{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T21:46:15Z","timestamp":1773611175673,"version":"3.50.1"},"reference-count":70,"publisher":"SLACK, Inc.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthopedics"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>\n            Individuals with osteoarthritis have a diminished quality of life, and the condition is a major cause of disability. Newer biologic treatments have been developed that are believed to modify disease progression. These predominantly include hyaluronic acid, platelet-rich plasma, bone marrow aspirate concentrate, and adipose-derived mesenchymal stem cells. There is conflicting evidence regarding the use of orthobiologics for osteoarthritis and for focal chondral defects, although most studies indicate that injections of biologics are safe and without significant adverse effects. [\n            <jats:italic>Orthopedics<\/jats:italic>\n            . 2019; 42(2):66\u201373.]\n          <\/jats:p>","DOI":"10.3928\/01477447-20190225-02","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T18:15:39Z","timestamp":1553019339000},"page":"66-73","source":"Crossref","is-referenced-by-count":19,"title":["The Role of Orthobiologics in the Management of Osteoarthritis and Focal Cartilage Defects"],"prefix":"10.3928","volume":"42","author":[{"given":"Benjamin J.","family":"Sherman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Chahla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Glowney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel M.","family":"Frank","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2308","reference":[{"key":"e_1_3_1_2_2","unstructured":"Centers for Disease Control and Prevention. Osteoarthritis (OA). http:\/\/www.cdc.gov\/arthritis\/basics\/osteoarthritis.htm. Accessed October 9 2018."},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20430"},{"issue":"1","key":"e_1_3_1_4_2","first-page":"4","article-title":"National and state medical expenditures and lost earnings attributable to arthritis and other rheumatic conditions\u2014United States, 2003","volume":"56","author":"Centers for Disease Control and Prevention","year":"2007","unstructured":"Centers for Disease Control and Prevention. National and state medical expenditures and lost earnings attributable to arthritis and other rheumatic conditions\u2014United States, 2003. MMWR Morb Mortal Wkly Rep. 2007;56(1):4\u20137.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-011-1713-8"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-200009000-00001"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1063-4584(97)80019-2"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-015-0775-z"},{"key":"e_1_3_1_9_2","volume-title":"Euflexxa [package insert]","year":"2016","unstructured":"Euflexxa [package insert]. Parsippany, NJ: Ferring Pharmaceuticals Inc; 2016."},{"key":"e_1_3_1_10_2","volume-title":"Synvisc [package insert]","year":"2014","unstructured":"Synvisc [package insert]. Ridgefield, NJ: Genzyme Corp; 2014."},{"key":"e_1_3_1_11_2","volume-title":"Synvisc-One [package insert]","year":"2014","unstructured":"Synvisc-One [package insert]. Ridgefield, NJ: Genzyme Corp; 2014."},{"key":"e_1_3_1_12_2","volume-title":"Supartz [package insert]","year":"2015","unstructured":"Supartz [package insert]. Durham, NC: Bioventus LLC; 2015."},{"key":"e_1_3_1_13_2","volume-title":"Durolane [package insert]","year":"2015","unstructured":"Durolane [package insert]. Durham, NC: Bioventus LLC; 2015."},{"key":"e_1_3_1_14_2","volume-title":"Hyalgan [package insert]","year":"2014","unstructured":"Hyalgan [package insert]. Parsippany, NJ: Fidia Pharma USA Inc; 2014."},{"key":"e_1_3_1_15_2","volume-title":"Orthovisc [package insert]","year":"2005","unstructured":"Orthovisc [package insert]. Woburn, MA: Anika Therapeutics; 2005."},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026078"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/147323000603400110"},{"issue":"1","key":"e_1_3_1_18_2","first-page":"26","article-title":"Comparison of two different molecular weight intra-articular injections of hyaluronic acid for the treatment of knee osteoarthritis","volume":"20","author":"Gigis I","year":"2016","unstructured":"Gigis I, Fotiadis E, Nenopoulos A, Tsitas K, Hatzokos I. Comparison of two different molecular weight intra-articular injections of hyaluronic acid for the treatment of knee osteoarthritis. Hippokratia. 2016;20(1):26\u201331.","journal-title":"Hippokratia"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2018.01.009"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-201310160-00010"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOS-D-17-00164"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2015.03.030"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/1947603510366718"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546508328415"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/1071100715578435"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546516656179"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-016-3984-6"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eats.2016.10.023"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000138251.07040.51"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2804"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2005.10.011"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546511419278"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546510387517"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1186\/scrt218"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-016-3981-9"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-015-0172-4"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.L.00019"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546515580787"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546516665809"},{"key":"e_1_3_1_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2016.09.024"},{"key":"e_1_3_1_41_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546511417792"},{"key":"e_1_3_1_42_2","doi-asserted-by":"publisher","DOI":"10.1589\/jpts.29.896"},{"key":"e_1_3_1_43_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546515624678"},{"issue":"7","key":"e_1_3_1_44_2","first-page":"901","article-title":"Effect