{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T22:12:24Z","timestamp":1773180744637,"version":"3.50.1"},"reference-count":0,"publisher":"SLACK, Inc.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthopedics"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:p>Synovial sarcomas comprise between 5% to 10% of all soft tissue sarcomas in adults and have been reported to be one of the more frequently misdiagnosed sarcomas. It has a unique metastatic pattern and, unlike many other sarcomas, metastasizes to the lymph nodes, other soft tissues, and bone. Cranial metastasis is rare and has only been described in two prior reports. Reports of other sarcomas having intracranial metastasis include rhabdomyosarcoma, angiosarcoma, fibrosarcoma, liposarcoma, Ewing's sarcoma, and clear cell sarcoma from the kidney.<\/jats:p>\n          <jats:p>The synchronous or metachronous development of two or more primary soft tissue sarcomas has been reported. These are primary lesions occurring at multiple soft tissue sites without pulmonary or lymphatic involvement. It is often difficult to distinguish between the synchronous or metachronous appearance of a second primary and STS metastasis. Regional lymph node involvement has been reported in 3% to 10% of patients, and some have suggested performing sentinel lymph node biopsy to assist in staging. Several cases of head and neck metastasis are reported in the literature; however brain metastasis is exceptionally rare. External beam radiation was used palliatively to treat his intracranial lesion; however the patient eventually died from his disease. Synovial sarcoma remains a challenge, both diagnostically and therapeutically. Future therapeutic developments will focus on molecular targets, including the inhibition of angiogenesis. This article presents an unusual case of young adult male with intracranial metastasis from synovial sarcoma involving the buttock.<\/jats:p>","DOI":"10.3928\/01477447-20080401-33","type":"journal-article","created":{"date-parts":[[2009,3,12]],"date-time":"2009-03-12T21:38:28Z","timestamp":1236893908000},"page":"405-405","source":"Crossref","is-referenced-by-count":5,"title":["Intracranial Metastasis From Synovial Sarcoma"],"prefix":"10.3928","volume":"31","author":[{"given":"Herrick J.","family":"Siegel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William H.","family":"Dunham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Lopez-Ben","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gene P.","family":"Siegal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2308","container-title":["Orthopedics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.healio.com\/doiresolver?doi=10.3928\/01477447-20080401-33","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T14:43:56Z","timestamp":1751467436000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.healio.com\/doi\/10.3928\/01477447-20080401-33"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["10.3928\/01477447-20080401-33"],"URL":"https:\/\/doi.org\/10.3928\/01477447-20080401-33","relation":{},"ISSN":["0147-7447","1938-2367"],"issn-type":[{"value":"0147-7447","type":"print"},{"value":"1938-2367","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4]]}}}