-by":"crossref","unstructured":"19. lorio R Healy WL Richards JA. Comparison of the hospital cost of primary and revision total knee arthroplasty after cosi containment. Orthopedics. 1999:22:195-199.","DOI":"10.3928\/0147-7447-19990201-08"},{"key":"e_1_3_1_21_1","doi-asserted-by":"crossref","unstructured":"20. Duncan CP Masri BA. The role of antibioticloaded cement in the treatment of an infection after a hip replacement. J Bone Joint Surg Am. 1994; 76:1742-1751.","DOI":"10.2106\/00004623-199411000-00020"},{"key":"e_1_3_1_22_1","doi-asserted-by":"crossref","unstructured":"21. Furnes A Lie SA Havelin LI. Engesaeter LB. Vollset SE. The economic impact of failures in total hip replacement surgery: 28 997 cases from the Norwegian Arthroplasly Register 1987-1993. Acta Orthop Scand. 1996; 67:115-121.","DOI":"10.3109\/17453679608994653"},{"key":"e_1_3_1_23_1","unstructured":"22. Hanssen AD Osmon DR. The use of prophylactic antimicrobial agents during and after hip arthroplasty. Clin Orthop. 1 999; 369: 1 24138."},{"key":"e_1_3_1_24_1","doi-asserted-by":"crossref","unstructured":"23. Adams K. Couch L. Cierny G. Calhoun J Mader JT. In vitro and in vivo evaluation of antibiotic diffusion from antibiotic -impregnated potymethylmethacrylate beads. Clin Orthop. 1992:278:244-252.","DOI":"10.1097\/00003086-199205000-00037"},{"key":"e_1_3_1_25_1","doi-asserted-by":"crossref","unstructured":"24. Lyons VO. Henry SL Faghiri M Seligson D. Bacterial adherence to plain and tobramycinladen polymethylmethacrylate beads. Clin Orthop 1992; 278:260-264.","DOI":"10.1097\/00003086-199205000-00039"},{"key":"e_1_3_1_26_1","doi-asserted-by":"crossref","unstructured":"25. Nijhof MW Dhert WJ. Fleer A Vogely HC. Verbout AJ. Prophylaxis of implant-related siaphylococcal infections using tobramycincontaining bone cement. J Biomed Mater Res. 2000; 52:754-761.","DOI":"10.1002\/1097-4636(20001215)52:4<754::AID-JBM21>3.0.CO;2-#"},{"key":"e_1_3_1_27_1","doi-asserted-by":"crossref","unstructured":"26. Nijhof MW Stallmann HP Vogely HC. et al. Prevention of infection with tobramycin-containing bone cement or systemic cefazolin in an animal model. J Biomed Mater Res. 2000; 52:709-715.","DOI":"10.1002\/1097-4636(20001215)52:4<709::AID-JBM16>3.0.CO;2-W"},{"key":"e_1_3_1_28_1","doi-asserted-by":"crossref","unstructured":"27. Oga M Arizono T. Sugioka Y. Inhibition of bacterial adhesion by tobramycin-impregnated PMMA bone cement. Acta Orthop Scand. 1992; 63:301-304.","DOI":"10.3109\/17453679209154787"},{"key":"e_1_3_1_29_1","doi-asserted-by":"crossref","unstructured":"28. Scott CP Higham PA Dumblelon JH. Effectiveness of bone cemeni containing tobramycin. An in vitro susceptibility study of 99 organisms found in infected joint arthroplasty. J Bone Joint Surg Br. 1999: 81:440-443.","DOI":"10.1302\/0301-620X.81B3.0810440"},{"key":"e_1_3_1_30_1","doi-asserted-by":"crossref","unstructured":"29. Mader JT Landen GC. Calhoun J. Antimicrobial treatment of osteomyelitis. Clin Orthop. 1993; 295:87-95.","DOI":"10.1097\/00003086-199310000-00013"},{"key":"e_1_3_1_31_1","doi-asserted-by":"crossref","unstructured":"30. Wininger DA Pass RJ. Antibiotic-impregnated cement and beads for orthopedic infections. Antimicrob Agents Chemother. 