{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:21:12Z","timestamp":1759940472323,"version":"3.41.0"},"reference-count":4,"publisher":"SLACK, Inc.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthopedics"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:p>A 22-year-old man was referred for orthopedic follow-up after an ankle injury. Initial evaluation in urgent care included radiographs with negative findings. After a delayed presentation, a course of functional treatment was recommended. Subsequently, he developed a deep venous thrombosis and pulmonary emboli. He was found to be factor V Leiden deficient and was fully anticoagulated on warfarin. Later reevaluation revealed a steppage gait and foot drop. Electrodiagnostic studies (ie, electromyography and nerve conduction studies) revealed a severe peripheral polyneuropathy. The patient admitted to engaging in high-volume recreational use of nitrous oxide. Neurological evaluation confirmed vitamin B12 deficiency consistent with the toxic effects of nitrous oxide. The patient's condition improved with vitamin B supplementation, bracing, and avoidance of nitrous oxide and similar neurotoxins. He participated in a 3-month physical rehabilitation program, and he displayed partial recovery at most recent follow-up. [<jats:italic>Orthopedics.<\/jats:italic>2018; 41(3):e432\u2013e433.]<\/jats:p>","DOI":"10.3928\/01477447-20171102-05","type":"journal-article","created":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T13:27:48Z","timestamp":1510234068000},"source":"Crossref","is-referenced-by-count":3,"title":["Peripheral Neuropathy Due to Recreational Use of Nitrous Oxide Presenting After an Ankle Sprain With Foot Drop"],"prefix":"10.3928","volume":"41","author":[{"given":"Jackson A.","family":"Middleton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Roffers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2308","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.28.5.485"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2014-001071"},{"key":"e_1_3_1_4_2","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2016-215728","article-title":"Nitrous oxide misuse and vitamin B12 deficiency","volume":"2016","author":"Massey TH","year":"2016","unstructured":"Massey TH, Pickersgill TT, Peall KJ. Nitrous oxide misuse and vitamin B12 deficiency. BMJ Case Rep. 2016; 2016:bcr2016215728.","journal-title":"BMJ Case Rep"},{"issue":"5","key":"e_1_3_1_5_2","first-page":"894","article-title":"Myelopathy caused by nitrous oxide toxicity","volume":"19","author":"Pema PJ","year":"1998","unstructured":"Pema PJ, Horak HA, Wyatt RH. Myelopathy caused by nitrous oxide toxicity. AJNR Am J Neuroradiol. 1998; 19(5):894\u2013896.","journal-title":"AJNR Am J Neuroradiol"}],"container-title":["Orthopedics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.healio.com\/doiresolver?doi=10.3928\/01477447-20171102-05","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T23:16:35Z","timestamp":1750979795000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.healio.com\/doi\/10.3928\/01477447-20171102-05"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":4,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.3928\/01477447-20171102-05"],"URL":"https:\/\/doi.org\/10.3928\/01477447-20171102-05","relation":{},"ISSN":["0147-7447","1938-2367"],"issn-type":[{"type":"print","value":"0147-7447"},{"type":"electronic","value":"1938-2367"}],"subject":[],"published":{"date-parts":[[2018,5]]}}}