{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:11:55Z","timestamp":1790413915675,"version":"4.1.0"},"reference-count":32,"publisher":"SLACK, Inc.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthopedics"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:p>\n            This study examined the correlation between preoperative transcutaneous oxygen perfusion (TcPO\n            <jats:sub>2<\/jats:sub>\n            ) measurement and the success of wound healing after major lower extremity amputation. There is no validated consensus on how to accurately determine appropriate amputation levels. A TcPO\n            <jats:sub>2<\/jats:sub>\n            greater than 30 to 40 mm Hg is widely cited as a positive predictor of postoperative wound healing, but its validity has not been well defined. A retrospective chart review was performed for patients who underwent above-knee amputation (AKA), through-knee amputation, or below-knee amputation (BKA) at a single institution from 2012 to 2018 with preoperative TcPO\n            <jats:sub>2<\/jats:sub>\n            values and a minimum 30-day postoperative clinical follow-up. This review yielded 141 total amputations: 93 BKAs, 6 through-knee amputations, and 42 AKAs. Fifty-five amputations were unsuccessful, defined by postoperative wound dehiscence or infection. Of these, 37 were BKAs, 4 were through-knee amputations, and 14 were AKAs. There was a significant difference in preoperative TcPO\n            <jats:sub>2<\/jats:sub>\n            between the successful and unsuccessful amputations, at 46.2 and 38.3 mm Hg, respectively (\n            <jats:italic>P<\/jats:italic>\n            =.02). A TcPO\n            <jats:sub>2<\/jats:sub>\n            of 30 to 40 mm Hg showed a 68.8% success rate, and a TcPO\n            <jats:sub>2<\/jats:sub>\n            of less than 20 mm Hg showed an 18.2% success rate. A receiver operating characteristic curve for TcPO\n            <jats:sub>2<\/jats:sub>\n            predicting amputation success had an area under the curve of 0.53 for AKAs and 0.61 for BKAs; the diagnostic ability is far from prognostic. There is no linear association between TcPO\n            <jats:sub>2<\/jats:sub>\n            and success rate. A TcPO\n            <jats:sub>2<\/jats:sub>\n            of less than 20 mm Hg has a high positive predictive value for failure, but higher levels are not 100% predictive of wound healing success after amputation, as previously reported. [\n            <jats:italic>Orthopedics<\/jats:italic>\n            . 2022;45(3):174\u2013180.]\n          <\/jats:p>","DOI":"10.3928\/01477447-20220128-05","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T15:14:16Z","timestamp":1643901256000},"page":"174-180","source":"Crossref","is-referenced-by-count":4,"title":["Preoperative Transcutaneous Oxygen Perfusion Measurements in Predicting Atraumatic Wound Healing After Major Lower Extremity Amputation"],"prefix":"10.3928","volume":"45","author":[{"given":"Naudereh","family":"Noori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Haruno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Schroeder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Vrahas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milton","family":"Little","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2308","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2007.11.005"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1978.tb01397.x"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs0600499"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(02)04952-3"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198408000-00007"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0741-5214(84)90069-7"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20140571"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-010-9968-x"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0b013e3182876a06"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2010.19.5.48048"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198264030-00007"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2006.12.027"},{"key":"e_1_3_1_14_2","first-page":"31","article-title":"Predicting stump healing following amputation for peripheral vascular disease using the transcutaneous oxygen monitor","volume":"68","author":"Dowd GS","year":"1986","unstructured":"Dowd GS. 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