1996: 40:2675-2679.","DOI":"10.1128\/AAC.40.12.2675"},{"key":"e_1_3_1_32_1","doi-asserted-by":"crossref","unstructured":"31. Calhoun JH Mader JT. Antibiotic beads in the management of surgical infections. Am J Surg. 1989; 157:443-449.","DOI":"10.1016\/0002-9610(89)90597-7"},{"key":"e_1_3_1_33_1","doi-asserted-by":"crossref","unstructured":"32. Hedstrom SA. Lidgren L Torholm C. Onnerfalt R. Antibiotic containing bone cement beads in the treatment of deep muscle and skeletal infections. Acta Orthop Scand. 1 980; 51:863-869.","DOI":"10.3109\/17453678008990886"},{"key":"e_1_3_1_34_1","doi-asserted-by":"crossref","unstructured":"33. Ostermann PA Seligson D Henry SL. Local antibiotic therapy for severe open fractures. A review of 1085 consecutive cases. J Bone Joint Surg Br. 1995; 77:93-97.","DOI":"10.1302\/0301-620X.77B1.7822405"},{"key":"e_1_3_1_35_1","unstructured":"34. Ballard TW Snyder MA. Antibiotic prophylaxis in total joint arthroplasty: a review of the literature. Contemporary Orthopaedics. 1989; 18:585-591."},{"key":"e_1_3_1_36_1","doi-asserted-by":"crossref","unstructured":"35. Trippel SB. Antibiotic-impregnated cement in total joint arthroplasty. J Bone Joint Surg Am. 1986:68:1297-1302.","DOI":"10.2106\/00004623-198668080-00026"},{"key":"e_1_3_1_37_1","doi-asserted-by":"crossref","unstructured":"36. Duncan CP Beauchamp C. A temporary antibiotic-loaded joint replacement system for management of complex infections involving the hip. Orthop Clin North Am. 1993: 24:751-759.","DOI":"10.1016\/S0030-5898(20)31855-1"},{"key":"e_1_3_1_38_1","doi-asserted-by":"crossref","unstructured":"37. Elson RA. Exchange arthroplasty for infection. Perspectives from the United Kingdom. Orthop Clin North Am. 1993; 24:761-767.","DOI":"10.1016\/S0030-5898(20)31856-3"},{"key":"e_1_3_1_39_1","doi-asserted-by":"crossref","unstructured":"38. Oxborrow NJ Stamer J Andrews M Stone MH. New uses for gen tamia n-impregnuted polymethyl methacrylate spacers in twostage revision hip arthroplasty. J Arthroplasty. 1997; 12:709-710.","DOI":"10.1016\/S0883-5403(97)90147-9"},{"key":"e_1_3_1_40_1","doi-asserted-by":"crossref","unstructured":"39. Ure KJ. Amstutz HC Nasser S. Schmalzried TP. Direct-exchange arthroplasty for the treatment of infection after total hip replacement. An average 10-year follow-up. J Bone Joint Surg Arn. 1998:80:961-968.","DOI":"10.2106\/00004623-199807000-00004"},{"key":"e_1_3_1_41_1","doi-asserted-by":"crossref","unstructured":"40. Havelin LI Engesaeter LB. Espehaug B Furnes O Lie SA Vollset SE. The Norwegian Arthroplasty Register: 1 1 years and 73 000 anhroplasties. Acia Orthop Scand 2000:71:337-353.","DOI":"10.1080\/000164700317393321"},{"key":"e_1_3_1_42_1","unstructured":"41. Best AJ. Fender D. Harper WM McCaskie AW Oliver K Gregg PJ. Current practice in primary total hip replacement: results from the National Hip Replacement Outcome Project. Ann K Coll Surf; Engl. 1998; 80:350355."},{"key":"e_1_3_1_43_1","doi-asserted-by":"crossref","unstructured":"42. Bourne RB. Antibiotic bone cement approval: fuss-in at the Feds! Orthopedics. 2002; 25:913-914.","DOI":"10.3928\/0147-7447-20020901-11"},{"key":"e_1_3_1_44_1","doi-asserted-by":"crossref","unstructured":"43. Fish DN Hoffman HM DanzigerLH. Antibiotic-impregnated cement use in US hospitals. Am J Hosp Pharm. 