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A negative work-up for malignancy prompted infectious work-up and biopsies, revealing positive methicillin-sensitive\n            <jats:italic>Staphylococcus aureus<\/jats:italic>\n            cultures, yet a curious finding of perivascular lymphocytic infiltrates and fibrinoid necrosis from both the dermal vessel wall from a skin biopsy and humeral head bone biopsy, suggestive of pyoderma gangrenosum. This was a previously undocumented presentation of pyoderma gangrenosum invasion into a large joint with concomitant bacterial septic arthritis. 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