{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T07:03:08Z","timestamp":1774681388904,"version":"3.50.1"},"reference-count":21,"publisher":"SLACK, Inc.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthopedics"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:p>\n            Deep infection following total knee arthroplasty is a catastrophic complication. Recently, antibiotic-loaded bone cement has been applied to prevent deep infection after total joint arthroplasty. However, there is still controversy about the prophylactic effect of antibiotic-loaded bone cement after primary total knee arthroplasty. This study reviewed 2293 patients who underwent primary total knee arthroplasty with 1-year follow-up at the authors\u2019 hospital between February 2003 and October 2012 (mean\u00b1SD age, 64.8\u00b110.7 years; male-to-female ratio, 1:5). All potential risk factors, including sex, age, height, weight, body mass index, diagnosis (osteoarthritis or other), diabetic status, operative time (categorized as either \u2264120 minutes or &gt;120 minutes), bilateral\/unilateral procedure, surgeon volume (categorized as either \u226530 cases\/year or &lt;30 cases\/year), and bone cement type, were collected. A total of 10 patients who had deep infection were identified during follow-up. Rates of deep infection for antibiotic-loaded bone cement and for plain cement were both 0.40%, and the difference was not significant with Fisher\u2019s exact test (\n            <jats:italic>P<\/jats:italic>\n            =1.000). Adjusted for the unevenly distributed risk factors (age, height, weight, diagnosis, bilateral\/unilateral surgery, and operative time) in both groups, the results of logistic analysis showed that antibiotic-loaded bone cement did not reduce the rate of deep infection following primary total knee arthroplasty compared with plain cement (\n            <jats:italic>P<\/jats:italic>\n            =.865; odds ratio, 0.835; 95% confidence interval, 0.105\u20136.713). The study showed that antibiotic-loaded bone cement had no effect on the prevention of deep infection after primary total knee arthroplasty. [\n            <jats:italic>Orthopedics.<\/jats:italic>\n            2015; 38(6):e462\u2013e466.]\n          <\/jats:p>","DOI":"10.3928\/01477447-20150603-52","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T12:43:31Z","timestamp":1434717811000},"source":"Crossref","is-referenced-by-count":35,"title":["Antibiotic Bone Cement Cannot Reduce Deep Infection After Primary Total Knee Arthroplasty"],"prefix":"10.3928","volume":"38","author":[{"given":"Hai","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gui-Xing","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Wei","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi-Sheng","family":"Weng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2308","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199610000-00017"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/529145"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.3928\/0147-7447-20051101-13"},{"issue":"11","key":"e_1_3_1_5_2","first-page":"511","article-title":"Depot effects of various antibiotics mixed with Palacos resins [in German]","volume":"41","author":"Buchholz HW","year":"1970","unstructured":"Buchholz HW, Engelbrecht H. 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Sensitivity to constituents of bone cement in a patient with joint prosthesis [in German]. 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