1992; 49:2469-2474.","DOI":"10.1093\/ajhp\/49.10.2469"},{"key":"e_1_3_1_45_1","doi-asserted-by":"crossref","unstructured":"44. Heck D Rosenberg A Schink-Ascani M Garbus S. Kiewitt T. Use of antibiotic-impregnated cement during hip and knee arthroplasty in the United States. J Arthroplasty. 1995; 10:470-175.","DOI":"10.1016\/S0883-5403(05)80148-2"},{"key":"e_1_3_1_46_1","doi-asserted-by":"crossref","unstructured":"45. Nelson CL Griffin FM. Harrison BH Cooper RE. In vitro elution characteristics of commercially and noncommercially prepared antibiotic PMMA beads. Clin Orthop 1992; 284:303-309.","DOI":"10.1097\/00003086-199211000-00042"},{"key":"e_1_3_1_47_1","unstructured":"46. How to read clinical journals I: why to read them and how to start reading them critically. Can Med Assoc J. 1981; 124:555-558."},{"key":"e_1_3_1_48_1","doi-asserted-by":"crossref","unstructured":"47. Oxman AD Sackett DL Guyatt GH. Users' guides to the medical literature I: how to get started The Evidence-Based Medicine Working Group. JAMA. 1993: 270:2093-2095.","DOI":"10.1001\/jama.270.17.2093"},{"key":"e_1_3_1_49_1","doi-asserted-by":"crossref","unstructured":"48. Oxman AD. Cook DJ Guyatt GH. Users' guides to the medical literature. VI: how to use an overview. Evidence-Based Medicine Working Group. JAMA. 1994; 272:13671371.","DOI":"10.1001\/jama.1994.03520170077040"},{"key":"e_1_3_1_50_1","unstructured":"49. Buchholz HW Engelbrecht H. Depot effects of various antibiotics mixed with Palacos resins. Chirurg. 1970:41:511-515."},{"key":"e_1_3_1_51_1","unstructured":"50. Buchholz HW Ganmann HD. Infection prevention and surgical management of deep insidious infection in total endoprosthesis. Chirurg. 1972:43:446-453."},{"key":"e_1_3_1_52_1","unstructured":"51. Biichholz HW Engelbrecht E. Rottger J Siegel A. Findings after the replacement of more than 400 infected hip joint endoprostheses. Orthop\u00e4dische Praxis. 1977: 12:1117-1120."},{"key":"e_1_3_1_53_1","unstructured":"52. Pfarr B. Burri C. Prospective study on the effect of gentamycin-Palacos in 200 total hip prostheses. Aktuelle Probi Chir Orthop. 1979; 12:207-210."},{"key":"e_1_3_1_54_1","unstructured":"53. Rottger J. Buchholz HW. Engelbrecht E Siegel A. Gentamycin-PMMA in joint prosthesis. Indication and tcchnic in the use of Refobacin-Palacos in joint prostfiesis. Aktuelle Probi Chir Orthop. 1979: 12:197-200."},{"key":"e_1_3_1_55_1","unstructured":"54. Thierse L. Experiences with Refobacin-Palacos with regard to deep late infections following hip-joint endoprosthesis surgery. A 4years' study. 7. Orthop Ihre Greiiyeb. 1978: 116:847-852."},{"key":"e_1_3_1_56_1","unstructured":"55. Wannske M Tscheme H. Results of prophylactic use of Refobac in- Palacos in implantation of endoprostheses of the hip joint in Hannover. Aktuelle PmM Chir Orthop. 1 979; 12:201-205."},{"key":"e_1_3_1_57_1","doi-asserted-by":"crossref","unstructured":"56. Jadad AR. Moore RA Carroll D. el al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Cimimi Clin Trials. 