{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T13:14:56Z","timestamp":1683119696328},"reference-count":14,"publisher":"SLACK, Inc.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthopedics"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p>The purpose of this study was to elaborate on the association between the use of bisphosphonates and low-energy femoral shaft fractures. A retrospective review was performed between January 2000 and January 2010 to identify patients older than 65 years who sustained femoral shaft diaphyseal fractures (Orthopaedic Trauma Association classification 32 A [extra-articular], B [partial articular\/unicondylar], or C [complete articular\/bicondylar]) using ICD-9 code 821.01. After exclusion criteria were applied, 77 patients remained for analysis. A total of 66 patients had no history of bisphosphonate therapy, and 11 patients had received bisphosphonate therapy for &gt;2 years prior to admission. All 11 patients in the bisphosphonate group had sustained a low-energy fall from a standing height or lower. In 9 of 11 (82%) patients in the bisphosphonate group, radiographs resembled transverse shaft fractures with lateral cortical beaking that have been observed in patients on chronic bisphosphonate therapy.<\/jats:p>\n          <jats:p>Our series echoes the findings of other authors, who found that bisphosphonate use is associated with lateral cortical beaking and low-energy, transverse fractures of the femoral shaft. Further research is needed to determine if specific medications and length of treatment are important risk factors.<\/jats:p>","DOI":"10.3928\/01477447-20111122-06","type":"journal-article","created":{"date-parts":[[2012,1,9]],"date-time":"2012-01-09T20:28:48Z","timestamp":1326140928000},"source":"Crossref","is-referenced-by-count":2,"title":["Association of Low-energy Femoral Shaft Fractures and Bisphosphonate Use"],"prefix":"10.3928","volume":"35","author":[{"given":"John R.","family":"Fowler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew R.","family":"Craig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2308","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200300003-00003"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.D.03032"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjopharm.2009.12.004"},{"issue":"11","key":"e_1_3_1_5_2","first-page":"1426","article-title":"Do bisphosphonates reduce the risk of osteoporotic fractures? An evaluation of the evidence to date","volume":"166","author":"Hodsman AB","year":"2002","unstructured":"Hodsman AB, Hanley DA, Josse R. Do bisphosphonates reduce the risk of osteoporotic fractures? An evaluation of the evidence to date. CMAJ. 2002; 166(11):1426\u20131430.","journal-title":"CMAJ"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)07088-2"},{"issue":"1","key":"e_1_3_1_7_2","first-page":"CD001155","article-title":"Alendronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women","author":"Wells GA","year":"2008","unstructured":"Wells GA, Cranney A, Peterson J, et al. Alendronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women. Cochrane Database Syst Rev. 2008; (1):CD001155.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.H.01774"},{"issue":"6","key":"e_1_3_1_9_2","first-page":"485","article-title":"Sequential non-traumatic femoral shaft fractures in a patient on long-term alendronate","volume":"13","author":"Cheung RK","year":"2007","unstructured":"Cheung RK, Leung KK, Lee KC, Chow TC. Sequential non-traumatic femoral shaft fractures in a patient on long-term alendronate. Hong Kong Med J. 2007; 13(6):485\u2013489.","journal-title":"Hong Kong Med J"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.89B3.18146"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2007.08.036"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0707493"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-008-0805-x"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0b013e318172841c"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-009-0725-x"}],"container-title":["Orthopedics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.slackinc.com\/doi\/resolver.asp?doi=10.3928\/01477447-20111122-06","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T16:21:11Z","timestamp":1683044471000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.healio.com\/doi\/10.3928\/01477447-20111122-06"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["10.3928\/01477447-20111122-06"],"URL":"https:\/\/doi.org\/10.3928\/01477447-20111122-06","relation":{},"ISSN":["0147-7447","1938-2367"],"issn-type":[{"value":"0147-7447","type":"print"},{"value":"1938-2367","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}