{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T02:29:34Z","timestamp":1726453774025},"reference-count":20,"publisher":"SLACK, Inc.","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthopedics"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>\n            Mucormycosis has been reported in otherwise healthy individuals; however, it is primarily seen in immunocompromised patients, such as those with diabetes mellitus, malignancy, or chronic graft-versus-host disease, and has a high mortality rate. Because most cases of mucormycosis are associated with contiguous rhinocerebral infection, only 5 cases of isolated musculoskeletal\n            <jats:italic>Rhizopus<\/jats:italic>\n            infection have been reported in the literature. One patient underwent hematopoietic cell transplant, which resulted in a fatal outcome.\n          <\/jats:p>\n          <jats:p>\n            This article describes the successful treatment of isolated\n            <jats:italic>Rhizopus<\/jats:italic>\n            osteomyelitis in a patient who underwent hematopoietic cell transplant using a combined surgical and medical approach. A 33-year-old woman with pre-B cell acute lymphoblastic leukemia underwent hematopoietic cell transplant with few complications but developed chronic graft-versus-host disease 8 months posttransplant. She was treated with high-dose steroids for 6 weeks before she was admitted for severe right tibial pain in the absence of trauma. Early detection, aggressive therapies, and a multidisciplinary surgical and medical team allowed for the microbiologically confirmed resolution of the infection. Treatment included multiagent antimicrobial therapy with amphotericin B, daptomycin, and ertapenem. Several surgical irrigation and debridement procedures were also performed, with the eventual placement of amphotericin-impregnated polymethylmethacrylate cement beads and small fragment titanium screws. The patient continued taking postoperative antifungal treatment for 7 months after discharge. Six months following the discontinuation of antifungal therapy, the team\u2019s multidisciplinary approach achieved a continued resolution of the patient\u2019s infection and a return to a fully ambulatory and radiographically proven recovery without limb loss.\n          <\/jats:p>","DOI":"10.3928\/01477447-20120919-30","type":"journal-article","created":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T17:40:51Z","timestamp":1349113251000},"source":"Crossref","is-referenced-by-count":11,"title":["Successful Surgical and Medical Treatment of\n            <i>Rhizopus<\/i>\n            Osteomyelitis Following Hematopoietic Cell Transplantation"],"prefix":"10.3928","volume":"35","author":[{"given":"Nikita","family":"Vashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffi","family":"Avedian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally","family":"Arai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2308","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.3983214.x"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.3928\/01477447-20090501-21"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.159.5.1414771"},{"issue":"5","key":"e_1_3_1_5_2","first-page":"383","article-title":"Mucormycosis in the BMT population","volume":"11","author":"Morrison VA","year":"1993","unstructured":"Morrison VA, McGlave PB. Mucormycosis in the BMT population. Bone Marrow Transplant. 1993; 11(5):383\u2013388.","journal-title":"Bone Marrow Transplant"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(79)90505-9"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1148\/127.3.665"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/432579"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.04.007"},{"key":"e_1_3_1_10_2","first-page":"149","volume-title":"Fundamental Techniques of Plastic Surgery","author":"McGregor AD","year":"2000","unstructured":"McGregor AD, McGregor IA. Fundamental Techniques of Plastic Surgery. 10th ed. London, United Kingdom: Churchill Livingstone; 2000:149\u2013150.","edition":"10"},{"key":"e_1_3_1_11_2","first-page":"3257","volume-title":"Principles and Practice of Infectious Diseases","author":"Kontoyiannis DP","year":"2009","unstructured":"Kontoyiannis DP, Lewis RE. Agents of mucormycosis and entomophthrora-mycosis. In: , Mandell GL, Bennett JE, Dolin R, eds. Principles and Practice of Infectious Diseases. 7th ed. Philadelphia, Pennsylvania: Churchill Linvingstone\/Elsevier, 2009:3257\u20133270.","edition":"7"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/428780"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1086\/605445"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1086\/590004"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197658040-00004"},{"issue":"5","key":"e_1_3_1_16_2","first-page":"1134","article-title":"Revision total hip arthroplasty for instability: surgical techniques and principles","volume":"90","author":"Parvizi J","year":"2008","unstructured":"Parvizi J, Picinic E, Sharkey PF. Revision total hip arthroplasty for instability: surgical techniques and principles. J Bone Joint Surg Am. 2008; 90(5):1134\u20131142.","journal-title":"J Bone Joint Surg Am"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-010-1362-0"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200410000-00028"},{"issue":"3","key":"e_1_3_1_19_2","first-page":"166","article-title":"In vitro comparison between commercially and manually mixed antibiotic-loaded bone cements","volume":"8","author":"Ferraris S","year":"2010","unstructured":"Ferraris S, Miola M, Bistolfi A, et al. In vitro comparison between commercially and manually mixed antibiotic-loaded bone cements. Appl Biomater Biomech. 2010; 8(3):166\u2013174.","journal-title":"Appl Biomater Biomech"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.E.01070"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1M143"}],"container-title":["Orthopedics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.healio.com\/doiresolver?doi=10.3928\/01477447-20120919-30","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T12:44:54Z","timestamp":1683117894000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.healio.com\/doi\/10.3928\/01477447-20120919-30"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":20,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.3928\/01477447-20120919-30"],"URL":"https:\/\/doi.org\/10.3928\/01477447-20120919-30","relation":{},"ISSN":["0147-7447","1938-2367"],"issn-type":[{"value":"0147-7447","type":"print"},{"value":"1938-2367","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}