1996; 17:1-12.","DOI":"10.1016\/0197-2456(95)00134-4"},{"key":"e_1_3_1_58_1","doi-asserted-by":"crossref","unstructured":"57. Harris RP Helfend M Woolf SH. et al. Current methods of die US Preventive Services Task Force. A review of the process. Am J Prev Med. 2001:20:21-35.","DOI":"10.1016\/S0749-3797(01)00261-6"},{"key":"e_1_3_1_59_1","doi-asserted-by":"crossref","unstructured":"58. Benson K Hartz AJ. A comparison of observational studies and randomized controlled trials. N Engl J Med. 2000; 342: 1878-1886.","DOI":"10.1056\/NEJM200006223422506"},{"key":"e_1_3_1_60_1","doi-asserted-by":"crossref","unstructured":"59. Concato J. Shah N. Horwitz RI. Randomized controlled trials observational studies and the hierarchy of research designs. N Engl J Med. 2000; 342: 1887- 1892.","DOI":"10.1056\/NEJM200006223422507"},{"key":"e_1_3_1_61_1","doi-asserted-by":"crossref","unstructured":"60. Feinstem AR Horwitz Rl. Problems in the \"evidence\" of \"evidence-based medicine.\" Am J Med. 1997; 103:529-535.","DOI":"10.1016\/S0002-9343(97)00244-1"},{"key":"e_1_3_1_62_1","doi-asserted-by":"crossref","unstructured":"61. Hornberger J Wrone E. When lo base clinical policies on observational versus randomized trial data. Ann Intern Med. 1997; 127:697703.","DOI":"10.7326\/0003-4819-127-8_Part_2-199710151-00053"},{"key":"e_1_3_1_63_1","doi-asserted-by":"crossref","unstructured":"62. Moore B. Antibiotics in cement. J Bone Joint Surg Br. 1977:59:139-142.","DOI":"10.1302\/0301-620X.59B2.873973"},{"key":"e_1_3_1_64_1","doi-asserted-by":"crossref","unstructured":"63. Norden CW. A critical review of antibiotic prophylaxis in orthopedic surgery. Rev Infect Dis. 1983:5:928-932.","DOI":"10.1093\/clinids\/5.5.928"},{"key":"e_1_3_1_65_1","doi-asserted-by":"crossref","unstructured":"64. Norden CW. Prevention of bone and joint infections. Am J Med. 1985:78:229-232.","DOI":"10.1016\/0002-9343(85)90390-0"},{"key":"e_1_3_1_66_1","doi-asserted-by":"crossref","unstructured":"65. Danziger LH. Controversies in antimicrobial therapy: innovative methods of administration. Am J Hosp Pharm. 1986;43:646-652.","DOI":"10.1093\/ajhp\/43.3.646"},{"key":"e_1_3_1_67_1","doi-asserted-by":"crossref","unstructured":"66. Norden CW. Antibiotic prophylaxis in orthopedic surgery. Rev Infect Dis. 1991: 13(suppl 10): S842-S846.","DOI":"10.1093\/clinids\/13.Supplement_10.S842"},{"key":"e_1_3_1_68_1","doi-asserted-by":"crossref","unstructured":"67. Josefsson G. Lindberg L Wiklander B. Systemic antibiotics and gentamiein-conlaining bone cement in the prophylaxis of postoperative infections in total hip arthroplasly. Clin Orthop. 1981:159:194-200.","DOI":"10.1097\/00003086-198109000-00027"},{"key":"e_1_3_1_69_1","doi-asserted-by":"crossref","unstructured":"68. Josefsson G Gudmundsson G Kolmcrl L Wijkstrom S. Prophylaxis with systemic antibiotics versus gentamicin bone cement in total hip arthroplasly. A 5-year survey of 1688 hips. Clin Orthop. 1990;253:173-178.","DOI":"10.1097\/00003086-199004000-00023"},{"key":"e_1_3_1_70_1","doi-asserted-by":"crossref","unstructured":"69. Josefsson G. Kolmert L. Prophylaxis with systematic antibiotics versus gentamicin bone cement in total hip arthroplasty. A 10-year survey of 1688 hips. Clin Orthop. 1993; 292:210-214.","DOI":"10.1097\/00003086-199307000-00026"},{"key":"e_1_3_1_71_1","doi-asserted-by":"crossref","unstructured":"70. McQueen M. Linlejohn A. Hughes SR A comparison of systemic cefuroxime and cefuroxime loaded bone cement in the prevention of early infection after total joint replacement. Int Orthop. 