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Among aminoglycosides, commonly seen as the most appropriate antibiotics to be loaded into the bone cement, the highest elution rate was that of tobramycin. Among the glycopeptides, a class of antibiotics that should be considered to treat PJIs because of the prevalence of aminoglycoside resistance, vancomycin showed better elution than teicoplanin. Clindamycin, which can be associated with aminoglycosides to prepare ALACs and represents a useful option against the most common pathogens responsible for PJIs, showed the highest absolute and relative elutions among all the tested formulations. A noticeable elution was also detected for colistin, an antibiotic of last resort for treating multidrug-resistant bacteria. The current study demonstrates theoretical advantages in the preparation of ALAC for some antibiotics not routinely used in the clinical setting for PJIs. The use of these antibiotics based on the infecting bacteria sensitivity may represent a useful option for physicians to eradicate PJIs. In vivo testing should be considered in the future to confirm the results of this study.<\/jats:p>","DOI":"10.3928\/01477447-20141023-57","type":"journal-article","created":{"date-parts":[[2014,10,31]],"date-time":"2014-10-31T15:59:25Z","timestamp":1414771165000},"source":"Crossref","is-referenced-by-count":42,"title":["Drug Elution From High-Dose Antibiotic-Loaded Acrylic Cement: A Comparative, In Vitro Study"],"prefix":"10.3928","volume":"37","author":[{"given":"Giorgio","family":"Gasparini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"De Gori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Calonego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso Della","family":"Bora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetto","family":"Caroleo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olimpio","family":"Galasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2308","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.92B8.24333"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.D.02441"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198411000-00014"},{"key":"e_1_3_1_5_2","article-title":"Antibiotic-loaded cement in orthopedic surgery: a review","volume":"290851","author":"Bistolfi A","year":"2011","unstructured":"Bistolfi A, Massazza G, Vern\u00e9 E, et al. 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