{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T23:56:10Z","timestamp":1725494170552},"reference-count":23,"publisher":"SLACK, Inc.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthopedics"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>Spontaneous simultaneous bilateral quadriceps tendon rupture is associated with multiple medical conditions and pharmacological treatments; however, identifying prior risk factors is impossible in most cases. Achilles tendon and anterior cruciate ligament ruptures are associated with collagen, type V, alpha 1 (COL5A1) polymorphism. This genetic variant may be implicated quadriceps tendon rupture. The COL5A1 encodes the protein for pro-\u03b11 chains of the low-abundance heterotrimeric type V collagen. In most noncartilaginous tissues, type V collagen is a quantitatively minor component of type I collagen that has been implicated in the regulation of the size and configuration of type I collagen fibrils. The functional significance of COL5A1 polymorphism in relation to type V collagen expression or activity has not been determined.<\/jats:p>\n          <jats:p>This article describes a patient with COL5A1 polymorphism and spontaneous simultaneous quadriceps tendon rupture. However, genetic and histologic studies performed on blood and tendon tissues and 3 consecutive sex- and age-matched controls showed a statistically significant reduction in collagen type V expression and an alteration in collagen structure in the tendon. These findings might explain the pathomechanisms of spontaneous tendon ruptures associated with COL5A1 polymorphism.<\/jats:p>","DOI":"10.3928\/01477447-20120327-31","type":"journal-article","created":{"date-parts":[[2012,4,11]],"date-time":"2012-04-11T18:56:12Z","timestamp":1334170572000},"source":"Crossref","is-referenced-by-count":7,"title":["Collagen Type V Polymorphism in Spontaneous Quadriceps Tendon Ruptures"],"prefix":"10.3928","volume":"35","author":[{"given":"Olimpio","family":"Galasso","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Iaccino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Gallelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ida","family":"Perrotta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Conforti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Donato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Gasparini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2308","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.66B1.6693484"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-006-0133-7"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005131-199805000-00010"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.77B1.7822381"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/JSM.0b013e31814c3e69"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-200305000-00006"},{"issue":"8","key":"e_1_3_2_8_2","first-page":"867","article-title":"Bilateral spontaneous quadriceps tendon ruptures. 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