1987:11:241-243.","DOI":"10.1007\/BF00271455"},{"key":"e_1_3_1_72_1","doi-asserted-by":"crossref","unstructured":"71. McQueen MM. Hughes SP May P Verity L. Cefuroxime in total joint arthroplasty. Intravenous or in bone cement. J Arthmplasrv. 1990: 5:169-172.","DOI":"10.1016\/S0883-5403(06)80236-6"},{"key":"e_1_3_1_73_1","doi-asserted-by":"crossref","unstructured":"72. Chin FY. Lin CF Chen CM. Lo WH. Chaung TY. Cefuroxime-i impregnated cement at primary total knee arthroplasly in diabetes mellinis. A prospective randomised study. 7 Hone Joint Surg Br. 2001:83:691-695.","DOI":"10.1302\/0301-620X.83B5.0830691"},{"key":"e_1_3_1_74_1","doi-asserted-by":"crossref","unstructured":"73. Chiu FY. Chen CM. Lin CF. Lo WH. Cefuroxime-impregnaled cement in primary total knee arthroplasty: a prospective randomized study of 340 knees. J Bone Joint Suiy Am. 2002; 84:759-762.","DOI":"10.2106\/00004623-200205000-00009"},{"key":"e_1_3_1_75_1","doi-asserted-by":"crossref","unstructured":"74. Buchholz HW. Elson RA. Heiner! K. Antibiotic-loaded acrylic cement: current concepts. Clin Orthop. 1984: 190:96-108.","DOI":"10.1097\/00003086-198411000-00014"},{"key":"e_1_3_1_76_1","doi-asserted-by":"crossref","unstructured":"75. Lynch M Esser MP. Shelley P Wroblewski BM. Deep infection in Chamley low-friction arthroplasty. Comparison of plain and genlamicin-loaded cement. J Bone Joint Surg Br. 1987: 69:355-360.","DOI":"10.1302\/0301-620X.69B3.3584184"},{"key":"e_1_3_1_77_1","doi-asserted-by":"crossref","unstructured":"76. Malchau H. Herberts P. Ahnfelt L. Prognosis of total hip replacement in Sweden. Follow-up of 92 675 operations performed 1978-1990. Aria Orthop Scand. 1993; 64:497-506.","DOI":"10.3109\/17453679308993679"},{"key":"e_1_3_1_78_1","doi-asserted-by":"crossref","unstructured":"77. Havelin Ll. Espehaug B. Vollset SE. Engesaeter LB. The effect of the type of cement on early revision of Chamley total hip proslhescs. A review of 8579 primary arthroplasties from the Norwegian Arthroplasty Resister. J Bone Joint Surg Am. 1995;77:1543-1550.","DOI":"10.2106\/00004623-199510000-00009"},{"key":"e_1_3_1_79_1","doi-asserted-by":"crossref","unstructured":"78. Espehaug B Engesaeter LB Vollset SE Havelin LI Langeland N. Antibiotic prophylaxis in total hip anhroplasty. Review of 10 905 primary cemented total hip replacements reported to the Norwegian arthroplasty register. 1987 to 1995. J Bone Join! Si\/?? Br. 1 997; 79:590-595.","DOI":"10.1302\/0301-620X.79B4.0790590"},{"key":"e_1_3_1_80_1","doi-asserted-by":"crossref","unstructured":"79. Persson U Persson M. Malchau H. The economics of preventing revisions in total hip replacement. Acta Orthop Scand. 1999; 70:163169.","DOI":"10.3109\/17453679909011256"},{"key":"e_1_3_1_81_1","doi-asserted-by":"crossref","unstructured":"80. Espehaug B Havelin Ll. Engesaeter LB Langeland N Vollset SE. Patient-related risk factors for early revision of total hip replacements. A population register-based case-control study of 674 revised hips. Acia Orthop Scant!. 1 997; 68:207-215.","DOI":"10.3109\/17453679708996686"},{"key":"e_1_3_1_82_1","doi-asserted-by":"crossref","unstructured":"81. Murray WR. Use of antibiotic -containing bone cement. Clin Orthop. 