{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T18:18:40Z","timestamp":1793729920347,"version":"4.6.1"},"reference-count":14,"publisher":"SLACK, Inc.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthopedics"],"published-print":{"date-parts":[[2011,1,3]]},"abstract":"<jats:p>Bacille Calmette-Gu\u00e9rin osteomyelitis in infants is a known complication of Bacille Calmette-Gu\u00e9rin vaccination. Treatment consists of antituberculosis chemotherapy after biopsy\/curettage; however, in cases of Bacille Calmette-Gu\u00e9rin osteomyelitis extending to the growth plate and epiphysis, the extent and time of surgical treatment such as curettage\/biopsy is unknown because of bone growth disturbances. This article presents a case of an infant with this type of Bacille Calmette-Gu\u00e9rin osteomyelitis at the proximal tibia. A metaanalytic review was performed for possible risk factors of its recurrence. In our patient, primary curettage of partial lesion, excluding the part extending to the growth plate and epiphysis, failed, and recurettage of the extended lesion involving the growth plate and epiphysis was required for its eradication, resulting in bone growth disturbance. In the metaanalysis, 7 literatures reporting 14 cases of Bacille Calmette-Gu\u00e9rin osteomyelitis extending to the growth plate and epiphysis were included. Although statistical analysis showed no significant risk factors associated with the recurrence, these cases showed high recurrence rate in approximately 55.6%, requiring reoperation. Generally, the smaller damage to the growth plate can minimize bone growth disturbance. Taken together, it is suggested that Bacille Calmette-Gu\u00e9rin osteomyelitis extending to the growth plate and epiphysis is associated with high recurrence rate, and early curettage of the entire lesion should be performed to eradicate it and avoid resulting complications.<\/jats:p>","DOI":"10.3928\/01477447-20101123-24","type":"journal-article","created":{"date-parts":[[2011,1,6]],"date-time":"2011-01-06T14:18:05Z","timestamp":1294323485000},"source":"Crossref","is-referenced-by-count":11,"title":["Surgical Treatment of an Infant with Bacille Calmette-Gu\u00e9rin Osteomyelitis Extending Across the Growth Plate"],"prefix":"10.3928","volume":"34","author":[{"given":"Daichi","family":"Ishimaru","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyasu","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuji","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2308","reference":[{"issue":"2","key":"e_1_3_1_2_2","first-page":"169","article-title":"Osteomyelitis as a late complication of Bacille Calmette-Gu\u00e9rin vaccination","volume":"39","author":"Khotaei GT","year":"2006","unstructured":"Khotaei GT, Sedighipour L, Fattahi F, et al. Osteomyelitis as a late complication of Bacille Calmette-Gu\u00e9rin vaccination. J Microbiol Immunol Infect. 2006; 39(2):169\u2013172.","journal-title":"J Microbiol Immunol Infect"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.4065\/77.4.393"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.59.2.157"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199909000-00012"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.58B2.1084349"},{"issue":"3","key":"e_1_3_1_7_2","first-page":"125","article-title":"Antibiotic-loaded porous hydroxyapatite blocks for the treatment of osteomyelitis and postoperative infection: A preliminary report","volume":"57","author":"Itokazu M","year":"1998","unstructured":"Itokazu M, Aoki T, Nonomura H, et al. Antibiotic-loaded porous hydroxyapatite blocks for the treatment of osteomyelitis and postoperative infection: A preliminary report. 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