of single injection of platelet-rich plasma in comparison with corticosteroid on knee osteoarthritis: a double-blind randomized clinical trial","volume":"56","author":"Forogh B","year":"2016","unstructured":"Forogh B, Mianehsaz E, Shoaee S, Ahadi T, Raissi GR, Sajadi S. Effect of single injection of platelet-rich plasma in comparison with corticosteroid on knee osteoarthritis: a double-blind randomized clinical trial. J Sports Med Phys Fitness. 2016;56(7\u20138):901\u2013908.","journal-title":"J Sports Med Phys Fitness"},{"key":"e_1_3_1_45_2","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.141150"},{"key":"e_1_3_1_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00590-012-1038-4"},{"issue":"4","key":"e_1_3_1_47_2","first-page":"41","article-title":"Intraoperative application platelet rich fibrin, postoperative injections of PRP or microfracture only for osteochondral lesions of the knee: a five-year retrospective evaluation","volume":"30","author":"Papalia R","year":"2016","unstructured":"Papalia R, Diaz Balzani L, Torre G, et al. Intraoperative application platelet rich fibrin, postoperative injections of PRP or microfracture only for osteochondral lesions of the knee: a five-year retrospective evaluation. J Biol Regul Homeost Agents. 2016;30(4)(suppl 1):41\u201349.","journal-title":"J Biol Regul Homeost Agents"},{"key":"e_1_3_1_48_2","doi-asserted-by":"publisher","DOI":"10.1177\/1071100718779390"},{"key":"e_1_3_1_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1251"},{"key":"e_1_3_1_50_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V78.1.55.55"},{"key":"e_1_3_1_51_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.L.01529"},{"key":"e_1_3_1_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2012.08.021"},{"key":"e_1_3_1_53_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2016.2489"},{"key":"e_1_3_1_54_2","volume-title":"Angel cPRP & Bone Marrow Processing System [package insert]","year":"2018","unstructured":"Angel cPRP & Bone Marrow Processing System [package insert]. Naples, FL: Arthrex; 2018."},{"key":"e_1_3_1_55_2","volume-title":"BioCUE Platelet Concentration System [package insert]","year":"2011","unstructured":"BioCUE Platelet Concentration System [package insert]. Warsaw, IN: Biomet Orthopedics; 2011."},{"key":"e_1_3_1_56_2","volume-title":"Magellan Autologous Platelet Separator System including associated disposables [operator's manual]","year":"2018","unstructured":"Magellan Autologous Platelet Separator System including associated disposables [operator's manual]. Hopkinton, MA: Arteriocyte Medical Systems, Inc; 2018."},{"key":"e_1_3_1_57_2","volume-title":"ART BMC [package insert]","year":"2014","unstructured":"ART BMC [package insert]. Austin, TX: Celling Biosciences; 2014."},{"key":"e_1_3_1_58_2","volume-title":"Biologics Preparation Technique [product manual]","year":"2012","unstructured":"Biologics Preparation Technique [product manual]. Gainesville, FL: Exactech Biologics; 2012."},{"key":"e_1_3_1_59_2","doi-asserted-by":"publisher","DOI":"10.1177\/1947603518768080"},{"key":"e_1_3_1_60_2","doi-asserted-by":"publisher","DOI":"10.1177\/2325967115625481"},{"key":"e_1_3_1_61_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00590-013-1393-9"},{"key":"e_1_3_1_62_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546516662455"},{"key":"e_1_3_1_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2015.07.012"},{"key":"e_1_3_1_64_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/597652"},{"key":"e_1_3_1_65_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e02-02-0105"},{"key":"e_1_3_1_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eats.2017.06.048"},{"key":"e_1_3_1_67_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546517719454"},{"key":"e_1_3_1_68_2","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2015-0245"},{"key":"e_1_3_1_69_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40634-018-0169-x"},{"key":"e_1_3_1_70_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-018-4955-x"},{"key":"e_1_3_1_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2015.09.010"}],"container-title":["Orthopedics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.healio.com\/doiresolver?doi=10.3928\/01477447-20190225-02","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T05:28:47Z","timestamp":1683091727000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.healio.com\/doi\/10.3928\/01477447-20190225-02"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":70,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.3928\/01477447-20190225-02"],"URL":"https:\/\/doi.org\/10.3928\/01477447-20190225-02","relation":{},"ISSN":["0147-7447","1938-2367"],"issn-type":[{"value":"0147-7447","type":"print"},{"value":"1938-2367","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3]]}}}