1984: 190:89-95.","DOI":"10.1097\/00003086-198411000-00013"},{"key":"e_1_3_1_83_1","doi-asserted-by":"crossref","unstructured":"82. Chamley J. Eftekhar N. Postoperative infection in total prosthetic replacement arthroplasty of the hip-joint. With special reference to the bacterial content of the air of the operating room. Br J Surg. 1969:56:641-649.","DOI":"10.1002\/bjs.1800560902"},{"key":"e_1_3_1_84_1","doi-asserted-by":"crossref","unstructured":"83. Chamley J. Postoperative infection after total hip replacement with special reference to air contamination in die operating room. Clin Orthop. 1972:87:167-187.","DOI":"10.1097\/00003086-197209000-00020"},{"key":"e_1_3_1_85_1","doi-asserted-by":"crossref","unstructured":"84. Lidwell OM. Lowbury FJ. Whyte W Blowers R. Stanley SJ. Lowc D. Ventilation in operating rooms. Br Med J (Clin Res Ed). 1983; 286:1214-1215.","DOI":"10.1136\/bmj.286.6372.1214-a"},{"key":"e_1_3_1_86_1","doi-asserted-by":"crossref","unstructured":"85. Fitzgerald RH Jr. Bechtol CO. Eftekhar N. Nelson JP. Reduction of deep sepsis after total hip arthroplasty. Arch Surg. 1979: 114:803-804.","DOI":"10.1001\/archsurg.1979.01370310045009"},{"key":"e_1_3_1_87_1","doi-asserted-by":"crossref","unstructured":"86. Lidwell OM. Clean air at operation and subsequent sepsis in the joint. CHn Orthop. 1986; 211:91-102.","DOI":"10.1097\/00003086-198610000-00013"},{"key":"e_1_3_1_88_1","doi-asserted-by":"crossref","unstructured":"87. Salvati EA. Robinson RP. Zeno SM Koslin BL. Brause BD Wilson PD Jr. Infection rates after 3175 total hip and total knee replacements performed with and without a horizontal unidirectional filtered air-How system. J Bone Joint Surg Am. 1982:64:525-535.","DOI":"10.2106\/00004623-198264040-00007"},{"key":"e_1_3_1_89_1","doi-asserted-by":"crossref","unstructured":"88. Espehaug B Fumes O. Havelin LI. Engesaeter LB. Vollset SE. The type of cement and failure of total hip replacements. J Bout' Joint Surg Br. 2002: 84:832-838.","DOI":"10.1302\/0301-620X.84B6.0840832"},{"key":"e_1_3_1_90_1","doi-asserted-by":"crossref","unstructured":"89. Hope PG Kristinsson KG. Norman P. Elson RA. Deep infection of cemented total hip arlhroplaslies caused by coagulase-negalivc slaphylococci. J Bone Joint Siirg Br. 1989; 71:851-855.","DOI":"10.1302\/0301-620X.71B5.2584258"},{"key":"e_1_3_1_91_1","doi-asserted-by":"crossref","unstructured":"90. Hunter GA Welsh RP. Cameron HU. Bailey WH. The results of revision of total hip arthroplasty. J Rone Joint Surf; Br. 1979: 61:419421.","DOI":"10.1302\/0301-620X.61B4.500750"},{"key":"e_1_3_1_92_1","doi-asserted-by":"crossref","unstructured":"91. Tunney MM. Patrick S. Gorman SP. et al. Improved detection of infection in hip replacements. A currently underestimated problem. J Bone Joint Surg Br. 1998; 80:568-572.","DOI":"10.1302\/0301-620X.80B4.0800568"},{"key":"e_1_3_1_93_1","doi-asserted-by":"crossref","unstructured":"92. Mudoitw EQ. Juditon S. Pulerrak H Law infections of total joint prostheses. A review and recommendations for prevention. Clip Orthop. 1988; 229:131-142.","DOI":"10.1097\/00003086-198804000-00017"},{"key":"e_1_3_1_94_1","doi-asserted-by":"crossref","unstructured":"93. Bniuse BD. Infections associated with prosthetic joints. Clin Rheum Dir. 1986: 12:523-536.","DOI":"10.1016\/S0307-742X(21)00563-4"},{"key":"e_1_3_1_95_1","unstructured":"94. Brause B. Infected orthopedic prostheses. In: Bisno AL Waidvogel FA. ads. lnfrcrions Associated With Indwelling Medical Devices. Washington DC: American Society for Microbiology; 1989:111-127."