{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T03:17:55Z","timestamp":1781925475667,"version":"3.54.5"},"reference-count":12,"publisher":"SLACK, Inc.","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthopedics"],"published-print":{"date-parts":[[2010,10,11]]},"abstract":"<jats:p>\n            Lemierre\u2019s syndrome is a severe complication of\n            <jats:italic>Fusobacterium necrophorum<\/jats:italic>\n            oropharyngeal infection associated with metastatic foci of infection, internal jugular vein thrombosis, and septicemia. Musculoskeletal manifestations include isolated or multifocal septic arthritis, soft tissue abscesses, pyomyositis, and osteomyelitis.\n          <\/jats:p>\n          <jats:p>\n            This article describes a case of a variant of Lemierre\u2019s syndrome in a 17-year-old girl, demonstrating a relentless case of limb infection refractory to multiple surgical debridements and broad-spectrum and targeted antibiotics. The patient had\n            <jats:italic>F necrophorum<\/jats:italic>\n            within a peritonsillar abscess and multiple foci within her right lower extremity. Overall, she required 12 surgical procedures and 14 weeks of antibiotic therapy to resolve the infection. Further unique findings in this case include the presence of a recent lateral meniscus tear with associated hemarthrosis treated with a short course of oral steroids prior to the diagnosis of septic arthritis. Knee arthroscopy with lysis of adhesions and manipulation at 6 months postinfection demonstrated significant chondral damage. Outcome at &gt;2-year follow-up revealed pain-free activities of daily living and the ability to return to competitive, club-level collegiate softball.\n          <\/jats:p>\n          <jats:p>\n            Clinically relevant findings illustrated in this case include potential development of antibiotic resistance within\n            <jats:italic>Fusobacterium<\/jats:italic>\n            genus with little to no response to several surgical debridements and broad-spectrum and targeted antibiotics, and development of multifocal, ipsilateral septic arthritis and soft tissue abscesses and pyomyositis in the context of steroid use and recent intra-articular knee injury.\n          <\/jats:p>","DOI":"10.3928\/01477447-20100826-27","type":"journal-article","created":{"date-parts":[[2010,10,18]],"date-time":"2010-10-18T20:10:47Z","timestamp":1287432647000},"source":"Crossref","is-referenced-by-count":7,"title":["Severe Musculoskeletal Infection Variant in Lemierre\u2019s Syndrome"],"prefix":"10.3928","volume":"33","author":[{"given":"Joshua D.","family":"Harris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C.","family":"Kaeding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Flanigan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Naylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2308","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199072080-00020"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000091374.54304.7c"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)57035-4"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004310050730"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20542"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.7.3369-3370.2004"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000178295.48885.fa"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198903000-00002"},{"key":"e_1_3_1_10_2","volume-title":"Topley and Wilson\u2019s Principles of Bacteriology, Virology, and Immunology","author":"Duerden B","year":"1984","unstructured":"Duerden B. Topley and Wilson\u2019s Principles of Bacteriology, Virology, and Immunology. 7th ed. London, England: Edward Arnold; 1984.","edition":"7"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.15.4.527-544.2002"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453678909150107"},{"issue":"1","key":"e_1_3_1_13_2","first-page":"44","article-title":"Ultrastructure of articular cartilage in pyogenic arthritis","volume":"99","author":"Roy S","year":"1975","unstructured":"Roy S, Bhawan J. Ultrastructure of articular cartilage in pyogenic arthritis. Arch Pathol. 1975; 99(1):44\u201347.","journal-title":"Arch Pathol"}],"container-title":["Orthopedics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.healio.com\/orthopedics\/infection\/journals\/ortho\/2010-10-33-10\/%7B9e0cca2e-f033-4dcd-86b6-e9353c0d56ad%7D\/severe-musculoskeletal-infection-variant-in-lemierres-syndrome","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T15:07:21Z","timestamp":1683040041000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.healio.com\/doi\/10.3928\/01477447-20100826-27"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,11]]},"references-count":12,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010,10,11]]}},"alternative-id":["10.3928\/01477447-20100826-27"],"URL":"https:\/\/doi.org\/10.3928\/01477447-20100826-27","relation":{},"ISSN":["0147-7447","1938-2367"],"issn-type":[{"value":"0147-7447","type":"print"},{"value":"1938-2367","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,11]]},"article-number":"01477447-20100826-27"}}