{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:26:56Z","timestamp":1787066816518,"version":"build-2736575974"},"reference-count":37,"publisher":"SLACK, Inc.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthopedics"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Periprosthetic joint infection (PJI) is one of the most serious complications following total knee arthroplasty (TKA). Vancomycin powder has been proposed as a low-cost adjunct to reduce infection by providing high local antibiotic concentrations with minimal systemic exposure; however, clinical evidence remains inconsistent. This study aimed to evaluate the effect of intra-articular vancomycin powder on PJI, aseptic wound complications, and renal function in primary TKA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Patients who underwent primary TKA between 2022 and 2024 with at least 1 year of follow-up were retrospectively analyzed. A total of 661 patients were included: 247 received 1 g intra-articular vancomycin powder and 414 served as controls. All procedures were performed with standardized perioperative protocols. Demographics, comorbidities, and high-risk status were recorded. Outcomes included PJI, aseptic wound complications, and acute kidney injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      PJI occurred in 7 patients (1.1%): 6 in the control group (1.4%) and 1 in the vancomycin group (0.4%), with no significant difference (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .266). Aseptic wound complications were observed in 28 patients (4.2%), including 20 control patients (4.8%) and 8 vancomycin patients (3.2%) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .326). Acute kidney injury occurred in 12 patients (1.8%), with comparable rates between groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 1.000).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Intra-articular vancomycin powder did not result in a statistically significant reduction in PJI rates, while demonstrating a favorable safety profile. Although safe, routine use may not provide additional measurable benefit in optimized surgical settings with low baseline infection rates. Larger, well-designed randomized trials are required to identify patient subgroups who may benefit from selective application.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3928\/01477447-20260615-01","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:54:52Z","timestamp":1782399292000},"source":"Crossref","is-referenced-by-count":0,"title":["Intra-Articular Vancomycin Powder in Primary Total Knee Arthroplasty: A Retrospective Observational Study"],"prefix":"10.3928","volume":"49","author":[{"given":"Kemal","family":"\u015eibar","sequence":"first","affiliation":[{"name":"Sultan 2. Abd\u00fclhamid Han Training and Research Hospital, Department of Orthopedics and Traumatology, \u0130stanbul, Etlik City Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vedat","family":"Bi\u00e7ici","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Ankara, Haydarpa\u015fa Numune Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezgi Gizem","family":"\u015eibar","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, \u0130stanbul, Republic of T\u00fcrkiye Ministry of Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasin","family":"Erdo\u011fan","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Ankara, Haydarpa\u015fa Numune Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erkan","family":"Akg\u00fcn","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Ankara, Haydarpa\u015fa Numune Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanife","family":"Uzar","sequence":"additional","affiliation":[{"name":"Gaziantep Provincial Health Administration, Gaziantep"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Firat","sequence":"additional","affiliation":[{"name":"\u0130stinye University, VM Medical Park Hospital, Department of Orthopedics and Traumatology, Ankara, T\u00fcrkiye."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2308","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-009-1013-5"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2007.10.017"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2018.05.042"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-017-5396-4"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11040486"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otsr.2020.01.007"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jor.2024.03.040"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61798-0"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.90B7.20498"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","unstructured":"Hanssen AD Osmon DR Patel R. 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