{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T14:45:10Z","timestamp":1754145910506,"version":"3.41.2"},"reference-count":11,"publisher":"SLACK, Inc.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthopedics"],"published-print":{"date-parts":[[2009,1]]},"abstract":"\n Colonization of wounds with multidrug-resistant organisms is a difficult orthopedic problem.\n Acinetobacter<\/jats:italic>\n infections are especially difficult because they are resistant to all currently available antibiotics. We present the use of a novel skin sanitizer, Stay Byotrol Clean (Byotrol Inc, Spartanburg, South Carolina), to treat a multidrug-resistant wound infection.\n <\/jats:p>\n \n A 31-year-old T10 paraplegic man presented with chronic bilateral stage IV decubitus trochanteric ulcers. Cultures grew methicillin-resistant\n Staphylococcus aureus<\/jats:italic>\n and vancomycin-resistant\n Enterococcus<\/jats:italic>\n . The ulcers were initially treated with irrigation and debridement and vancomycin, levaquin, and cefepime. After 4 months of aggressive treatment, the cultures continued to be positive for\n Escherichia coli<\/jats:italic>\n and\n Acinetobacter baumannii<\/jats:italic>\n . The patient was started on amikacin and tigecycline. Despite 1 additional month of aggressive wound care, debridements, and intravenous antibiotics, the cultures continued to grow\n A baumannii<\/jats:italic>\n and\n Pseudomonas aerug<\/jats:italic>\n . The\n A baumannii<\/jats:italic>\n was resistant to all available antibiotics tested. The ulcers were then treated with daily application of Stay Byotrol Clean hand and skin sanitizer. Four days later, cultures were negative for any bacterial growth, with no\n A baumannii<\/jats:italic>\n . After 1 week, the ulcers showed new granulation tissue with no visible necrotic tissue. After 3 months of treatment, the ulcers had healed.\n <\/jats:p>\n Stay Byotrol Clean is nonirritating and contains no iodine or alcohol. It is currently being used for decolonization of patients on admission to the hospital, however, there is great potential for its use in wound treatment, preoperative surgical sterilization, and orthopedic devices.<\/jats:p>","DOI":"10.3928\/01477447-20090101-04","type":"journal-article","created":{"date-parts":[[2009,3,16]],"date-time":"2009-03-16T11:41:09Z","timestamp":1237203669000},"page":"58-3","source":"Crossref","is-referenced-by-count":1,"title":["Novel Use of Antimicrobial Hand Sanitizer in Treatment of Nosocomial\n Acinetobacter<\/i>\n Infection"],"prefix":"10.3928","volume":"32","author":[{"given":"Meghan","family":"Donahue","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luke R.","family":"Watson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Torress-Cook","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A.","family":"Watson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2308","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0691.2002.00487.x"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/500202"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.29.2.277-282.1991"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/502302"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1067\/mic.2002.122648"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2004.00942.x"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1301.060716"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2003.07.005"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005131-199702000-00010"},{"key":"e_1_3_1_11_2","first-page":"255","article-title":"Benzalkonium chloride. A potential disinfecting irrigation solution for orthopaedic wounds","volume":"346","author":"Tarbox BB","year":"1998","unstructured":"Tarbox BB, Conroy BP, Malicky ES, . Benzalkonium chloride. A potential disinfecting irrigation solution for orthopaedic wounds. Clin Orthop Relat Res. 1998; (346):255\u2013261.","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005131-199906000-00002"}],"container-title":["Orthopedics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.healio.com\/doiresolver?doi=10.3928\/01477447-20090101-04","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T17:41:24Z","timestamp":1752774084000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.healio.com\/doi\/10.3928\/01477447-20090101-04"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["10.3928\/01477447-20090101-04"],"URL":"https:\/\/doi.org\/10.3928\/01477447-20090101-04","relation":{},"ISSN":["0147-7447","1938-2367"],"issn-type":[{"type":"print","value":"0147-7447"},{"type":"electronic","value":"1938-2367"}],"subject":[],"published":{"date-parts":[[2009,1]]}}}