{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T21:15:51Z","timestamp":1786828551843,"version":"build-2736575974"},"reference-count":24,"publisher":"SLACK, Inc.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthopedics"],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:p>Primary bone tumors are rare yet present a significant burden to patients, with surgery being the mainstay of treatment. We reviewed outcomes of limb salvage (LS) and amputation for management of upper extremity tumors. We followed Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines for systematic reviews. A total of 2,886 studies were screened, and 5 studies were included (n = 187 patients; LS = 101, Amputation = 86). Commonly reported outcomes included local recurrence, metastasis at follow-up, and survival. Metastasis and local recurrence rates were in favor of LS surgery, with some studies reporting no differences. Survival was consistently reported to be statistically significantly in favor of LS.<\/jats:p>","DOI":"10.3928\/01477447-20260422-01","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T12:47:42Z","timestamp":1779972462000},"source":"Crossref","is-referenced-by-count":1,"title":["Limb Salvage Versus Amputation for the Management of Primary Bone Tumors of the Upper Extremity: A Systematic Review"],"prefix":"10.3928","volume":"49","author":[{"given":"Anas El","family":"Zouhbi","sequence":"first","affiliation":[{"name":"From Division of Orthopedic Surgery, Department of Surgery, American University of Beirut Medical Center and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Wanna","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, American University of Beirut, Beirut, Lebanon."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jad M.","family":"El Abiad","sequence":"additional","affiliation":[{"name":"From Division of Orthopedic Surgery, Department of Surgery, American University of Beirut Medical Center and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Fatfat","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, American University of Beirut, Beirut, Lebanon."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Yassine","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, American University of Beirut, Beirut, Lebanon."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachid","family":"Haidar","sequence":"additional","affiliation":[{"name":"From Division of Orthopedic Surgery, Department of Surgery, American University of Beirut Medical Center and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2308","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-025-13720-0"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12938-021-00860-0"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930510113"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.09.006"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-014-2086-5"},{"key":"e_1_3_2_7_2","first-page":"421","volume-title":"Pediatric and Adolescent Osteosarcoma","author":"Ottaviani G","year":"2010","unstructured":"Ottaviani G, Robert RS, Huh WW, Jaffe N. Functional, psychosocial and professional outcomes in long-term survivors of lower-extremity osteosarcomas: amputation versus limb salvage. In: Jaffe N, Bruland OS, Bielack S, eds. Pediatric and Adolescent Osteosarcoma; vol 152. Springer US; 2010:421\u2013436."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000195413.16150.bc"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453679708996180"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2014.11.038"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21114"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.25838"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2354.2007.00854.x"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-016-0500-0"},{"issue":"2","key":"e_1_3_2_16_2","first-page":"e21","article-title":"A meta-analysis of limb-salvage versus amputation in the treatment of patients with Enneking\u2021U pathologic fracture osteosarcoma","volume":"51","author":"Jiang F","year":"2015","unstructured":"Jiang F, Shi Y, Li GJ, Zhou F. A meta-analysis of limb-salvage versus amputation in the treatment of patients with Enneking\u2021U pathologic fracture osteosarcoma. Indian J Cancer. 2015;51(suppl 2):e21\u2013e24. 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