},{"key":"e_1_3_1_96_1","doi-asserted-by":"crossref","unstructured":"95. Simon R. Wittes RE. Methodologic guidelines for reports of clinical trials. Cancer Treat Rep. 1985: 69:1-3.","DOI":"10.1002\/1097-0142(19860701)58:1<212::AID-CNCR2820580135>3.0.CO;2-Z"},{"key":"e_1_3_1_97_1","doi-asserted-by":"crossref","unstructured":"96. Brien WW. Salvati EA Klein R Brause B. Stem S. Antibiotic impregnated bone cement in total hip arthropla.sty. An in vivo comparison of the elution properties of tobramycin and vancomycin. Clin Orthop. 1993:296:242-248.","DOI":"10.1097\/00003086-199311000-00040"},{"key":"e_1_3_1_98_1","doi-asserted-by":"crossref","unstructured":"97. Della Valle AG Bostmm M. Brause B. Harney C Salvati EA. Effective bactericidal activity of tobramycin and vancomycin eluted from acrylic bone cement. Acta Orthop Stand. 2001: 72:237-240.","DOI":"10.1080\/00016470152846547"},{"key":"e_1_3_1_99_1","doi-asserted-by":"crossref","unstructured":"98. Eckman lB Jr. Uenry SL Mangino PD Setigson D. Wound and serum levels of tobramycin with the prophylactic use of tohramycinimpregnated polymethylmethacrylate beads in compound fractures. Clin Onthop. 1988: 237:213-215.","DOI":"10.1097\/00003086-198812000-00031"},{"key":"e_1_3_1_100_1","doi-asserted-by":"crossref","unstructured":"99. Henry SL. Galloway KR Local antibacterial therapy for the management of orthopaedic infections. Phamiacokinetic considerations. Chit Pharinacokinet. 1995; 29:36-45.","DOI":"10.2165\/00003088-199529010-00005"},{"key":"e_1_3_1_101_1","doi-asserted-by":"crossref","unstructured":"100. Klekamp I. Dawson JM Fiaas DW DeBoer D. Christie M. The use of vancomycin and tobramycin in acrylic bone cement: biomec hanical effects and elution kinetics for use in joint arthroplasty. J Arthrosplasty. 1999; 14:339-346.","DOI":"10.1016\/S0883-5403(99)90061-X"},{"key":"e_1_3_1_102_1","doi-asserted-by":"crossref","unstructured":"101. Masni BA Duncan CP. Beauchamp CP. Longtenli elution of antibiotics from bone-cement: an in vivo study using the prosthesis of antibiotic-loaded acrylic cement (PROSTALAC) systent JArthmplastv. 1998; 13:331-338.","DOI":"10.1016\/S0883-5403(98)90179-6"},{"key":"e_1_3_1_103_1","doi-asserted-by":"crossref","unstructured":"102. Tohias KM. Schneider RK. Besser TE. Use of antimicrobial-impregnated polyniethyl methacrylate. J Am Vet Med Assoc. 1996: 208:841845.","DOI":"10.2460\/javma.1996.208.06.841"},{"key":"e_1_3_1_104_1","doi-asserted-by":"crossref","unstructured":"103. Blaha ID. Calhoun il-I. Nelson CL. ci a!. Comparison of the clinical efficacy and tolerance of gentamicin PMMA beads on surgical wire versus combined and systemic therapy for osteomyelitis. Clin Orthrtp. 1993; 295:8-12.","DOI":"10.1097\/00003086-199310000-00003"},{"key":"e_1_3_1_105_1","doi-asserted-by":"crossref","unstructured":"104. van de Belt H. Neut I). Schenk W. van Horn JR. van der Mei UC. Busscher HI. Inketion of orthopedic implants and the use of antibioticloaded bone cements. A review. 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