{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T01:10:27Z","timestamp":1767921027728,"version":"3.49.0"},"reference-count":30,"publisher":"SLACK, Inc.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthopedics"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:p>\n            Pseudoarthrosis, or nonunion, of the long bones is a challenging medical condition for orthopedic surgeons to treat. Therefore, healing enhancer materials are commonly used. The authors investigated whether platelet-rich fibrin accelerates long bone healing by comparing radiological and histological findings in a rat model of open femoral fracture. Platelet-rich fibrin is a current biomaterial that contains many growth factors and platelets. There are no studies in the literature investigating the effects of platelet-rich fibrin on fracture healing. Sixteen mature male rats were divided into 2 groups. In both groups, an open femoral fracture was created. The platelet-rich fibrin was obtained by centrifuging blood collected from the rats. Rats in the study group were treated with sterile platelet-rich fibrin, and those in the control group were administered saline. The rats were killed at the end of 4 weeks and examined histologically and radiologically. The radiographic and histological scores of the 2 groups differed significantly (\n            <jats:italic>P<\/jats:italic>\n            &lt;.05). These results indicate that platelet-rich fibrin is an efficient biomaterial in fracture healing and that it increases the amount of osseous tissue formation. Platelet-rich fibrin does not cause an allergic reaction, is cost-effective, and is easy to obtain. Additional studies are necessary to determine whether platelet-rich fibrin accelerates the fracture healing process or induces a better quality of fracture healing. [\n            <jats:italic>Orthopedics.<\/jats:italic>\n            2017; 40(3):e479\u2013e484.]\n          <\/jats:p>","DOI":"10.3928\/01477447-20170308-02","type":"journal-article","created":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T13:19:56Z","timestamp":1489583996000},"source":"Crossref","is-referenced-by-count":27,"title":["Evaluation of the Effect of Platelet-Rich Fibrin on Long Bone Healing: An Experimental Rat Model"],"prefix":"10.3928","volume":"40","author":[{"given":"Turan Cihan","family":"D\u00fclgeroglu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan","family":"Metineren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2308","reference":[{"key":"e_1_3_1_2_2","first-page":"68","volume-title":"Principles of Orthopaedic Practice","author":"Dee R","year":"1988","unstructured":"Dee R. Bone healing. In: , Dee R, Mango E, Hurst E, eds. 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